Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone

Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide

1991 • 3,211 citations

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

1993 • 2,034 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

1987 • 1,275 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Peptide nucleic acids (PNA). Oligonucleotide analogs with an achiral peptide backbone

1992 • 723 citations

Antisense and Antigene Properties of Peptide Nucleic Acids

1992 • 538 citations

Second Structural Motif for Recognition of DNA by Oligonucleotide-Directed Triple-Helix Formation

1991 • 530 citations

Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-(α]-thymidylate covalently linked to an azidoproflavine derivative

1987 • 488 citations

Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation

1989 • 416 citations

Recognition of guanine and adenine in DNA by cytosine and thymine containing peptide nucleic acids (PNA)

1992 • 264 citations

Specific inhibition of transcription by triple helix-forming oligonucleotides.

1992 • 241 citations

Binding of triple helix forming oligonucleotides to sites in gene promoters

1991 • 240 citations

Recognition of Thymine Adenine Base Pairs by Guanine in a Pyrimidine Triple Helix Motif

1989 • 218 citations

DNA unwinding upon strand-displacement binding of a thymine-substituted polyamide to double-stranded DNA.

1993 • 194 citations

Triple helix formation inhibits transcription elongation in vitro.

1991 • 171 citations

A triple helix-forming oligonucleotide-intercalator conjugate acts as a transcriptional repressor via inhibition of NF kappa B binding to interleukin-2 receptor alpha-regulatory sequence.

1992 • 169 citations

Sequence specific inhibition of DNA restriction enzyme cleavage by PNA

1993 • 163 citations

Sequence selective double strand DNA cleavage by Peptide Nucleic Acid (PNA) targeting using nuclease S1

1993 • 157 citations

Inhibition of gene expression by triple helix-directed DNA cross-linking at specific sites.

1993 • 154 citations

Inhibition of restriction endonuclease cleavage via triple helix formation by homopyrimidine oligonucleotides

1989 • 133 citations

Peptide nucleic acids (PNAs): potential antisense and anti-gene agents.

1993 • 116 citations

An anti-parallel triple helix motif with oligodeoxynucleotidescontaining 2'-deoxyguanosine and 7-deaza-2'-deoxy xanthosine

1993 • 99 citations

Sequence-selective DNA recognition by synthetic ligands

1991 • 99 citations

Synthesis and binding properties of pyrimidine oligodeoxynucleoside analogs containing neutral phosphodiester replacements: the formacetal and 3'-thioformacetal internucleoside linkages

1993 • 95 citations

Flanking sequence effects within the pyrimidine triple-helix motif characterized by affinity cleaving

1992 • 90 citations

Specific recognition of CG base pairs by 2-deoxynebularine within the purine.cntdot.purine.cntdot.pyrimidine triple-helix motif

1993 • 67 citations

Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences

1993 • 55 citations

Sequence-selective recognition and cleavage of double-helical DNA

1993 • 51 citations

Intramolecular triple-helix formation at (PunPyn).cntdot.(PunPyn) tracts: recognition of alternate strands via Pu.cntdot.PuPy and Py.cntdot.PuPy base triplets

1992 • 50 citations

Acyclic nucleic acid analogs: synthesis and oligomerization of .gamma.,4-diamino-2-oxo-1(2H)-pyrimidinepentanoic acid and .delta.,4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

1991 • 26 citations

Modification of the binding affinity of peptide nucleic acids (PNA). PNA with extended backbones consisting of 2-aminoethyl-β-alanine or 3-aminopropylglycine units

1993 • 25 citations