Requirement for extracellular calcium or magnesium in mitogen‐induced activation of human peripheral blood lymphocytes

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes.

1983 • 466 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Monoclonal cytolytic T-cell lines.

1979 • 364 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

1984 • 351 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides

1975 • 270 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

1985 • 223 citations

Calcium Influx Requirement for Human Neutrophil Chemotaxis: Inhibition by Lanthanum Chloride

1976 • 222 citations

CALCIUM EXPLOSIONS AS TRIGGERS OF DEVELOPMENT

1980 • 182 citations

Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

1984 • 175 citations

Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin 2 but not for expression of the interleukin 2 receptor.

1985 • 164 citations

Kinetics of reaction in calcium-activated skinned muscle fibres

1976 • 158 citations

Transmembrane signaling during interleukin 1-dependent T cell activation. Interactions of signal 1- and signal 2-type mediators with the phosphoinositide-dependent signal transduction mechanism.

1987 • 157 citations

The interference of T cell activation by calcium channel blocking agents.

1984 • 156 citations

Transmembrane Ion Fluxes during Activation of Human T Lymphocytes: Role of Ca²⁺, Na⁺/H⁺ Exchange and Phospholipid Turnover

1987 • 154 citations

The role of calcium in lymphocyte proliferation. (An interpretive review)

1983 • 151 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin

1972 • 151 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

1986 • 139 citations

Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride.

1987 • 139 citations

The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes

1985 • 120 citations

Calcium‐dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter

1983 • 120 citations

Induction of expression and phosphorylation of the human interleukin 2 receptor by a phorbol diester.

1984 • 116 citations

Interleukin 2-induced lymphocyte proliferation is independent of increases in cytosolic-free calcium concentrations.

1985 • 113 citations

Antigen-induced increase in protein kinase C activity in plasma membrane of mast cells.

1985 • 104 citations

Ionomycin stimulates mast cell histamine secretion by forming a lipid-soluble calcium complex

1979 • 84 citations

A survey of readily available chelators for buffering calcium ion concentrations in physiological solutions

1983 • 81 citations

Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein.

1986 • 78 citations

Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.

1986 • 75 citations

Phytohemagglutinin induces rapid degradation of phosphatidylinositol 4,5-bisphosphate and transient accumulation of phosphatidic acid and diacylglycerol in a human T lymphoblastoid cell line, CCRF-CEM.

1983 • 65 citations

Role of membrane potential in the response of human T lymphocytes to phytohemagglutinin.

1987 • 60 citations

Evidence for an interleukin-independent pathway for human lymphocyte activation.

1983 • 58 citations

The Sheep Erythrocyte Receptor and Both α and β Chains of the Human T‐Lymphocyte Antigen Receptor Bind the Mitogenic Lectin (Phytohaemagglutinin) from Phaseolus vulgaris

1986 • 54 citations

Phytohemagglutinin induces rapid degradation of phosphatidylinositol 4, 5-bisphosphate and transient accumulation of phosphatidic acid and diacylglycerol in a human T lymphoblastoid cell line, CCRF-CEM

1983 • 48 citations

The role of the accessory cell in mitogen-stimulated human T cell gene expression.

1986 • 44 citations

Ca2+ ionophores and the activation of human blood platelets

1980 • 36 citations

Phytohemagglutinin treatment of T lymphocytes stimulates rapid increases in activity of both particulate and cytosolic protein kinase C

1986 • 32 citations

The effect of [Mg2+] on the Ca2+ dependence of ATPase and tension development of fast skeletal muscle. The role of the Ca2+-specific sites of troponin C.

1987 • 24 citations

Intracellular calcium activity in split frog skin epithelium: Effect of cAMP

1985 • 20 citations

Cytosol Mg²⁺ modulates Ca²⁺ ionophore induced secretion from rabbit neutrophils

1983 • 20 citations

Extracellular Ca2+ requirement for initiation of lymphocyte growth

1980 • 13 citations