Review of the genotoxic properties of chlorpromazine and related phenothiazines

The Extra Pharmacopoeia

2018 • 1,742 citations

Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals

1986 • 771 citations

Detection of chemical mutagens by the dominant lethal assay in the mouse

1972 • 572 citations

Sister-chromatid exchanges: A report of the GENE-TOX program

1981 • 557 citations

Chemical mutagenesis testing in drosophila. IV. Results of 45 coded compounds tested for the national toxicology program

1985 • 318 citations

Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test

1984 • 211 citations

A new Salmonella tester strain, TA97, for the detection of frameshift mutagens

1982 • 197 citations

Sister-chromatid exchange: second report of the Gene-Tox program

1993 • 178 citations

Evaluation of the carcinogenic risk of chemicals to humans

1979 • 159 citations

Nitrosation and mutagenicity of some amine drugs

1980 • 96 citations

Screening of antioxidants and other compounds for antimutagenic properties towards benzo[a]pyrene-induced mutagenicity in strain TA98 of Salmonella typhimurium

1982 • 76 citations

In Vitro Studies on Longwave Ultraviolet Light-Dependent Reactions of the Skin Photosensitizer Chlorpromazine with Nucleic Acids, Purines and Pyrimidines

1970 • 70 citations

Formation of Active Metabolites of Psychotropic Drugs

1990 • 63 citations

Cytogenetic Effects of Tranquilizing Drugs in Vivo and in Vitro

1969 • 60 citations

Photomutagenesis test development: I. 8-methoxypsoralen, chlorpromazine and sunscreen compounds in bacterial and yeast assays

1993 • 58 citations

Chromosomal Aberrations in Users of Psychoactive Drugs

1971 • 52 citations

Chromosome Abnormalities in Patients Treated with Chlorpromazine, Perphenazine, and Lysergide

1969 • 52 citations

The present lack of evidence for unique rodent germ-cell mutagens

1989 • 51 citations

Photodynamic action of chlorpromazine on adenovirus 5: Repairable damage and single strand breaks

1977 • 49 citations

Development of assays for the detection of photomutagenicity of chemicals during exposure to UV light—I. Assay development

1991 • 45 citations

Chlorpromazine-induced damage on nucleic acids: a combined cytogenetic and biochemical study

1992 • 44 citations

ENHANCEMENT OF UV‐INDUCED SKIN CARCINOGENESIS BY AZATHIOPRINE: ROLE OF PHOTOCHEMICAL SENSITISATION

1989 • 43 citations

Structure-activity relationships of tricyclic antidepressants and related compounds in the wing somatic mutation and recombination test of Drosophila melanogaster

1993 • 40 citations

Antioxidants and the mutagenicity of benzo(a) pyrene and some derivatives

1978 • 39 citations

Photoactivation of chlorpromazine: cytogenetic and mutagenic effects.

1973 • 35 citations

Formation of DNA‐damaging nitroso compounds by interaction of drugs with nitrite. A preliminary screening for detecting potentially hazardous drugs

1985 • 35 citations

Photosensitive cataractogens, chlorpromazine and methoxypsoralen, cause DNA repair synthesis in lens epithelial cells.

1978 • 33 citations

In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine

1970 • 33 citations

Verapamil as a co-mutagen in the Salmonella/mammalian microsome mutagenicity test

1988 • 33 citations

Psychotropic drugs: Evaluation of mutagenic effect

1980 • 33 citations

pH dependence of the phototoxic and photomutagenic effects of chlorpromazine

1980 • 32 citations

Photoactivation of chlorpromazine: Cytogenetic and mutagenic effects

1973 • 31 citations

Photomutagenesis test development: II. 8-methoxypsoralen, chlorpromazine and sunscreen compounds in chromosomal aberration assays using CHO cells

1993 • 31 citations

Photomutagenicity assays in bacteria: factors affecting assay design and assessment of photomutagenic potential of para-aminobenzoic acid

1994 • 28 citations

The effect on sister-chromatid exchanges of drugs and dyes by intercalation and photoactivation

1979 • 27 citations

PHOTOADDITION OF CHLORPROMAZINE TO GUANOSINE‐5′‐MONOPHOSPHATE

1986 • 27 citations

The Emotional Vitamins--Paediatric Strength

1974 • 22 citations

Mutagenesis by Photoactivation of Chlorpromazine, a Tranquilizer of the Phenothiazine Group

1974 • 22 citations

Detection of chemical mutagens use of concentration gradient plates in a high capacity screen.

1977 • 21 citations

Enhancement of cytogenetic damage by chloropromazine in human lymphocytes treated with alkylating antineoplastics and caffeine

1988 • 21 citations

CHLORPROMAZINE PHOTOSENSITIZATION–II. FAILURE TO DETECT ANY EVIDENCE FOR INVOLVEMENT OF DNA DAMAGE IN THE PHOTODYNAMIC KILLING OF ESCHERICHIA COLI IN THE PRESENCE OF CHLORPROMAZINE

1980 • 19 citations

Increased growth inhibition and DNA lesions in human colon adenocarcinoma cells treated with methotrexate or 5-fluorodeoxyuridine followed by calmodulin inhibitors.

1988 • 18 citations

Evaluation of the micronucleus procedure over a 2-year period

1978 • 18 citations

Dominant lethal effects of triflupromazine in hybrid C3D2F1/J mice

1973 • 18 citations

In-vivo Cytogenetic Effects of Perphenazine and Chlorpromazine: A Negative Study

1972 • 17 citations

Induction of repairable DNA damage in Escherichia coli and interaction with DNA in vitro by the radical cation of chlorpromazine

1983 • 17 citations

Formation of nitroso compounds and mutagens from transquilizers by drug/nitrite interaction

1981 • 16 citations

Phototoxicity of phenothiazine derivatives. I. Inactivating and mutagenic effects on bacteriophage φX174

1983 • 16 citations

The effect of chlorpromazine on SCE frequency in human chromosomes

1982 • 15 citations

A study of triflupromazine in dominant-lethal, cytogenetic and host-mediated assays

1973 • 15 citations

The effect of substituted phenothiazines on the mutagenicity of benzo[a]pyrene

1981 • 13 citations

Effects of fluphenazine hydrochloride on the bonemarrow cells of swiss mice

1981 • 13 citations

Hazard identification: efficiency of short-term tests in identifying germ cell mutagens and putative nongenotoxic carcinogens.

1993 • 13 citations

Intercalating substances do not induce sister-chromatid exchanges (SCEs) in vivo

1982 • 13 citations

Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro

1980 • 12 citations

ChemInform Abstract: A Comprehensive Photochemical and Photophysical Assay Exploring the Photoreactivity of Drugs.

1989 • 12 citations

Inhibition of the mutagenicity and metabolism of 6-methyl-benzo[a]pyrene and 6-hydroxymethyl-benzo[a]pyrene

1986 • 10 citations

Chlorpromazine protection against acridine-induced reversion of a histidine-requiring mutant of Salmonella typhimurium

1974 • 10 citations

Termini generated at the site of the DNA breakage mediated by photoexcited promazines

1986 • 10 citations

The mutagenic activity of chlorpromazine

1988 • 9 citations

Cytogenetic effects of trifluoperazine in mice

1987 • 8 citations

Rat and human chromosome studies after promazine medication.

1969 • 8 citations

Investigation, with the Salmonella/microsome test, of psychopharmaceuticals used in meat production

1982 • 8 citations

Lack of DNA fragmentation in rats treated with high oral doses of drugs acting on the central nervous system.

1986 • 6 citations

Chlorpromazine reduces UV-induced squamous cell carcinogenesis in hairless mice and enhances UV-induced DNA damage in cultured cells

1989 • 6 citations

Mutagenicity evaluation of thioridazine

1983 • 6 citations

The effects of some drugs of the phenothiazide group on human chromosomes in vitro.

1975 • 4 citations

Clastogenic effect of the psychotropic drug thioridazine on human chromosomes in vivo

1982 • 3 citations

Investigation of the mutagenic activity of phenothiazines and other drug preparations.

1973 • 3 citations

Mutagenesis by heterocyclic aromatic compounds in Escherichia coli K12 strains of differing repair capacities

1983 • 2 citations

Photodynamic action of chlorpromazine on adenovirus-5: repairable damage and single-strand breaks

1977 • 2 citations

[Chromosome abnormalities in patients treated with chlorpromazine and perphenazine].

1971 • 1 citations

Effects of chlorpromazine on the structure of nucleic acids and cytogenetic studies in combination with adriamycin in Ehrlich ascites cells in vivo and/or with caffeine in human lymphocytes in vitro

1990 • 1 citations