Mutagenesis of residues flanking Lys-40 enhances the enzymic activity and reduces the angiogenic potency of angiogenin

Rapid analysis of amino acids using pre-column derivatization

1984 • 2,491 citations

Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells

1985 • 911 citations

Amino acid sequence of human tumor derived angiogenin

1985 • 357 citations

Characteristic ribonucleolytic activity of human angiogenin

1986 • 354 citations

Cloning and sequencing of the intronless gene for angiogenin, a human angiogenesis factor

1985 • 273 citations

Avascular and vascular phases of tumour growth in the chick embryo

1977 • 225 citations

Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis

1989 • 191 citations

Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin.

1987 • 189 citations

Active site dynamics of ribonuclease.

1985 • 164 citations

Tight-binding inhibition of angiogenin and ribonuclease A by placental ribonuclease inhibitor

1989 • 163 citations

THE MECHANISM OF ACTION OF RIBONUCLEASE

1969 • 137 citations

Specific binding of angiogenin to calf pulmonary artery endothelial cells.

1989 • 134 citations

Role of lysines in human angiogenin: chemical modification and site-directed mutagenesis

1989 • 123 citations

The structure of cytidilyl(2′,5′)adenosine when bound to pancreatic ribonuclease S

1977 • 122 citations

Expression of Met-(−1) angiogenin in Escherichia coli: Conversion to the authentic <Glu-1 protein

1988 • 105 citations

A covalent angiogenin/ribonuclease hybrid with a fourth disulfide bond generated by regional mutagenesis

1989 • 103 citations

Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2.

1989 • 95 citations

Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity

1986 • 91 citations

Angiogenin activates endothelial cell phospholipase C.

1988 • 88 citations

Ribonucleolytic activity of angiogenin: essential histidine, lysine, and arginine residues.

1987 • 87 citations

Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of ribosomes.

1987 • 85 citations

A preliminary three-dimensional structure of angiogenin.

1986 • 67 citations

Angiogenin abolishes cell-free protein synthesis by specific ribonucleolytic inactivation of 40S ribosomes

1988 • 42 citations

Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin.

1988 • 40 citations

Amino acid sequence of bovine angiogenin

1989 • 36 citations

Angiogenin activates phospholipase C and elicits a rapid incorporation of fatty acid into cholesterol esters in vascular smooth muscle cells

1990 • 35 citations

Modulation of mitogenic stimuli by angiogenin correlates with in vitro phosphatidylinositol bisphosphate synthesis.

1989 • 31 citations

Pentacoordinated molecules. 28. Computer simulation of ribonuclease action on uridylyl-(3'-5')-adenosine

1978 • 26 citations

Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis

1990 • 20 citations