Ligand-Selective Activation of μ-Opioid Receptor: Demonstrated with Deletion and Single Amino Acid Mutations of Third Intracellular Loop Domain

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

1990 • 600 citations

Molecular Basis of Receptor/G-Protein-Coupling Selectivity

1998 • 444 citations

Drug Efficacy at G Protein–Coupled Receptors

2002 • 315 citations

Phosphorylation and Agonist‐Specific Intracellular Trafficking of an Epitope‐Tagged μ‐Opioid Receptor Expressed in HEK 293 Cells

1995 • 291 citations

-mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity.

1994 • 236 citations

Regulation of opioid receptor activities.

1999 • 202 citations

Differential μ Opiate Receptor Phosphorylation and Desensitization Induced by Agonists and Phorbol Esters

1996 • 162 citations

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.

1991 • 131 citations

Calmodulin Binding to G Protein-coupling Domain of Opioid Receptors

1999 • 128 citations

μ-Opioid Receptor-mediated ERK Activation Involves Calmodulin-dependent Epidermal Growth Factor Receptor Transactivation

2001 • 123 citations

Structure and function of proteins in G-protein-coupled signal transfer

1996 • 123 citations

Receptor Density and Recycling Affect the Rate of Agonist-Induced Desensitization of μ-Opioid Receptor

2000 • 108 citations

Identification of a Ligand-dependent Switch within a Muscarinic Receptor

1998 • 88 citations

Hierarchical Phosphorylation of δ-Opioid Receptor Regulates Agonist-induced Receptor Desensitization and Internalization

2000 • 87 citations

Molecular Mechanisms Involved in Muscarinic Acetylcholine Receptor-mediated G Protein Activation Studied by Insertion Mutagenesis

1996 • 77 citations

Constitutive Activation of the δ Opioid Receptor by Mutations in Transmembrane Domains III and VII

1999 • 73 citations

The μ-Opioid Receptor Down-Regulates Differently from the δ-Opioid Receptor: Requirement of a High Affinity Receptor/G Protein Complex Formation

1997 • 72 citations

Mutational analysis of the structure and function of opioid receptors

1999 • 71 citations

Single Nucleotide Polymorphisms in the Human μ Opioid Receptor Gene Alter Basal G Protein Coupling and Calmodulin Binding

2001 • 71 citations

Involvement of specific hydrophobic, but not hydrophilic, amino acids in the third intracellular loop of the beta-adrenergic receptor in the activation of Gs.

1992 • 68 citations

Distinct Differences Between Morphine‐ and [<scp>d</scp>‐Ala²,N‐MePhe⁴,Gly‐ol⁵]‐Enkephalin‐ μ‐Opioid Receptor Complexes Demonstrated by Cyclic AMP‐Dependent Protein Kinase Phosphorylation

1998 • 67 citations

Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase.

1993 • 59 citations

Constitutively Active μ-Opioid Receptors Inhibit Adenylyl Cyclase Activity in Intact Cells and Activate G-proteins Differently than the Agonist [d-Ala2,N-MePhe4,Gly-ol5]Enkephalin

2001 • 51 citations

Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides.

1996 • 47 citations

Nuclear Ca²⁺/Calmodulin Translocation Activated by μ‐Opioid(OP₃) Receptor

2000 • 42 citations

Selective interactions of μ-opioid receptors with pertussis toxin-sensitive G proteins: involvement of the third intracellular loop and the c-terminal tail in coupling

1997 • 41 citations

Identification of the amino acid residues involved in selective agonist binding in the first extracellular loop of the δ‐ and μ‐opioid receptors

1995 • 40 citations

Mutations of Two Adjacent Amino Acids Generate Inactive and Constitutively Active Forms of the Human Platelet-activating Factor Receptor

1996 • 34 citations

Altered adenylyl cyclase responsiveness subsequent to point mutations of Asp 128 in the third transmembrane domain of the δ-opioid receptor

1999 • 16 citations

Effects of C‐Terminal Truncation of the Recombinant δ‐Opioid Receptor on Phospholipase C and Adenylyl Cyclase Coupling

1998 • 15 citations

μ Opiate receptor

1998 • 13 citations