Tellurium Blocks Cholesterol Synthesis by Inhibiting Squalene Metabolism: Preferential Vulnerability to This Metabolic Block Leads to Peripheral Nervous System Demyelination

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Phosphorus Assay in Column Chromatography

1959 • 12,895 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Methods in enzymology, vol. 127

1987 • 1,134 citations

Techniques of Lipidology

1972 • 1,090 citations

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.

1989 • 532 citations

Measurement of rates of cholesterol synthesis using tritiated water

1984 • 204 citations

Species variations in phospholipid class distribution of organs: I. Kidney, liver and spleen

1969 • 195 citations

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

1989 • 172 citations

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis

1974 • 161 citations

Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates.

1979 • 160 citations

Limitations of Acetate as a Substrate for Measuring Cholesterol Synthesis in Liver

1974 • 144 citations

Measurement of rate of rat liver sterol synthesis in vivo using tritiated water.

1977 • 114 citations

Purification and properties of a soluble protein activator of rat liver squalene epoxidase.

1977 • 91 citations

METABOLIC RELATIONSHIPS BETWEEN MYELIN SUBFRACTIONS: ENTRY OF GALACTOLIPIDS AND PHOSPHOLIPIDS ¹

1976 • 88 citations

Purification and properties of sterol carrier protein1.

1976 • 87 citations

Tellurium neuropathy

1970 • 75 citations

LIPID AND PROTEIN CHANGES IN SCIATIC NERVE DURING WALLERIAN DEGENERATION

1974 • 71 citations

Tellurium‐Induced Neuropathy: Metabolic Alterations Associated with Demyelination and Remyelination in Rat Sciatic Nerve

1989 • 67 citations

MYELIN SYNTHESIS IN VITRO: A COMPARATIVE STUDY OF CENTRAL AND PERIPHERAL NERVOUS TISSUE

1971 • 65 citations

Cholesterol from Degenerating Nerve Myelin Becomes Associated with Lipoproteins Containing Apolipoprotein E

1991 • 64 citations

Supernatant protein factor facilitates intermembrane transfer of squalene.

1980 • 63 citations

Effect of a supernatant protein on microsomal squalene epoxidase and 2,3-oxidosqualene-lanosterol cyclase.

1976 • 59 citations

Mechanism of demyelination in tellurium neuropathy. Electron microscopic observations.

1971 • 58 citations

A Survey of Neurological Mutant Mice. pp 99–109

1988 • 46 citations

Tellurium hydrocephalus: Distribution of tellurium-127m between maternal, fetal, and neonatal tissues of the rat

1968 • 45 citations

Tellurium‐induced neuropathy: A model for reversible reductions in myelin protein gene expression

1990 • 41 citations

TELLURIUM‐INDUCED NEUROPATHY: CORRELATIVE PHYSIOLOGICAL, MORPHOLOGICAL AND ELECTRON MICROPROBE STUDIES

1979 • 41 citations

Schwann Cell Vulnerability to Demyelination is Associated with Internodal Length in Tellurium Neuropathy

1988 • 39 citations

Modified Bartlett assay for microscale lipid phosphorus analysis

1986 • 35 citations

Proliferation of schwann cells in tellurium-induced demyelination in young rats

1981 • 31 citations

Metabolism of Phosphate and Sulfate Groups Modifying the P₀ Protein of Peripheral Nervous System Myelin

1987 • 28 citations

[14C]Acetate metabolism in the peripheral nervous system

1983 • 26 citations

Tellurium‐induced myelinopathy in adult rats

1981 • 26 citations

Lipid Droplets in Schwann Cells During Tellurium Neuropathy Are Derived from Newly Synthesized Lipid

1990 • 25 citations

Tellurium‐Induced Alterations in 3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase Gene Expression and Enzyme Activity: Differential Effects in Sciatic Nerve and Liver Suggest Tissue‐Specific Regulation of Cholesterol Synthesis

1991 • 21 citations

Apolipoprotein E is Released by Rat Sciatic Nerve During Segmental Demyelination and Remyelination

1987 • 20 citations

Regulation of sterol synthesis and of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by lipoproteins in glial cells in primary culture

1987 • 15 citations

Experimental study on segmental demyelination in tellurium neuropathy.

1981 • 14 citations

Sciatic nerve contains alkanes; comparison between normal mice and neurological mutants‐Jimpy, Quaking and Trembler

1978 • 13 citations

Temporal relationship of blood-nerve barrier breakdown to the metabolic and morphologic alterations of tellurium neuropathy.

1989 • 12 citations

In Vitro Studies of Oligodendroglial Lipid Metabolism

1984 • 11 citations

A possible regulatory role of squalene epoxidase in chinese hamster ovary cells

1984 • 10 citations

Chapter 8 Cellular regulation of cholesterol metabolism

1987 • 8 citations