New selective COMT inhibitors: useful adjuncts for Parkinson's disease?

[The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia].

1961 • 515 citations

Pharmacokinetics of Levodopa

1984 • 347 citations

“On‐off” phenomenon with levodopa therapy in parkinsonism

1974 • 232 citations

Clinical Pharmacokinetics of Anti-Parkinsonian Drugs

1987 • 181 citations

3-0-Methyldopa uptake and inhibition of L-dopa at the blood-brain barrier

1975 • 140 citations

Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat

1988 • 114 citations

Catechol-O-methyltransferase activity: A determinant of levodopa response

1980 • 114 citations

3‐O‐Methyldopa and the response to levodopa in Parkinson's disease

1987 • 94 citations

3‐O‐ methyldopa blocks dopa metabolism in rat corpus striatum

1982 • 81 citations

Effects of 3‐OM‐dopa on monoarnine metabolism in rat brain

1983 • 78 citations

Catechol-O-methyltransferase activity in human and rat small intestine

1988 • 72 citations

The Clinical Picture and Plasma Levodopa Metabolite Profile of Parkinsonian Nonresponders

1977 • 64 citations

The metabolism of L‐3–0‐methyldopa, aprecursor of dopa in man

1971 • 63 citations

Potentiation of the l-Dopa effect in man by the use of catechol-O-methyltransferase inhibitors

1971 • 62 citations

Properties of novel effective and highly selective inhibitors of catechol-O-methyltransferase

1988 • 58 citations

3‐O‐Methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway

1982 • 49 citations

Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease.

1988 • 47 citations

DOES O-METHYL-DOPA PLAY A ROLE IN LEVODOPA-INDUCED DYSKINESIAS?

2009 • 40 citations

Parkinsonism treated with 3-0-methyldopa

1973 • 36 citations

Catechol-O-methyltransferase and Parkinson's disease.

1984 • 33 citations

Pharmacokinetics of L-dopa in patients with Parkinson's disease.

1987 • 31 citations

Clinical significance of the relationship between O‐methyldopa levels and levodopa intake

1988 • 29 citations

Effect of chronic administration of L-dopa on catechol-O-methyltransferase in rat tissues

1973 • 26 citations