THE EFFECTS OF (+)‐ AND (–)‐PROPRANOLOL ON ³H‐TRANSMITTER EFFLUX IN GUINEA‐PIG ATRIA AND THE PRESYNAPTIC β‐ADRENOCEPTOR HYPOTHESIS

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977

1977 • 935 citations

Local regulation of adrenergic neurotransmission.

1977 • 645 citations

PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE.

1977 • 616 citations

The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias

1968 • 562 citations

Cerebral arterial spasm

1974 • 390 citations

POSSIBLE ROLE OF A β‐ADRENOCEPTOR IN THE REGULATION OF NORADRENALINE RELEASE BY NERVE STIMULATION THROUGH A POSITIVE FEED‐BACK MECHANISM

1975 • 334 citations

Dibenamine blockade in strips of rabbit aorta and its use in differentiating receptors.

1954 • 165 citations

Presynaptic receptor systems on the noradrenergic neurones of the rabbit pulmonary artery

1977 • 165 citations

β₂‐Adrenoceptors Facilitating Noradrenaline Secretion from Human Vasoconstrictor Nerves

1976 • 158 citations

Different types of sympathomimetic α-receptors

1965 • 129 citations

The effect of a saturable uptake mechanism on the slopes of dose-response curves for sympathomimetic amines and on the shifts of dose-response curves produced by a competitive antagonist.

1969 • 127 citations

Mode of action of beta receptor antagonists on cardiac muscle

1966 • 121 citations

AN ANALYSIS OF THE RESPONSES OF THE ISOLATED PORTAL VEIN OF THE RABBIT TO ELECTRICAL STIMULATION AND TO DRUGS

1967 • 113 citations

Adrenergic receptors in the veins of the dog

1969 • 110 citations

Selective blockade of potassium-induced contractions of aortic strips by beta-diethylaminoethyl-diphenylpropylacetate (SKF 525A).

1970 • 57 citations

SINGLE PULSE STIMULATION OF GUINEA‐PIG VAS DEFERENS AND THE PRESYNAPTIC RECEPTOR HYPOTHESIS

1979 • 57 citations

STIMULATION OF PRESYNAPTIC β‐ADRENOCEPTORS ENHANCES [³H]‐N0RADRENALINE RELEASE DURING NERVE STIMULATION IN THE PERFUSED CAT SPLEEN

1978 • 57 citations

Role of adrenergic neurone blockade in the hypotensive action of propranolol

1971 • 54 citations

Selectivity for catecholamines of presynaptic alpha-receptors involved in feedback control of sympathetic neurotransmitter secretion in guinea-pig vas deferens

1975 • 52 citations

Effects of inhibition of monoamine oxidase on the actions and interactions of norepinephrine, tyramine and other drugs on guinea-pig left atrium.

1968 • 51 citations

Adrenergic antagonists and the presynaptic receptor hypothesis in vascular tissue.

1979 • 51 citations

Adrenergic neuron blocking properties of (±)-propranolol and (+)-propranolol

1970 • 50 citations

Influence of α- and β-adrenoceptors on the release of noradrenaline from field stimulated atria and cerebral cortex slices

1974 • 47 citations

The bimodal basis of the contractile response of the rabbit ear artery to norepinephrine and other agonists

1973 • 44 citations

The sensitivity of the guinea-pig pacemaker to norepinephrine and calcium after pretreatment with reserpine.

1968 • 43 citations

Limitations of presynaptic adrenoceptor theory: the characteristics of the effects of noradrenaline and phenoxybenzamine on stimulation-induced efflux of [3H]noradrenaline in vas deferens.

1980 • 42 citations

The Role of α- and β-Presynaptic Receptors in the Regulation of Noradrenaline Release Elicited by Nerve Stimulation

1976 • 41 citations

A receptor kinetic model of a vascular neuroeffector.

1972 • 35 citations

Dissociation of the supersensitivity to norepinephrine caused by cocaine from inhibition of H3-norepinephrine uptake in cold-stored smooth muscle.

1969 • 34 citations

Further studies on the adrenergic neuron blocking activity of some β-adrenoceptor antagonists and guanethidine

1973 • 33 citations

AN EXAMINATION OF THE NEGATIVE FEEDBACK FUNCTION OF PRESYNAPTIC ADRENOCEPTORS IN A VASCULAR TISSUE

1979 • 33 citations

Decrease in ionic permeability of the cell membrane in guinea‐pig atrial tissue by treatment with antifibrillatory agents and hexobarbitone, determined by means of ⁸⁶Rb

1969 • 28 citations

Mechanism of methylxanthine sensitization of norepinephrine responses in a coronaryartery

1975 • 27 citations

Anti‐arrhythmic, local anaesthetic, and adrenergic blocking activity of some β‐receptor antagonists

1969 • 26 citations

The presence of antagonistically acting alpha and beta adrenergic receptors in the mouse spleen.

1968 • 24 citations

Beta-receptors in human isolated smooth muscle.

1969 • 23 citations

Interactions of bretylium and other drugs on guinea-pig atria: evidence for inhibition of neuronal monoamine oxidase by bretylium.

1971 • 23 citations

EFFECTS OF COCAINE ON THE RATE OF CONTRACTION TO NORADRENALINE IN THE CAT SPLEEN STRIP: MODE OF ACTION OF COCAINE

1968 • 22 citations

Adrenergic presynaptic receptors: Examination of a hypothesis in guinea pig vas deferens

1979 • 20 citations

The potentiation of rat uterine inhibitory responses to noradrenaline by theophylline and nitroglycerine

1968 • 19 citations

Adrenergic Receptors in the Guinea Pig Trachea and Lung

1969 • 16 citations

The slopes of cumulative and non-cumulative dose-response curves for nonadrenaline and isoprenaline

1972 • 11 citations

Noradrenaline inhibition of transmitter efflux in a renal artery preparation and the presynaptic receptor theory

1979 • 8 citations

Blockade of catecholamine mediated release of free fatty acids from adipose tissue in vitro.

1967 • 7 citations

MECHANISMS OF INACTIVATION OF NORADRENALINE IN THE IRIS SPHINCTER, TRACHEAL MUSCLE AND FACIAL ARTERY OF CATTLE: IMPLICATIONS FOR β‐ADRENOCEPTOR‐MEDIATED RESPONSES

1978 • 4 citations