Protocolized Intensive Care Unit Management of Analgesia, Sedation, and Delirium Improves Analgesia and Subsyndromal Delirium Rates

Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs

2000 • 3,409 citations

The Richmond Agitation–Sedation Scale

2002 • 3,106 citations

Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit

2004 • 2,847 citations

Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation

2000 • 2,838 citations

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial

2008 • 1,894 citations

Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult

2002 • 1,858 citations

Monitoring Sedation Status Over Time in ICU Patients

2003 • 1,514 citations

Intensive Care Delirium Screening Checklist: evaluation of a new screening tool

2001 • 1,319 citations

Lorazepam Is an Independent Risk Factor for Transitioning to Delirium in Intensive Care Unit Patients

2005 • 1,161 citations

Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation

1999 • 999 citations

Incidence, risk factors and consequences of ICU delirium

2006 • 958 citations

Assessing pain in critically ill sedated patients by using a behavioral pain scale

2001 • 956 citations

The Long-term Psychological Effects of Daily Sedative Interruption on Critically Ill Patients

2003 • 641 citations

Impact of systematic evaluation of pain and agitation in an intensive care unit*

2006 • 494 citations

Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients*

2004 • 398 citations

Subsyndromal delirium in the ICU: evidence for a disease spectrum

2007 • 303 citations

Patients with Alcohol Problems

1998 • 275 citations

Validation of a Behavioral Pain Scale in Critically Ill, Sedated, and Mechanically Ventilated Patients

2005 • 254 citations

Sedation algorithm in critically ill patients without acute brain injury

2005 • 245 citations

Relationship between behavioral and physiological indicators of pain, critical care patients' self-reports of pain, and opioid administration

1997 • 233 citations

Quality improvement report: Effect of a scoring system and protocol for sedation on duration of patients' need for ventilator support in a surgical intensive care unit

2002 • 214 citations

A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit*

2008 • 186 citations

An Analgesia–Delirium–Sedation Protocol for Critically Ill Trauma Patients Reduces Ventilator Days and Hospital Length of Stay

2008 • 168 citations

Improved recovery after music and therapeutic suggestions during general anaesthesia: a double‐blind randomised controlled trial

2001 • 159 citations

Combined didactic and scenario-based education improves the ability of intensive care unit staff to recognize delirium at the bedside

2008 • 155 citations

Feeling Safe: The Psychosocial Needs of ICU Patients

2000 • 150 citations

Drug combinations in pain treatment: a review of the published evidence and a method for finding the optimal combination

2002 • 92 citations

Examination and learning: an activity‐theoretical analysis of the relationship between assessment and educational practice

2004 • 82 citations

Music therapy: a nursing intervention for the control of pain and anxiety in the ICU: a review of the research literature.

1995 • 80 citations

The need to know: experiences of critically ill patients

2000 • 71 citations

Music Therapy for Assistance with Pain and Anxiety Management in Burn Treatment

2001 • 71 citations

Music Therapy

1995 • 57 citations