Age-related phospholipid hydroperoxide levels in gerbil brain measured by HPLC-chemiluminescence and their relation to hydroxyl radical stress

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Free radical theory of aging

1992 • 876 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Lipid hydroperoxide measurement by oxidation of Fe²⁺ in the presence of xylenol orange. Comparison with the TBA assay and an iodometric method

1991 • 607 citations

Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke?

1989 • 471 citations

Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.

1990 • 461 citations

A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

1987 • 428 citations

An introduction to the free radical hypothesis in Parkinson's disease

1992 • 385 citations

Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography

1987 • 362 citations

Endogenous DNA damage as related to cancer and aging

1989 • 323 citations

Oxygen free radicals and Parkinson's disease

1991 • 293 citations

Hydroxylation of salicylate as an assay for hydroxyl radicals: A cautionary note

1991 • 271 citations

Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats.

1989 • 237 citations

Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay

1989 • 234 citations

Noninvasive measures of oxidative stress status in humans

1991 • 230 citations

Monoamine oxidase, hydrogen peroxide, and Parkinson's disease.

1987 • 173 citations

Use of salicylate with high pressure liquid chromatography and electrochemical detection (LCE) as a sensitive measure of hydroxyl free radicals in adriamycin treated rats

1986 • 164 citations

Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains

1986 • 163 citations

Salicylate hydroxylation as an early marker of in vivo oxidative stress in diabetic patients

1992 • 139 citations

Chemiluminescence - High Performance Liquid Chromatography of Phosphatidylcholine Hydroperoxide

1987 • 138 citations

Hydroxyl radical production and lipid peroxidation paralles selective post‐ischemic vulnerability in gerbil brain

1993 • 133 citations

Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases

1989 • 131 citations

Age‐Related Regional Changes in Hydroxyl Radical Stress and Antioxidants in Gerbil Brain

1993 • 93 citations

Consecutive action of phospholipase A2 and glutathione peroxidase is required for reduction of phospholipid hydroperoxides and provides a convenient method to determine peroxide values in membranes

1985 • 87 citations

A colorimetric microdetermination of peroxide values utilizing aluminum chloride as the catalyst

1980 • 86 citations

Age influence on oxidative events during brain ischemia/reperfusion

1991 • 81 citations

Phospholipid Hydroperoxide Accumulation in Liver of Rats Intoxicated with Carbon Tetrachloride and Its Inhibition by Dietary α-Tocopherol

1990 • 75 citations

Quantitative analysis of effects of kappa-opioid agonists on postischemic hippocampal CA1 neuronal necrosis in gerbils.

1988 • 66 citations

Age-related vulnerability to cerebral ischemia in spontaneously hypertensive rats.

1991 • 62 citations

Comparison of plasma levels of lipid hydroperoxides and antioxidants in hyperlipidemic nagase analbuminemic rats, sprague-dawley rats, and humans

1992 • 34 citations

Iron-Melanin Interaction and Parkinson's Disease

1993 • 12 citations

The Genotoxic Effects of Arachidonic Acid in V79 Cells Are Mediated by Peroxidation Products

1993 • 9 citations