Genome annotation by high-throughput 5′ RNA end determination

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

<tt>BLAT</tt>—The <tt>BLAST</tt>-Like Alignment Tool

2002 • 8,153 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Serial Analysis of Gene Expression

1995 • 3,659 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

A vision for the future of genomics research

2003 • 1,721 citations

The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics

2003 • 964 citations

Genome-wide detection of alternative splicing in expressed sequences of human genes

2001 • 688 citations

A trans-spliced leader sequence on actin mRNA in C. elegans

1987 • 639 citations

Using the transcriptome to annotate the genome

2002 • 637 citations

Evidence for Trans splicing in trypanosomes

1986 • 486 citations

Annotation of the Drosophila melanogastereuchromatic genome: a systematic review

2002 • 377 citations

C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression

2003 • 366 citations

A global analysis of Caenorhabditis elegans operons

2002 • 359 citations

Operons as a common form of chromosomal organization in C. elegans

1994 • 245 citations

High-throughput SELEX–SAGE method for quantitative modeling of transcription-factor binding sites

2002 • 210 citations

Short leader sequences may be transferred from small RNAs to pre-mature mRNAs by trans-splicing in Euglena.

1991 • 181 citations

TRANS-SPLICING OF NEMATODE PREMESSENGER RNA

1993 • 163 citations

mRNA 5′-leader trans-splicing in the chordates

2001 • 146 citations

A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni.

1990 • 144 citations

The C. elegans Trans-spliced leader RNA is bound to Sm and has a trimethylguanosine cap

1988 • 139 citations

Expressed sequence tags — ESTablishing bridges between genomes

1998 • 131 citations

Insertion of part of an intron into the 5' untranslated region of a Caenorhabditis elegans gene converts it into a trans-spliced gene.

1991 • 100 citations

Trans splicing of nematode pre-messenger RNA in vitro

1990 • 93 citations

Assessment of SAGE in Transcript Identification

2003 • 76 citations

Gene Counters Struggle to Get the Right Answer

2003 • 74 citations

C.elegansmRNAs acquire a spliced leader through atrans-splicing mechanism

1988 • 65 citations

Conversion of a trans-spliced C. elegans gene into a conventional gene by introduction of a splice donor site.

1993 • 58 citations

SL1 trans-splicing specified by AU-rich synthetic RNA inserted at the 5' end of Caenorhabditis elegans pre-mRNA.

1995 • 43 citations

WorfDB: the Caenorhabditis elegans ORFeome Database

2003 • 37 citations

Insertion of Part of an Intron into the 5′ Untranslated Region of a Caenorhabditis elegans Gene Converts It into a Zraws-Spliced Gene

1991 • 32 citations