Sterol, Structure and Membrane Function

Evolution and Tinkering

1977 • 2,509 citations

The function of sterols in membranes

1976 • 1,330 citations

Dynamic structure of fatty acyl chains in a phospholipid bilayer measured by deuterium magnetic resonance

1974 • 962 citations

The Hopanoids: palaeochemistry and biochemistry of a group of natural products

1979 • 751 citations

Microviscosity parameters and protein mobility in biological membranes

1976 • 686 citations

Difference in microviscosity induced by different cholesterol levels in the surface membrane lipid layer of normal lymphocytes and malignant lymphoma cells

1974 • 633 citations

Dynamics of lipids in membranes: Heterogeneity and the role of cholesterol

1972 • 526 citations

The Biological Synthesis of Cholesterol

1965 • 524 citations

Structural analysis of hydrated egg lecithin and cholesterol bilayers I. X-ray diffraction

1976 • 516 citations

Biochemistry of steroids and other isopentenoids

1977 • 489 citations

The utilization of sterols by insects

1964 • 442 citations

Spectroscopic studies of specifically deuterium labeled membrane systems. Nuclear magnetic resonance investigation of the effects of cholesterol in model systems

1978 • 405 citations

Anaerobic nutrition of saccharomyces cerevisiae. II. Unsaturated fatty and requirement for growth in a defined medium

1954 • 391 citations

The effect of sterol structure on the permeability of lipomes to glucose, glycerol and Rb+

1972 • 354 citations

Molecular evolution of biomembranes: structural equivalents and phylogenetic precursors of sterols.

1979 • 313 citations

Steroids and Squalene in Methylococcus capsulatus grown on Methane

1971 • 284 citations

Plasma-Membrane lipid composition and ethanol tolerance inSaccharomyces cerevisiae

1978 • 283 citations

Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol.

1967 • 271 citations

The Absence of Sterol Synthesis in Insects

1959 • 264 citations

Role of sterols in membranes

1974 • 260 citations

Characterization of a polyisoprenoid compound functional in O-antigen biosynthesis.

1967 • 231 citations

Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene.

1977 • 231 citations

Model of interaction of polar lipids, cholesterol, and proteins in biological membranes

1974 • 212 citations

Squalenes, phytanes and other isoprenoids as major neutral lipids of methanogenic and thermoacidophilic “archaebacteria”

1979 • 192 citations

Molecular Biology of Bacterial Membrane lipids

1978 • 188 citations

Metabolism of Sterols in Yeast

1978 • 187 citations

Effects of cholesterol and cholesterol derivatives on hydrocarbon chain mobility in lipids

1971 • 184 citations

Δ8(14)-steroids in the bacterium Methylococcus capsulatus

1976 • 175 citations

Molecular Mechanism for the Interaction of Phospholipid with Cholesterol

1972 • 166 citations

The functional importance of structural features of ergosterol in yeast.

1978 • 160 citations

Biomimetic polyene cyclizations

1976 • 157 citations

Headgroup conformation and lipid--cholesterol association in phosphatidylcholine vesicles: a 31P(1H) nuclear Overhauser effect study.

1975 • 152 citations

Isolation and Characterization of Bacteria That Grow on Methane and Organic Compounds as Sole Sources of Carbon and Energy

1974 • 148 citations

Insect Nutrition

1956 • 143 citations

Biosynthesis of sterols, steroids, and terpenoids. Part I. Biogenesis of cholesterol and the fundamental steps in terpenoid biosynthesis

1965 • 140 citations

The Isolation of a Pentacyclic Triterpenoid Alcohol from a Protozoan

1963 • 139 citations

Mortality of Thick-billed Murres in the West Greenland Salmon Fishery

1972 • 137 citations

Dinosterol, the major sterol with a unique side chain in the toxic dinoflagellate, Gonyaulax tamarensis

1976 • 128 citations

Function of Sterols in Dermestes vulpinus

1959 • 122 citations

Absence of filipin-sterol complexes from large coated pits on the surface of culture cells.

1979 • 122 citations

Differential effects of cholesterol and lanosterol on artificial membranes.

1977 • 120 citations

Cholesterol in the Growth of Organisms of the Pleuropneumonia Group

1951 • 115 citations

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching

1978 • 113 citations

Sterols: Isolation from a Blue-Green Alga

1968 • 112 citations

Phospholpid studies of marine organisms: 2.¹ Phospholipids, phospholipid‐bound fatty acids and free sterols of the spongeAplysina fistularis (Pallas) formafulva (Pallas) (=Verongia thiona)². Isolation and structure elucidation of unprecedented branched fatty acids

1981 • 110 citations

A glycolipid containing hopane isolated from the acidophilic, thermophilic bacillus acidocaldarius, has a cholesterol‐like function in membranes

1980 • 107 citations

CURRENT TOPICS IN CELLULAR REGULATION

1996 • 107 citations

Roles of carbonyl oxygens at the bilayer interface in phospholipid–sterol interaction

1976 • 102 citations

Membrane lipids of mycoplasmas

1980 • 102 citations

Occurrence of squalene, di- and tetrahydrosqualenes, and vitamin MK8 in an extremely halophilic bacterium, Halobacterium cutirubrum

1969 • 101 citations

On a fat-soluble growth factor required by blow-fly larvae

1935 • 100 citations

Phytanyl-glycerol ethers and squalenes in the archaebacteriumMethanobacterium thermoautotrophicum

1978 • 93 citations

Catabolite Repression of Tryptophanase in Escherichia coli

1971 • 92 citations

Recent progress in the marine sterol field

1979 • 90 citations

Sterols in membranes: growth characteristics and membrane properties of Mycoplasma capricolum cultured on cholesterol and lanosterol

1980 • 90 citations

Stringent Control of Fatty Acid Synthesis in Escherichia coli

1973 • 90 citations

Effect of alkyl-substituted precursors of cholesterol on artificial and natural membranes and on the viability of Mycoplasma capricolum

1980 • 88 citations

The influence of lecithin structure on their monolayer behavior and interactions with cholesterol

1973 • 88 citations

Physiology of Mycoplasmas

1973 • 87 citations

La biosynthèse des stérols dans les tissus de tabac cultivés in vitro—II.

1966 • 84 citations

Conversion of Ergosterol to 22-Dehydrocholesterol in Blattella germanica

1959 • 82 citations

Structure in the polar head region of phospholipid bilayers: a phosphorus-31 {proton} nuclear Overhauser effect study

1976 • 82 citations

Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase.

1981 • 81 citations

Plant Sterol Metabolism

1974 • 79 citations

Non‐specific Lanosterol and Hopanoid Biosynthesis by a Cell‐Free System from the Bacterium Methylococcus capsulatus

1980 • 75 citations

The structure of bactoprenol, a lipid formed by lactobacilli from mevalonic acid

1966 • 74 citations

SYNTHESIS OF LANOSTEROL IN VIVO

1957 • 72 citations

The isolation and identification of two sterols from two species of Blue-green Algae

1968 • 72 citations

Yeast mutants blocked in removing the methyl group of lanosterol at C-14. Separation of sterols by high-pressure liquid chromatography

1977 • 71 citations

State of molecular motion of cholesterol in lecithin bilayers

1975 • 70 citations

Effect of cholesterol on macromolecular synthesis and fatty acid uptake by Mycoplasma capricolum.

1981 • 68 citations

Sterol Requirements of T-Strain Mycoplasmas

1971 • 68 citations

Effect of sterol replacement in vivo on the fatty acid composition of Tetrahymena.

1975 • 64 citations

Isolation of a New Acetate-replacing Factor

1956 • 62 citations

Isolation and partial characterization of a cholesterol-requiring mutant of Chinese hamster ovary cells.

1977 • 61 citations

ESR determination of membrane order parameter in yeast sterol mutants

1979 • 58 citations

Sterol requirement of Mycoplasma capricolum.

1978 • 55 citations

Effects of phospholipid acyl chain structure on thermotropic phase properties. 3. Phosphatidylcholines with (−), and (±)-anteiso acyl chains

1980 • 54 citations

Marine sterols: 19-nor-stanols from the sponge Axinella polypoides

1974 • 54 citations

Effect of sterol depletion on LM cell sterol mutants. Changes in the lipid composition of the plasma membrane and their effects on 3-O-methlglucose transport.

1979 • 54 citations

Cyclization of 2,3-oxidosqualene to cycloartenol in a cell-free system from higher plants

1968 • 52 citations

Effect of sterol side chains on growth and membrane fatty acid composition of Saccharomyces cerevisiae

1980 • 52 citations

Ketonic Intermediates in the Demethylation of Lanosterol

1963 • 51 citations

Involvement of cytochrome P-450 and a cyanide-sensitive enzyme in different steps of lanosterol demethylation by yeast microsomes

1978 • 50 citations

Studies on Tetrahymena membranes

1975 • 50 citations

The importance of the phospholipid bilayer and the length of the cholesterol molecule in membrane structure

1979 • 48 citations

A Hopanoid from the thermo-acidophilic Bacillus acidocaldarius condenses membranes

1980 • 48 citations

THE COMPOSITION OF MEMBRANE LIPIDS AND LIPOPOLYSACCHARIDES

1979 • 48 citations

Impaired steroid biogenesis in insect larvae

1956 • 47 citations

The Effects of Catabolite Derepression on the Accumulation of Steryl Esters and the Activity of -Hydroxymethylglutaryl-CoA Reductase in Saccharomyces cerevisiae

1979 • 47 citations

A spin label study of the effects of sterols on egg lecithin bilayers

1979 • 45 citations

The Rôle of Cytochrome P‐450 in Cholesterol Biosynthesis

1973 • 44 citations

Dehydrogenation and dealkylation of various sterols byTetrahymena pyriformis

1971 • 43 citations

On the role of the sterol hydroxyl group in membranes.

1979 • 43 citations

The effect of some alkyl derivatives of cholesterol on the permeability properties and microviscosities of model membranes

1978 • 39 citations

Ergosterol replacement of tetrahymanol in Tetrahymena membranes

1971 • 39 citations

Utilization and metabolism of methyl-sterol derivatives in the yeast mutant strain GL7

1981 • 39 citations

Phosphatidylcholine liposomes containing cholesterol analogues with side chains of various lengths

1980 • 39 citations

Sterol requirements of a ciliate Tetrahymena corlissi Th-X

1961 • 38 citations

Comparative responses of the yeast mutant strain GL7 to lanosterol, cycloartenol, and cyclolaudenol

1980 • 37 citations

Effect of sterol structure on acyl chain ordering in phosphatidylcholine vesicles: a deuterium nuclear magnetic resonance and electron spin resonance study

1981 • 37 citations

Effects of cycloartenol and lanosterol on artificial and natural membranes

1980 • 37 citations

Evidence for a nonoxidative cyclization of squalene in the biosynthesis of tetrahymanol

1968 • 37 citations

The Nutrition of Tetrahymena setifera HZ‐1; Sterol and Alcohol Requirements

1962 • 34 citations

Tetrahymanol Biosynthesis

1970 • 33 citations

Removal of the 4,4-Dimethyl Carbons in the Enzymic Conversion of Lanosterol to Cholesterol

1970 • 33 citations

Biological demethylation of 4,4-dimethyl sterols. Initial removal of the 4.alpha.-methyl group

1968 • 31 citations

Metabolism in porifera-V, biosynthesis of 19-Nor-Stanols: Conversion of cholesterol into 19-nor-cholestanols by the spongeAxinella polypoides

1975 • 31 citations

The synthesis of tetrahymanol

1965 • 27 citations

Presence and synthesis of cholesterol in stable staphylococcal L-forms

1979 • 26 citations

Modification of the Membrane Composition of Mycoplasma mycoides subsp. capri by the Growth Medium

1975 • 26 citations

Biological demethylation of 4,4-dimethyl sterols. Evidence for enzymic epimerization of the 4.beta.-methyl group prior to its oxidative removal

1969 • 26 citations

The steric requirements for the metabolism of sterols by Tetrahymena pyriformis.

1978 • 25 citations

Triterpenes from Mosses—I

1968 • 25 citations

ON THE EVOLUTION OF A BIOSYNTHETIC PATHWAY

1976 • 25 citations

Metabolism of Δ²⁴-sterols by yeast mutants blocked in removal of the C-14 methyl group

1978 • 24 citations

Presence of squalene in gram-positive bacteria

1978 • 23 citations

Nonoxidative cyclization of squalene by Tetrahymena pyriformis. Incorporation of a 3.beta. hydrogen (deuterium) atom into tetrahymanol

1979 • 22 citations

Fate of Beta-Sitosterol in Housefly Larvæ

1958 • 21 citations

Quantitative aspects of free and esterified sterols in Saccharomyces cerevisiae under various conditions

1978 • 20 citations

Occurrence of 19-nor cholesterol and homologs in marine animals

1976 • 20 citations

Anerobische Cyclisierung von Squalen-2,3-epoxyd zu Cycloartenol in Gewebekulturen von Nicotiana tabacum L.

1969 • 19 citations

Occurrence of squalene in methanol-grown bacteria

1978 • 18 citations

Occurrence of squalene and sterols in Cellulomonas dehydrogenans (Arnaudi 1942) comb. nov. Hester 1971

1978 • 13 citations

The use of lipid mutants of Saccharomyces cerevisiae to investigate the role of unsaturated fatty acids and sterols in membrane functions

1980 • 11 citations

Enzymic transformation of an acyclic sesterterpene terminal epoxide into a lanosterol analogue

1969 • 11 citations

Measurement in vitro of the esterification of yeast sterols

1978 • 7 citations

Studies on squalene synthetase from Tetrahymena pyriformis

1981 • 1 citations

Excerpts from an Interview with Sir Hans Krebs

1981 • 1 citations