The use of triazine inhibitors in mapping the active site region of Lactobacillus casei dihydrofolate reductase

Partition coefficients and their uses

1971 • 4,444 citations

Aromatic substituent constants for structure-activity correlations

1973 • 1,189 citations

Substituent constants for correlation analysis

1977 • 396 citations

Dihydrofolate Reductase: X-ray Structure of the Binary Complex with Methotrexate

1977 • 323 citations

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

1978 • 229 citations

Quantitative structure-activity relations. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character

1977 • 194 citations

Structure-activity correlations for antibacterial agents on gram-positive and gram-negative cells

1968 • 146 citations

Affinity chromatography of dihydrofolate reductase

1971 • 51 citations

Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration

1977 • 36 citations

Dihydrofolate reductase inhibition by 2,4-diaminotriazines: A structure-activity study

1979 • 16 citations