Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Running enhances neurogenesis, learning, and long-term potentiation in mice

1999 • 2,829 citations

Neuronal replacement from endogenous precursors in the adult brain after stroke

2002 • 2,731 citations

Neural consequences of enviromental enrichment

2000 • 2,376 citations

Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

1997 • 1,880 citations

Transient expression of doublecortin during adult neurogenesis

2003 • 1,485 citations

The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography

1991 • 1,090 citations

Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat

2001 • 1,048 citations

Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils

1998 • 1,031 citations

Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

2002 • 1,013 citations

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo

2004 • 816 citations

VEGF links hippocampal activity with neurogenesis, learning and memory

2004 • 815 citations

Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

2003 • 788 citations

Evidence for a Two-Stage Model of Spatial Working Memory Processing within the Lateral Frontal Cortex: A Positron Emission Tomography Study

1996 • 760 citations

The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis

2002 • 752 citations

Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells

2004 • 656 citations

Enriched Rehabilitative Training Promotes Improved Forelimb Motor Function and Enhanced Dendritic Growth after Focal Ischemic Injury

2001 • 605 citations

A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction.

1986 • 588 citations

Use-dependent growth of pyramidal neurons after neocortical damage

1994 • 513 citations

Planning and Spatial Working Memory: a Positron Emission Tomography Study in Humans

1996 • 454 citations

Effects of differential experience on dendritic spine counts in rat cerebral cortex.

1973 • 441 citations

Doublecortin expression in the adult rat telencephalon

2001 • 422 citations

Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus

1998 • 385 citations

Environment Influences Functional Outcome of Cerebral Infarction in Rats

1995 • 322 citations

Environment, Social Interaction, and Physical Activity as Determinants of Functional Outcome after Cerebral Infarction in the Rat

1996 • 310 citations

Physical exercise and brain monoamines: a review

1989 • 309 citations

N‐methyl‐<scp>d</scp>‐aspartate receptor‐mediated increase of neurogenesis in adult rat dentate gyrus following stroke

2001 • 306 citations

Hypoxia-Ischemia Induces DNA Synthesis without Cell Proliferation in Dying Neurons in Adult Rodent Brain

2004 • 272 citations

Neuronal Plasticity and Dendritic Spines: Effect of Environmental Enrichment on Intact and Postischemic Rat Brain

2002 • 259 citations

Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice

1993 • 255 citations

Enriched Environment Increases Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Subventricular Zone of Stroke-Lesioned Adult Rats

2005 • 247 citations

Experience-dependent regulation of adult hippocampal neurogenesis: Effects of long-term stimulation and stimulus withdrawal

1999 • 244 citations

Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits

2004 • 217 citations

Hypoglycemic Neuronal Death and Cognitive Impairment Are Prevented by Poly(ADP-Ribose) Polymerase Inhibitors Administered after Hypoglycemia

2003 • 201 citations

Is impaired neurogenesis relevant to the affective symptoms of depression?

2004 • 187 citations

Depression in neurological disorders: Parkinson's disease, multiple sclerosis, and stroke

2005 • 186 citations

Functional Outcome in Rats Transferred to an Enriched Environment 15 Days After Focal Brain Ischemia

1996 • 180 citations

Altered synaptic transmission in dentate gyrus of rats reared in complex environments: evidence from hippocampal slices maintained in vitro

1986 • 179 citations

NMDA and AMPA/Kainate Glutamate Receptors Modulate Dentate Neurogenesis and CA3 Synapsin-I in Normal and Ischemic Hippocampus

2000 • 169 citations

Increased Proliferation of Neural Progenitor Cells but Reduced Survival of Newborn Cells in the Contralateral Hippocampus after Focal Cerebral Ischemia in Rats

2002 • 159 citations

Environmental enrichment reverses learning impairment in the Morris water maze after focal cerebral ischemia in rats

2004 • 138 citations

Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus

1998 • 130 citations

Postischemic exercise attenuates whereas enriched environment has certain enhancing effects on lesion‐induced subventricular zone activation in the adult rat

2005 • 121 citations

Effects of Cortical Ischemia and Postischemic Environmental Enrichment on Hippocampal Cell Genesis and Differentiation in the Adult Rat

2002 • 114 citations

Serotonin and neurogenesis in the hippocampal dentate gyrus of adult mammals

2004 • 101 citations

Functional and cellular effects of environmental enrichment after experimental brain infarcts

2004 • 97 citations

Frontal-lobe involvement in spatial memory: evidence from PET, fMRI, and lesion studies.

2000 • 70 citations

Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke

2001 • 69 citations

Effects of postischemic environment on transcription factor and serotonin receptor expression after permanent focal cortical ischemia in rats

2003 • 67 citations

Brain noradrenergic responses to footshock after chronic activity-wheel running.

1999 • 66 citations

Social interactions among rats housed in grouped and enriched conditions

1986 • 63 citations

Brain noradrenergic responses to footshock after chronic activity-wheel running.

1999 • 62 citations

Hypoglycemia Induces Transient Neurogenesis and Subsequent Progenitor Cell Loss in the Rat Hippocampus

2005 • 57 citations

Functional Brain Mapping of the Macaque Related to Spatial Working Memory as Revealed by PET

2003 • 51 citations

In vivo opioid receptor occupation in the rat brain following exercise.

1986 • 49 citations

In vivo opioid receptor occupation in the rat brain following exercise

1986 • 45 citations

Influence of the postlesion environment and chronic piracetam treatment on the organization of the somatotopic map in the rat primary somatosensory cortex after focal cortical injury

2003 • 43 citations

Metabolic Activation Pattern of Distinct Hippocampal Subregions during Spatial Learning and Memory Retrieval

2005 • 32 citations

Environmental Influence on Outcome After Experimental Brain Infarction

1996 • 23 citations

Traumatic Brain Injury

2003 • 9 citations

Neuroprotective Effects on Somatotopic Maps Resulting from Piracetam Treatment and Environmental Enrichment After Focal Cortical Injury

2003 • 9 citations

Poststroke Depression: Psychopharmacological Considerations

2004 • 5 citations