Neuroprotective activity of acetyl‐L‐carnitine: Studies in vitro

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Carnitine and Its Role in Fatty Acid Metabolism* *Work reviewed from this laboratory was supported by grants A-1465 and A-1682 from the National Institutes of Health.

1963 • 446 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

Glutamate dysfunction in Alzheimer's disease: an hypothesis

1987 • 335 citations

Neocortical Metabolic Abnormalities Precede Nonmemory Cognitive Defects in Early Alzheimer's-Type Dementia

1986 • 274 citations

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

1992 • 250 citations

Long‐term acetyl‐L‐carnitine treatment in Alzheimer's disease

1991 • 233 citations

Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations

1992 • 225 citations

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

1985 • 164 citations

Neurotoxicity at the N‐Methyl‐D‐Aspartate Receptor in Energy‐Compromised Neurons An Hypothesis for Cell Death in Aging and Disease

1989 • 157 citations

Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine.

1992 • 136 citations

Ammonium Injection Induces an N‐Methyl‐<scp>d</scp>‐Aspartate Receptor‐Mediated Proteolysis of the Microtubule‐Associated Protein MAP‐2

1993 • 72 citations

Acetyl-l-carnitine enhances the response of PC12 cells to nerve growth factor

1991 • 70 citations

Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine

1965 • 69 citations

Effect of acetyl-l-carnitine chronic treatment on discrimination models in aged rats

1988 • 63 citations

Culture of dorsal root ganglion neurons from aged rats: Effects of acetyl‐<scp>l</scp>‐carnitine and NGF

1992 • 51 citations

Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine

1992 • 40 citations

Carnitine acetyltransferase activity in the human brain and its microvessels is decreased in Alzheimer's disease

1992 • 34 citations

L-Acetylcarnitine in the Treatment of Patients with Peripheral Neuropathies

1995 • 32 citations

Effects of N‐Methyl‐d‐Aspartate on [Ca²⁺]_i and the Energy State in the Brain by ¹⁹F‐ and ³¹P‐Nuclear Magnetic Resonance Spectroscopy

1990 • 26 citations

Acetyl-L-Carnitine in the Rat’s Hippocampus Aging: Morphological, Endocrine and Behavioral Correlates

1988 • 8 citations