The pathogenesis of pulmonary edema

On the Absorption of Fluids from the Connective Tissue Spaces

1896 • 2,075 citations

STUDIES ON INFLAMMATION

1961 • 1,539 citations

THE ULTRASTRUCTURAL BASIS OF CAPILLARY PERMEABILITY STUDIED WITH PEROXIDASE AS A TRACER

1967 • 1,495 citations

Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients

1968 • 1,237 citations

Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis

1977 • 1,014 citations

Passage of Molecules Through Capillary Walls

1953 • 942 citations

TRANSPORT OF AIR ALONG SHEATHS OF PULMONIC BLOOD VESSELS FROM ALVEOLI TO MEDIASTINUM

1939 • 743 citations

THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES

1971 • 658 citations

Pulmonary edema.

1974 • 642 citations

Lymphatics, lymph and the lymphomyeloid complex,

1970 • 578 citations

Effect of Elevated Left Atrial Pressure and Decreased Plasma Protein Concentration on the Development of Pulmonary Edema

1959 • 555 citations

Alterations of the Gas Exchange Apparatus in Adult Respiratory Insufficiency Associated with Septicemia^1,2

1977 • 551 citations

Permeability of muscle capillaries to small heme-peptides. Evidence for the existence of patent transendothelial channels.

1975 • 540 citations

Pulmonary edema in dogs, especially the sequence of fluid accumulation in lungs.

1967 • 503 citations

The Cells of the Pulmonary Airways^1,2

1977 • 460 citations

STUDIES ON BLOOD CAPILLARIES

1968 • 449 citations

Increased Sheep Lung Vascular Permeability Caused by Pseudomonas Bacteremia

1974 • 434 citations

Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies.

1969 • 420 citations

Lung surfactant

1974 • 407 citations

DEVELOPMENT OF FINE STRUCTURAL DAMAGE TO ALVEOLAR AND CAPILLARY LINING CELLS IN OXYGEN-POISONED RAT LUNGS

1967 • 393 citations

Increased sheep lung vascular permeability caused by Escherichia coli endotoxin.

1979 • 362 citations

Bioengineering Aspects of the Lung.

1978 • 351 citations

Effect of increased vascular pressure on lung fluid balance in unanesthetized sheep.

1975 • 348 citations

Multiple pathways of capillary permeability.

1977 • 313 citations

Pulmonary capillary pressure and filtration coefficient in the isolated perfused lung

1967 • 305 citations

Surface Lining of Lung Alveoli

1965 • 294 citations

Interstitial Fluid Pressure: II. Pressure-Volume Curves of Interstitial Space

1965 • 289 citations

The value of edema fluid protein measurement in patients with pulmonary edema

1979 • 282 citations

Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes

1970 • 278 citations

THE PULMONARY ALVEOLAR MUCOID FILM AND THE PNEUMONOCYTES

1954 • 277 citations

LASERS IN THE LABORATORY

1964 • 269 citations

Direct determination of surface tension in the lung.

1976 • 232 citations

THE ULTRASTRUCTURAL BASIS OF ALVEOLAR-CAPILLARY MEMBRANE PERMEABILITY TO PEROXIDASE USED AS A TRACER

1968 • 227 citations

Penetration of the respiratory epithelium of guinea pigs following exposure to cigarette smoke.

1974 • 215 citations

Differential permeability of endothelial and epithelial barriers to albumin flux

1979 • 193 citations

Physiologic, biochemical, immunologic and pathologic changes following ozone exposure

1959 • 178 citations

Neurohemodynamics of Pulmonary Edema

1952 • 174 citations

Pulmonary edema due to increased microvascular permeability to fluid and protein.

1978 • 165 citations

The microembolism syndrome

1972 • 165 citations

Cell Renewal in the Lungs of Rats Exposed to Low Levels of NO₂

1972 • 158 citations

Trends in microvascular research

1976 • 152 citations

Histamine and interstitial Pulmonary Edema in the Dog

1971 • 144 citations

The physiology and pharmacology of lung edema.

1956 • 143 citations

The Application of Starling's Law of Capillary Exchange to the Lungs*

1967 • 140 citations

Increased sheep lung vascular permeability caused by histamine.

1975 • 139 citations

Pulmonary edema related to changes in colloid osmotic and pulmonary artery wedge pressure in patients after acute myocardial infarction.

1975 • 136 citations

Direct Measurement of Microvascular Pressures in the Isolated Perfused Dog Lung

1980 • 136 citations

Electron Microscopic Alterations at the Alveolar Level in Pulmonary Edema

1967 • 135 citations

Lung Water and Solute Exchange.

1979 • 135 citations

Estimation of the filtration coefficient of pulmonary exchange vessels

1978 • 134 citations

High Altitude Pulmonary Edema

1978 • 132 citations

Hemoglobin as a Tracer in Hemodynamic Pulmonary Edema

1969 • 131 citations

Complement fragments, alveolar macrophages, and alveolitis.

1979 • 129 citations

Pulmonary Edema

1973 • 128 citations

Capillary Permeability to Macromolecules: Stretched Pore Phenomenon

1957 • 127 citations

Substructure of intercellular junctions in freeze-fractured alveolar-capillary membranes of mouse lung.

1976 • 122 citations

Lung fluid exchange after uneven pulmonary artery obstruction in sheep.

1978 • 121 citations

Prostaglandins and the lung.

1978 • 119 citations

Transcapillary passage of albumin, effects of tissue cooling and of increases in filtration and plasma colloid osmotic pressure

1979 • 116 citations

Pulmonary Edema and Permeability of Alveolar Membranes

1961 • 116 citations

Heroin Pulmonary Edema

1972 • 115 citations

Pathogenesis of Neurogenic Pulmonary Edema¹

1978 • 113 citations

The interaction between intracapillary and tissue forces in the overall regulation of interstitial fluid volume.

1973 • 112 citations

Pulmonary Edema

1978 • 109 citations

Pulmonary Edema

1972 • 109 citations

Pulmonary endothelial cells.

1977 • 106 citations

Lung inflation and alveolar permeability to non‐electrolytes in the adult sheep in vivo.

1976 • 105 citations

Treatment or prevention of pulmonary cellular damage with pharmacologic doses of corticosteroid.

1972 • 104 citations

THE FLOW OF LYMPH FROM THE LUNGS OF THE DOG

1942 • 101 citations

Experimental hypoxic pulmonary edema in the rat

1968 • 100 citations

The pulmonary ultrastructure in septic shock

1970 • 98 citations

Noninvasive measurement of pulmonary transvascular protein flux in sheep

1978 • 97 citations

Longitudinal distribution of vascular resistance in the pulmonary arteries, capillaries, and veins

1968 • 96 citations

Lung lymph and free interstitial fluid protein composition in sheep with edema

1976 • 94 citations

Permeability of muscle capillaries to microperoxidase.

1978 • 92 citations

Effects of alveolar hypoxia on lung fluid and protein transport in unanesthetized sheep.

1977 • 90 citations

The Adult Respiratory Distress Syndrome

1976 • 88 citations

The extracellular portion of the human blood‐air barrier and its relation to tissue space

1961 • 88 citations

Extra‐Alveolar Vessels and Edema Development in Excised Dog Lungs

1971 • 86 citations

Pulmonary vasodilator activity of prostacyclin (PGI2) in the cat.

1979 • 86 citations

Prostaglandin production associated with the pulmonary vascular response to complement activation.

1980 • 85 citations

Interstitial Fluid Pressure

1968 • 84 citations

THE FLOW OF LYMPH FROM THE LUNGS OF THE DOG

1942 • 83 citations

Relationship between colloid osmotic pressure and pulmonary artery wedge pressure in patients with acute cardiorespiratory failure

1978 • 83 citations

Centrogenic pulmonary pathology in mechanical head injury

1969 • 81 citations

Capillary Permeability

1968 • 79 citations

Mechanism of the sustained action of histamine and bradykinin on transport of large molecules across capillary walls in the dog paw

1974 • 79 citations

Mechanism of neurogenic pulmonary edema∗

1967 • 79 citations

Mechanism of pulmonary edema induced by microembolization in dogs.

1978 • 76 citations

Mechanism of the serotonin effect on lung transvascular fluid and protein movement in awake sheep.

1975 • 73 citations

PATHOLOGY OF HIGH ALTITUDE PULMONARY EDEMA

1963 • 70 citations

CEREBRAL ETIOLOGY OF THE “SHOCK LUNG SYNDROME”

1972 • 67 citations

Current views on the mechanisms of pulmonary oedema

1978 • 67 citations

THE EFFECTS OF HEIGHTENED NEGATIVE PRESSURE IN THE CHEST, TOGETHER WITH FURTHER EXPERIMENTS UPON ANOXIA IN INCREASING THE FLOW OF LUNG LYMPH

1942 • 63 citations

Protein composition of lung fluids in anesthetized dogs with acute cardiogenic edema

1976 • 62 citations

The production and removal of oedema fluid in the lung after exposure to carbonyl chloride (phosgene)

1946 • 62 citations

Effects of Prostaglandin Cyclic Endoperoxides on the Lung Circulation of Unanesthetized Sheep

1979 • 61 citations

Salicylate pulmonary edema: the mechanism in sheep and review of the clinical literature.

1977 • 60 citations

Osmotic Extraction of Hypotonic Fluid from the Lungs

1974 • 59 citations

Innervation of pulmonary alveoli of the mouse lung: An electron microscopic study

1972 • 58 citations

The pathophysiology of pulmonary edema

1970 • 58 citations

Pulmonary interstitial and capillary pressures estimated from intra-alveolar fluid pressures

1978 • 57 citations

Reticuloendothelial Clearance of Blood-borne Particulates

1980 • 57 citations

Effect of platelet depletion on lung vascular permeability after microemboli in sheep

1980 • 56 citations

The anti‐inflammatory effect of catecholamines in the peritoneal cavity and hind paw of the mouse

1972 • 54 citations

Effect of positive pressure breathing on lung lymph flow and water content in sheep.

1978 • 53 citations

Alveolar pressure and lung volume as determinants of net transvascular fluid filtration

1977 • 53 citations

Pulmonary vascular transport in sheep

1976 • 52 citations

Prostaglandins and the lung

1977 • 52 citations

Steady state pulmonary transvascular water filtration in unanesthetized sheep.

1971 • 51 citations

Increased pulmonary vascular permeability follows intracranial hypertension in sheep.

1979 • 50 citations

Acute High-Altitude Illness in Mountaineers and Problems of Rescue

1973 • 50 citations

Effect of lung inflation on perivascular cuff fluid volume in isolated dog lung lobes

1979 • 50 citations

Lung vascular permeability: inferences from measurements of plasma to lung lymph protein transport.

1979 • 49 citations

Immunoelectron microscopic and immunochemical demonstrations of serum proteins in the alveolar lining material of the rat lung.

1976 • 48 citations

Significance of leukocytes in endotoxic shock

1975 • 48 citations

Functional development of the fetal lung

1966 • 47 citations

The relationship between pulmonary perivascular cuff fluid and lung lymph in dogs with edema

1980 • 47 citations

The structure of the interalveolar septum of the mammalian lung

1969 • 45 citations

Extravascular lung water after extracellular fluid volume expansion in dogs

1977 • 45 citations

Effect of heparin or fibrinogen depletion on lung fluid balance in sheep after emboli

1979 • 42 citations

ABSORPTION FROM THE PULMONARY ALVEOLI

1947 • 41 citations

Alveolar hypoxia increases lung fluid filtration in unanesthetized newborn lambs.

1980 • 40 citations

Zonulae occludentes in alveolar epithelium and capillary endothelium of dog lungs studied with the freeze—fracture technique

1976 • 40 citations

Pressure, serotonin, and histamine effects on lung multiple-indicator curves in sheep

1978 • 40 citations

Effect of edema on pulmonary blood flow in the isolated perfused dog lung lobe

1980 • 40 citations

Pulmonary oxygen toxicity: increased microvascular permeability to protein in unanesthetized lambs.

1979 • 39 citations

Pore models of sheep lung microvascular barrier using new data on protein tracers

1979 • 39 citations

Perivascular pressure measurements by wick-catheter technique in isolated dog lobes

1979 • 39 citations

Pulmonary Oedema

1955 • 38 citations

Role of bulk fluid flow in protein permeability of the dog lung alveolar membrane

1977 • 37 citations

STUDIES ON THE PATHOGENESIS OF AMMONIUM PULMONARY EDEMA

1949 • 37 citations

Permeability of muscle capillaries to interstitially microinjected horseradish peroxidase

1978 • 36 citations

Absorption from the lungs

1949 • 35 citations

Structural and functional reappraisal of the pulmonary artery system.

1968 • 32 citations

The dynamics of the lung fluid filtration system in dogs with edema.

1980 • 31 citations

THE EFFECT OF ANOXIA ON PULMONARY OEDEMA PRODUCED BY MASSIVE INTRAVENOUS INFUSIONS

1952 • 30 citations

Size of the pool of alveolar neutrophils in normal rabbit lungs

1979 • 30 citations

Pulmonary microvascular response to hemorrhagic shock, resuscitation, and recovery

1979 • 30 citations

The effects of alloxan and histamine on the permeability of the pulmonary alveolocapillary barrier to albumin

1969 • 30 citations

Regional distribution of extravascular water and hematocrit in the lung

1979 • 29 citations

Changes in the fluid compartments and dry weights of reimplanted dog lungs

1976 • 28 citations

Ultrastructural Studies of the Alveolar‐Capillary Barrier in Isolated Plasma‐Perfused Rabbit Lungs. Effects of EDTA and of Increased Capillary Pressure

1971 • 28 citations

Solute permeability of the alveolar epithelium in acute hemodynamic pulmonary edema in dogs

1977 • 27 citations

Distribution of interstitial compliance and filtration coefficient in canine lung.

1979 • 27 citations

A morphometric analysis of isolated perfused dog lungs after acute oncotic edema

1979 • 27 citations

Pathogenesis of pulmonary edema associated with the adult respiratory distress syndrome.

1979 • 25 citations

The Role of Leukocytes in Ethchlorvynol-Induced Pulmonary Edema

1978 • 22 citations

Aggregation fo blood platelets and increased hydraulic conductivity of pulmonary exchange vessels.

1976 • 20 citations

Intravascular platelet aggregation and acute respiratory insufficiency.

1977 • 19 citations

The effects of endogenous and exogenous histamine on pulmonary alveolar membrane permeability.

1978 • 17 citations

Amino-Acids and Sugars in Rectal Feeding

1913 • 17 citations

Regional extravascular lung water in normal sheep

1979 • 16 citations

Pulmonary damage following pulmonary microembolism in the dog. Effect of various types of treatment.

1976 • 16 citations

Respiratory Emergencies

1978 • 16 citations

Hemodynamic pulmonary edema in dogs with acute and chronic lymphatic ligation

1976 • 15 citations

Lung transvascular fluid dynamics with extracorporeal membrane oxygenation in unanesthetized lambs

1979 • 14 citations

Effects of Alveolar Surface Tension on the Pulmonary Vascular Bed

1966 • 14 citations

Isolated perfused dog lungs: A comparative stereologic comparison with normal dog lungs

1978 • 14 citations

Estimation of perimicrovascular fluid pressure in isolated perfused dog lung lobes

1979 • 14 citations

Pathogenesis of hemodynamic pulmonary edema in excised dog lungs.

1974 • 14 citations

Quantitative changes in permeability of rat lung epithelium in lung edema

1978 • 12 citations

Alveolar epithelium transport of albumin and sucrose: concentration difference effect

1979 • 12 citations

Effect of Lung Inflation on Alveolar Permeability to Solutes

1976 • 12 citations

Shock lung syndrome.

1981 • 11 citations

THE DROWNED LUNG

1961 • 10 citations

Effect of lung edema on pulmonary capillary pressure

1969 • 10 citations

Simple amplifier for oxygen electrodes.

1979 • 9 citations

Extravascular forces in lung affecting fluid and protein exchange.

1977 • 9 citations

Environmental injury of the lung: role of humoral mediators.

1978 • 7 citations

Chemical effects on lung transport.

1979 • 6 citations

Filtration von Fl�ssigkeit durch die Alveolar-Capillar-Schranke in der isolierten Hundelunge

1966 • 6 citations

Alveolar-Capillary Membrane Permeability

2015 • 5 citations

Lung fluids in acute ammonium chloride toxicity and edema in cats and guinea pigs

1973 • 5 citations

Effect of dihomo-gamma-linolenic acid on the canine pulmonary vascular bed

1978 • 4 citations

Interstitial Fluid and Transcapillary Fluid Balance in the Lung

1976 • 4 citations

Deleted Work

1955 • 0 citations