Clara cell protein (CC16): characteristics and potential applications as biomarker of lung toxicity

LABORATORY INVESTIGATION

1956 • 1,491 citations

The Journal of Laboratory and Clinical Medicine

2004 • 1,433 citations

THE AMERICAN JOURNAL OF PHYSIOLOGY

1897 • 904 citations

Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage.

1974 • 654 citations

LINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11q

1989 • 624 citations

British journal of industrial medicine

1989 • 432 citations

Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung

1977 • 359 citations

Role of the Clara cell in renewal of the bronchiolar epithelium.

1978 • 303 citations

Localisation of atopy and β subunit of high-affinity IgE receptor (Fc∈RI) on chromosome 11q

1993 • 294 citations

DOES T4 TOXICOSIS EXIST ?

1975 • 252 citations

Novel anti-inflammatory peptides from the region of highest similarity between uteroglobin and lipocortin I

1988 • 244 citations

Clara cell protein in serum and bronchoalveolar lavage

1992 • 205 citations

Uteroglobin inhibits phospholipase A2 activity

1986 • 200 citations

Identification, cellular localization, isolation, and characterization of human Clara cell-specific 10 KD protein.

1988 • 186 citations

Uteroglobin: Structure, Molecular Biology, and New Perspectives on Its Function as a Phospholipase A₂Inhibitor

1987 • 164 citations

Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers.

1984 • 162 citations

Potent inhibition of both human interferon-gamma production and biologic activity by the Clara cell protein CC16.

1995 • 147 citations

Clara cell protein (CC-16) induces a phospholipase A2-mediated inhibition of fibroblast migration in vitro.

1995 • 142 citations

Human Clara cell 10-kDa protein is the counterpart of rabbit uteroglobin.

1993 • 132 citations

Tissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.

1993 • 126 citations

Protein content in bronchoalveolar lavage fluid of patients with asthma and control subjects

1995 • 124 citations

Expression of surfactant associated protein-A and Clara cell 10 kilodalton mRNA in neoplastic and non-neoplastic human lung tissue as detected by in situ hybridization.

1992 • 117 citations

Clara cell 10 kDa protein (CC10): Comparison of structure and function to uterogloblin

1990 • 106 citations

An immunologic study of the secretory products of rat Clara cells.

1984 • 103 citations

Serum Clara Cell Protein: An Indicator of Bronchial Cell Dysfunction Caused by Tobacco Smoking

1994 • 102 citations

Potential role of Clara cell protein, an endogenous phospholipase A2 inhibitor, in acute lung injury

1995 • 100 citations

Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein

1988 • 98 citations

Early decrease of serum Clara cell protein in silica-exposed workers

1994 • 85 citations

Human urinary protein 1: Evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions

1992 • 77 citations

Metal buffer layers and Y-Ba-Cu-O thin films on Pt and stainless steel using pulsed laser deposition

1990 • 72 citations

Determination by latex immunoassay of protein 1 in normal and pathological urine

1991 • 69 citations

Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease

1995 • 64 citations

Cloning, structure, and expression of a rat binding protein for polychlorinated biphenyls. Homology to the hormonally regulated progesterone-binding protein uteroglobin.

1990 • 62 citations

The Role of the Nonciliated Bronchiolar Epithelial (Clara) Cell as the Progenitor Cell during Bronchiolar Epithelial Differentiation in the Perinatal Rabbit Lung

1992 • 61 citations

Purification and partial amino acid sequence of human urine protein 1

1988 • 59 citations

Ultrastructural localization of rat Clara cell 10 KD secretory protein by the immunogold technique using polyclonal and monoclonal antibodies.

1987 • 57 citations

Inhibition of pancreatic phospholipase A2 activity by uteroglobin and antiflammin peptides: Possible mechanism of action

1991 • 55 citations

Antigenic, molecular and functional heterogeneity of Clara cell secretory proteins in the rat

1985 • 52 citations

Assessment of urinary protein 1 and transferrin as early markers of cadmium nephrotoxicity.

1990 • 48 citations

Urine protein 1: a sex-dependent marker of tubular or glomerular dysfunction.

1989 • 48 citations

Secretory proteins of the lung in rodents: immunocytochemistry.

1985 • 46 citations

Eicosanoid levels in bronchoalveolar lavage fluid of young female smokers and non‐smokers

1992 • 43 citations

Clara Cell Protein (CC-16) and Surfactant-Associated Protein A (SP-A) in Asbestos-Exposed Workers

1996 • 42 citations

Low-molecular-weight proteins as markers of organ toxicity with special reference to Clara cell protein

1995 • 41 citations

Urinary protein 1 or Clara cell protein: a new sensitive marker of proximal tubular dysfunction.

1994 • 41 citations

Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals.

1984 • 39 citations

Clara Cell Protein in Human Amniotic Fluid: A Potential Marker of Fetal Lung Growth

1994 • 36 citations

Surfactant-producing rabbit pulmonary alveolar type II cells synthesize and secrete an antiinflammatory protein, uteroglobin

1992 • 34 citations

Purification and Level of Expression in Bronchoalveolar Lavage of a Human Polychlorinated Biphenyl (PCB)-binding Protein: Evidence for a Structural and Functional Kinship to the Multihormonally Regulated Protein Uteroglobin

1991 • 32 citations

Glucocorticoids induce the expression of the uteroglobin gene in rabbit foetal lung explants cultured in vitro

1985 • 30 citations

A Quantitative Assay for a Clara Cell-Specific Protein and Its Application in the Study of Development of Pulmonary Airways in the Rat

1986 • 29 citations

Silica directly increases permeability of alveolar epithelial cells

1990 • 28 citations

Clara cell cultures from the mouse and their reaction to bronchiolar toxins.

1990 • 27 citations

Clara Cell Cultures from the Mouse and Their Reaction to Bronchiolar Toxins

1990 • 21 citations

The Renal Handling of Protein 1 (Clara Cell Protein): Effect of Age, Sex and Renal Dysfunction

2015 • 20 citations

Early decrease of serum Clara cell in silica-exposed workers

1994 • 7 citations