Phosphatidylinositol specific phospholipases C

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Hormonal effects on calcium homeostasis in isolated hepatocytes.

1980 • 441 citations

Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines

1980 • 298 citations

Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.

1980 • 287 citations

Inositol phospholipids in membrane function

1979 • 272 citations

Role of phosphatidylinositol in attachment of alkaline phosphatase to membranes

1980 • 256 citations

Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus. I. purification, properties and phosphatase-releasing activity.

1976 • 252 citations

Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C.

1977 • 217 citations

Studies on alpha-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in alpha-adrenergic activation of phosphorylase in perfused rat liver.

1979 • 201 citations

Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus

1976 • 200 citations

Specific release of plasma membrane enzymes by a phosphatidylinositol-specific phospholipase C

1978 • 196 citations

Non‐lytic release of acetylcholinesterase from erythrocytes by A phosphatidylinositol‐specific phospholipase C

1977 • 195 citations

Purification of phosphatidylinositol-specific phospholipase C from rat liver.

1981 • 180 citations

The enzymic formation of myoinositol 1:2-cyclic phosphate from phosphatidylinositol

1971 • 177 citations

Phosphatidylinositol-specific phospholipase-C of platelets: Association with 1,2-diacylglycerol-kinase and inhibition by cyclic-AMP

1979 • 161 citations

Recent hypotheses regarding the phosphatidylinositol effect

1981 • 156 citations

Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin

1981 • 152 citations

A membrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, <scp>d</scp>-myoinositol 1:2-cyclic phosphate and <scp>d</scp>-myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex

1973 • 141 citations

Phosphoinositides. 3. Enzymic hydrolysis of inositol-containing phospholipids

1961 • 137 citations

Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol

1979 • 129 citations

Evidence for mitochondrial localization of the hormone-responsive pool of Ca2+ in isolated hepatocytes.

1979 • 128 citations

<scp>d</scp>-myoInositol 1:2-cyclic phosphate 2-phosphohydrolase

1972 • 128 citations

Indomethacin-induced accumulation of diglyceride in activated human platelets. The role of diglyceride lipase.

1980 • 122 citations

[85] Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus

1981 • 118 citations

Enzymatic properties of phosphatidylinositol inositolphosphohydrolase from Bacillus cereus. Substrate dilution in detergent-phospholipid micelles and bilayer vesicles.

1978 • 115 citations

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase

1979 • 110 citations

The dependence on Ca2+ of phosphatidylinositol breakdown and enzyme secretion in rabbit neutrophils stimulated by formylmethionyl-leucylphenylalanine or ionomycin

1981 • 109 citations

Purification and properties of phosphatidylinositol-specific phospholipase C of Bacillus thuringiensis

1980 • 108 citations

Characterization of the Phospholipases of Bacillus cereus and Their Effects on Erythrocytes, Bone, and Kidney Cells

1965 • 108 citations

Control by TSH of a phospholipase A₂ activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid

1973 • 108 citations

The activation of phosphatidylinositol-hydrolyzing phospholipase A2 during prostaglandin synthesis in transformed mouse BALB/3T3 cells.

1981 • 104 citations

Phosphatidyl inositol-specific phospholipase C from Clostridium novyi type A

1978 • 102 citations

Studies on the enzymic hydrolysis of monophosphoinositide by phospholipase preparations from P. notatum and ox pancreas

1959 • 102 citations

The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain

1978 • 99 citations

Role of negatively charged phospholipids in highly purified (Na+ + K+)-ATPase from rabbit kidney outer medulla. Studies on (Na+ + K+)-activated ATPase, XXXIX

1978 • 98 citations

Stimulus–secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown

1980 • 97 citations

Myo-inositol Lipids

1976 • 94 citations

The Phosphoinositide Inositolphosphohydrolase of Guinea‐Pig Intestinal Mucosa

1968 • 92 citations

The Calcium‐Dependent Phosphatidylinositol‐Phosphodiesterase of Rat Brain

1979 • 92 citations

THE DISTRIBUTION OF CALCIUM‐DEPENDENT PHOSPHATIDYLINOSITOL‐SPECIFIC PHOSPHODIESTERASE IN RAT BRAIN

1978 • 90 citations

Two phospholipase pools for prostaglandin synthesis in macrophages

1981 • 89 citations

Calcium and the Muscarinic Synaptosomal Phospholipid Labeling Effect

1980 • 86 citations

Metabolism of phospholipids by spermatozoa and seminal plasma

1968 • 86 citations

Stimulus-Response Coupling at α-Adrenergic Receptors

1978 • 78 citations

Phosphatidylinositol cleavage in lymphocytes. Requirement for calcium ions at a low concentration and effects of other cations

1974 • 77 citations

THE HYDROLYSIS OF MONOPHOSPHOINOSITIDE BY EXTRACTS OF BRAIN

1967 • 74 citations

Selective release of plasma-membrane enzymes from rat hepatocytes by a phosphatidylinositol-specific phospholipase C

1980 • 73 citations

The hydrolysis of phosphatidylinositol monolayers at an air/water interface by the calcium-ion-dependent phosphatidylinositol phosphodiesterase of pig brain

1981 • 71 citations

Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0

1974 • 70 citations

The hydrolysis of triphosphoinositide by extracts of ox brain

1964 • 69 citations

Phosphatidylinositol-specific Phospholipase C in Fetal Membranes and Uterine Decidua

1981 • 66 citations

Direct demonstration of the formation of prostaglandin E2 due to phosphatidylinositol breakdown associated with stimulation of enzyme secretion in the pancreas.

1981 • 65 citations

A calcium requirement for the phosphatidylinositol response following activation of presynaptic muscarinic receptors

1979 • 63 citations

Metabolism and Role of Phosphatidylinositol in Acetylcholinestimulated Membrane Function

1977 • 61 citations

Modification of erythrocyte membranes by a purified phosphatidylinositol-specific phospholipase C (Staphylococcus aureus)

1977 • 61 citations

Phosphatidylinositol phosphodiesterase in higher plants

1980 • 58 citations

f‐MetLeuPhe‐induced phosphatidylinositol turnover in rabbit neutrophils is dependent on extracellular calcium

1980 • 57 citations

Ca2+-dependent and Ca2+-independent degradation of phosphatidylinositol in rabbit vas deferens

1981 • 52 citations

Evidence that phosphatidic acid stimulates the uptake of calcium by liver cells but not calcium release from mitochondria

1981 • 52 citations

The Inhibition and Activation of Ca²⁺‐Dependent Phosphatidylinositol Phosphodiesterase by Phospholipids and Blood Plasma

1980 • 51 citations

Phospholipases as probes for membrane sideness. Selective analysis of the outer monolayer of asymmetric bilayer vesicles

1978 • 50 citations

The association between phosphatidylinositol phosphodiesterase activity and a specific subunit of microtubular protein in rat brain

1973 • 48 citations

The action of phosphatidylinositol-specific phospholipases C on membranes

1976 • 47 citations

Phosphatidylinositol-degrading enzymes in liver lysosomes

1977 • 47 citations

Studies on the properties of a soluble phosphatidylinositol-phosphodiesterase of rabbit iris smooth muscle

1980 • 42 citations

Effect of the α-agonist noradrenaline on total and 45Ca2+ movements in mitochondria of rat liver cells

1981 • 41 citations

THE ENZYMIC HYDROLYSIS OF PHOSPHATIDYL INOSITOL BY GUINEA PIG BRAIN:

1969 • 41 citations

Vasopressin and epinephrine stimulation of phosphatidylinositol breakdown in the plasma membrane of rat hepatocytes

1981 • 41 citations

Cerebral diphosphoinositide breakdown: activation, complexity and distribution in animal (mainly nervous) tissues

1956 • 40 citations

THE SUBCELLULAR LOCALIZATION OF CARBAMYLCHOLINE‐STIMULATED PHOSPHATIDYL INOSITOL TURNOVER IN RAT CEREBRAL CORTEX IN VIVO

1975 • 35 citations

Effects of Polyamines on Calcium‐Dependent Rat Brain Phosphatidylinositol‐Phosphodiesterase

1981 • 33 citations

Studies on phosphatidylinositol phosphodiesterase (phospholipase C type) of Bacillus cereus

1978 • 32 citations

Evidence for functionally distinct pools of phospholipase responsible for prostaglandin release from the perfused guinea-pig lung

1980 • 32 citations

THE EFFECTS OF SECRETAGOGUES ON THE INCORPORATION OF [2-3H]MYOINOSITOL INTO LIPID IN CYTOLOGICAL FRACTIONS IN THE PANCREAS OF THE GUINEA PIG IN VIVO

1973 • 31 citations

The fraction of phosphatidylinositol that activates the (Na+ + K+)-ATPase in rabbit kidney microsomes is closely associated with the enzyme protein

1981 • 31 citations

Subcellular Localization of the Alterations in Phosphatidylinositol Metabolism Following Glucose-induced Insulin Release from Rat Pancreatic Islets

1977 • 28 citations

Lipid dependence of glucose-6-phosphate phosphohydrolase: a study with purified phospholipid transfer proteins and phosphatidylinositol-specific phospholipase C

1981 • 26 citations

Role of phosphatidylinositol in basal adenylate cyclase activity of rat heart sarcolemma

1981 • 23 citations

Solubilization of rat heart sarcolemma 5′-nucleotidase by phosphatidylinositol-specific phospholipase C

1981 • 20 citations

Evidence Against Dopaminergic and Further Support For α‐Adrenergic Receptor Involvement in the Pineal Pho sphatidy lino sitol Effect

1980 • 20 citations

Differences in the pattern of attack of acidic, neutral, and basic phospholipases A2 of A. halys blomhofii on human erythrocyte membranes: Problems in interpretation of phospholipid location

1981 • 17 citations

Phosphatidylinositol-degrading Enzymes in the Cellular Slime Mould Dictyostelium discoideum

1980 • 13 citations

Thyrotropin‐stimulated phosphatidylinositol‐specific phospholipase A₂ in pig thyroid, a re‐examination

1980 • 13 citations

Some transport properties of resealed washed human erythrocyte membranes

1978 • 12 citations

Subcellular localization of the alterations in phosphatidylinositol metabolism following glucose-induced insulin release from rat pancreatic islets

1977 • 9 citations

Phosphatidylinositol inositolphosphohydrolase activity in mammary tissue

1977 • 7 citations

Enzymes linked to phosphatidylinositol in plasma membranes

1980 • 4 citations