Tiagabine: Efficacy and Safety in Adjunctive Treatment of Partial Seizures

328. Note: The Use of None-Parametric Methods in the Statistical Analysis of the Two-Period Change-Over Design

1972 • 470 citations

Antiepileptic Drugs

1996 • 381 citations

New Antiepileptic Drugs

1996 • 344 citations

A Review of the Preclinical Pharmacology of Tiagabine: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor

1995 • 277 citations

Update on the Mechanism of Action of Antiepileptic Drugs

1996 • 256 citations

(R)‐N‐[4,4‐Bis(3‐Methyl‐2‐Thienyl)but‐3‐en‐1‐yl]Nipecotic Acid Binds with High Affinity to the Brain γ‐Aminobutyric Acid Uptake Carrier

1990 • 228 citations

GABA uptake inhibitors: relevance to antiepileptic drug research

1987 • 179 citations

The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidate

1993 • 147 citations

Adjunctive treatment of partial seizures with tiagabine: A placebo-controlled trial

1995 • 98 citations

Pharmacokinetics of Tiagabine, a γ‐Aminobutyric Acid‐Uptake Inhibitor, in Healthy Subjects After Single and Multiple Doses

1995 • 98 citations

Controlled trial of sodium valproate in severe epilepsy.

1975 • 97 citations

Valproate Sodium: A Controlled Clinical Trial Including Monitoring of Drug Levels

1977 • 96 citations

Basic Mechanisms of Gabitril (Tiagabine) and Future Potential Developments

1999 • 89 citations

β₁‐Adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea

1990 • 44 citations

A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.

1986 • 30 citations

Lack of a Clinically Significant Pharmacokinetic Drug Interaction Between Tiagabine and Valproate

1998 • 22 citations

Lack of Pharmacokinetic Drug Interactions Between Tiagabine and Carbamazepine or Phenytoin

1998 • 21 citations

Anticonvulsant action of tiagabine, a new GABA-uptake inhibitor

1994 • 20 citations

Rational basis for the development of new antiepileptic drugs.

1991 • 15 citations

New Drug Treatments in Epilepsy

1994 • 7 citations

Lack of clinically important drug reactions between tiagabine and carbamazepine, phenytoin or valproate

1995 • 5 citations

Efficacy of tiagabine (Gabitril) in all partial seizure types

1997 • 1 citations

Deleted Work

1955 • 0 citations