Endothelial NO synthase gene polymorphisms and risk of ischemic stroke: A meta-analysis

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

Meta-analysis in clinical trials

1986 • 36,193 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Replication validity of genetic association studies

2001 • 1,845 citations

Genetic data analysis II: methods for discrete population genetic data

1996 • 1,691 citations

Experience from a multicentre stroke register: a preliminary report.

1976 • 1,499 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

1996 • 713 citations

Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298

2000 • 527 citations

Epidemiological methods for studying genes and environmental factors in complex diseases

2001 • 473 citations

Genetics and ischaemic stroke

2000 • 394 citations

Meta-analysis of Genetic Studies in Ischemic Stroke

2004 • 385 citations

Systematic Evaluation and Comparison of Statistical Tests for Publication Bias

2005 • 313 citations

Endothelial Nitric Oxide Synthase Genotype and Ischemic Heart Disease

2004 • 297 citations

Genetic Contribution of the Endothelial Constitutive Nitric Oxide Synthase Gene to Plasma Nitric Oxide Levels

1997 • 294 citations

Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease: A HuGE Review

2006 • 242 citations

The paradoxical relationship between serum uric acid and cardiovascular disease

2008 • 235 citations

Glu298Asp Endothelial Nitric Oxide Synthase Gene Polymorphism Interacts With Environmental and Dietary Factors to Influence Endothelial Function

2002 • 183 citations

Modifier effect of ENOS in autosomal dominant polycystic kidney disease

2002 • 175 citations

Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease

2004 • 159 citations

Endothelial Nitric Oxide Synthase Exon 7 Polymorphism, Ischemic Cerebrovascular Disease, and Carotid Atheroma

1998 • 150 citations

Association Between the Glu298Asp Polymorphism in the Endothelial Constitutive Nitric Oxide Synthase Gene and Brain Infarction

2000 • 116 citations

Endothelial NO Synthase Gene Polymorphisms and Hypertension

2006 • 102 citations

Endothelial Nitric Oxide Synthase Gene Polymorphism and Maternal Vascular Adaptation to Pregnancy

2001 • 98 citations

Promoter Polymorphisms in the Nitric Oxide Synthase 3 Gene Are Associated With Ischemic Stroke Susceptibility in Young Black Women

2005 • 80 citations

The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case–control studies

2006 • 80 citations

The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat

1997 • 79 citations

Nitric Oxide Deficiency as a Cause of Clinical Hypertension

2001 • 76 citations

Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke

2004 • 63 citations

Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients

2001 • 62 citations

The 27-bp repeat polymorphism in intron 4 of the endothelial cell nitric oxide synthase gene and ischemic stroke in a Japanese population

1998 • 60 citations

No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

1999 • 51 citations

The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke

2008 • 37 citations

Effect of polymorphisms of endothelial nitric oxide synthase on ischemic stroke: A case-control study in a Chinese population

2008 • 35 citations

NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: The Atherosclerosis Risk in Communities study

2006 • 29 citations

The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans

2007 • 20 citations

Association between polymorphisms of ACE, B2AR, ANP and ENOS and cardiovascular diseases: a community-based study in the Matsu area

2007 • 11 citations

Analysis of the Endothelial Nitric Oxide Synthase Gene as a Modifier of the Cerebral Response to Ischemia

2006 • 9 citations

ASSOCIATION BETWEEN A VARIABLE NUMBER OF TANDEM REPEAT POLYMORPHISM OF THE ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE WITH ISCHEMIC CEREBROVASCULAR DISEASE

2004 • 5 citations

Association between the G894T polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction

2004 • 5 citations

Study of a 27-bp variable number of tandem repeat polymorphism of the endothelial nitric oxide synthase gene in patients with transient ischemic attack of brain

2005 • 3 citations

Association study between a polymorphism of endothelial nitric oxide synthase gene and ischemic stroke

2007 • 2 citations

Relationship between eNOS gene G894T mutation and ischemic stroke

2000 • 1 citations