Clinical judgement and therapeutic decision making

BMDP Statistical Software 1981.

1984 • 5,347 citations

Effects of Enalapril on Mortality in Severe Congestive Heart Failure

1987 • 4,763 citations

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

1988 • 3,818 citations

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

1985 • 3,610 citations

The MOS Short-form General Health Survey

1988 • 3,311 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial Infarction

1989 • 3,227 citations

The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

Statistical Methods for Survival Data Analysis.

1993 • 2,960 citations

急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2

1988 • 2,760 citations

Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

1988 • 2,740 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 2,673 citations

Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure

1986 • 2,409 citations

EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION

1986 • 2,315 citations

Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults

1988 • 2,276 citations

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

1987 • 2,245 citations

Expert and Novice Performance in Solving Physics Problems

1980 • 2,075 citations

Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin

1986 • 1,857 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Regression modelling strategies for improved prognostic prediction

1984 • 1,693 citations

Multiple Risk Factor Intervention Trial

1982 • 1,670 citations

Clinical decision analysis

2005 • 1,645 citations

The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial

1978 • 1,634 citations

A brief self-administered questionnaire to determine functional capacity (The Duke Activity Status Index)

1989 • 1,620 citations

MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

1985 • 1,463 citations

Clinical Decision Analysis

1980 • 1,417 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 1,373 citations

Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg

1967 • 1,318 citations

Aspirin, Heparin, or Both to Treat Acute Unstable Angina

1988 • 1,290 citations

A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction

1982 • 1,286 citations

Meta-Analyses of Randomized Controlled Trials

1987 • 1,278 citations

Effects Morbidity of Treatment on in Hypertension

1970 • 1,278 citations

Meta-Analysis in Clinical Research

1987 • 1,269 citations

Five-Year Findings of the Hypertension Detection and Follow-up Program

1979 • 1,212 citations

Coronary artery surgery study (CASS): a randomized trial of coronary artery bypass surgery. Survival data.

1983 • 1,177 citations

Aspirin, Sulfinpyrazone, or Both in Unstable Angina

1985 • 1,146 citations

The Cardiac Arrhythmia Suppression Trial Investigators: Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression After Myocardial Infarction.

1990 • 1,074 citations

Effects of Treatment on Morbidity in Hypertension

1967 • 1,068 citations

EFFECT OF DIET AND SMOKING INTERVENTION ON THE INCIDENCE OF CORONARY HEART DISEASE

1981 • 1,050 citations

Comparison of Invasive and Conservative Strategies after Treatment with Intravenous Tissue Plasminogen Activator in Acute Myocardial Infarction

1989 • 991 citations

Assessment of quality of life in clinical trials of cardiovascular therapies

1984 • 986 citations

A Randomized Trial of Immediate versus Delayed Elective Angioplasty after Intravenous Tissue Plasminogen Activator in Acute Myocardial Infarction

1987 • 964 citations

Secondary prevention of vascular disease by prolonged antiplatelet treatment

1988 • 962 citations

Cardiac rehabilitation after myocardial infarction. Combined experience of randomized clinical trials

1988 • 894 citations

Percutaneous Transluminal Coronary Angioplasty in 1985–1986 and 1977–1981

1988 • 859 citations

Results of coronary artery surgery in patients with poor left ventricular function (CASS).

1983 • 824 citations

Protocol-Based Computer Reminders, the Quality of Care and the Non-Perfectability of Man

1976 • 821 citations

The Effect of Diltiazem on Mortality and Reinfarction after Myocardial Infarction

1988 • 793 citations

Clinical Trials: Design, Conduct, and Analysis

1986 • 782 citations

Survival of medically treated patients in the coronary artery surgery study (CASS) registry.

1982 • 758 citations

Statistical Methods for Survival Data Analysis

1981 • 758 citations

RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1985 • 756 citations

Thrombolysis inMyocardial Infarction (TIMI) Trial, Phase I:acomparison between intravenous tissue plasminogen activator andintravenous streptokinase*

1987 • 751 citations

Cardiac Rehabilitation After Myocardial Infarction

1988 • 742 citations

Twelve-Year Follow-up of Survival in the Randomized European Coronary Surgery Study

1988 • 713 citations

Variables predictive of survival in patients with coronary disease. Selection by univariate and multivariate analyses from the clinical, electrocardiographic, exercise, arteriographic, and quantitative angiographic evaluations.

1979 • 678 citations

THROMBOLYSIS WITH TISSUE PLASMINOGEN ACTIVATOR IN ACUTE MYOCARDIAL INFARCTION: NO ADDITIONAL BENEFIT FROM IMMEDIATE PERCUTANEOUS CORONARY ANGIOPLASTY

1988 • 669 citations

Variations in the Use of Medical and Surgical Services by the Medicare Population

1986 • 659 citations

Does Inappropriate Use Explain Geographic Variations in the Use of Health Care Services?

1987 • 635 citations

Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials

1985 • 578 citations

Variations in Physician Practice: The Role of Uncertainty

1984 • 575 citations

Eleven-Year Survival in the Veterans Administration Randomized Trial of Coronary Bypass Surgery for Stable Angina

1984 • 573 citations

ARE HOSPITAL SERVICES RATIONED IN NEW HAVEN OR OVER-UTILISED IN BOSTON?

1987 • 537 citations

Using and Understanding Medical Statistics

1987 • 535 citations

The Australian therapeutic trial in mild hypertension.

1984 • 528 citations

The effect of diltiazem on mortality and reinfarction after myocardial infarction

1989 • 513 citations

The VA cooperative randomized study of surgery for coronary arterial occlusive disease II. Subgroup with significant left main lesions.

1976 • 509 citations

Preliminary Report: Findings from the Aspirin Component of the Ongoing Physicians' Health Study

1988 • 504 citations

Overview of Results of Randomized Clinical Trials in Heart Disease

1988 • 501 citations

Treatment of Chronic Stable Angina

1977 • 492 citations

Thrombolysis in myocardial infarction (TIMI) trial: Phase I. A comparison between intravenous tissue plasminogen activator and intravenous streptokinase

1988 • 475 citations

Persantine and aspirin in coronary heart disease. The Persantine-Aspirin Reinfarction Study Research Group.

1980 • 464 citations

A Randomized, Controlled Trial of Aspirin in Persons Recovered From Myocardial Infarction

1980 • 462 citations

Prognostic value of a coronary artery jeopardy score

1985 • 460 citations

Food and Drug Administration

2011 • 459 citations

Evidence Favoring the Use of Anticoagulants in the Hospital Phase of Acute Myocardial Infarction

1977 • 439 citations

Effect of coronary bypass surgery on survival patterns in subsets of patients with left main coronary artery disease

1981 • 427 citations

Coronary artery surgery study (CASS): a randomized trial of coronary artery bypass surgery. Quality of life in patients randomly assigned to treatment groups.

1983 • 427 citations

Five-Year Findings of the Hypertension Detection and Follow-up Program

1979 • 417 citations

Effectiveness in Health Care

1988 • 414 citations

Percutaneous transluminal coronary angioplasty: Report from the registry of the National Heart, Lung, and Blood Institute

1982 • 406 citations

Assessment of quality of life in clinical trials of cardiovascular therapies

1985 • 393 citations

EFFECT OF INTRAVENOUS NITRATES ON MORTALITY IN ACUTE MYOCARDIAL INFARCTION: AN OVERVIEW OF THE RANDOMISED TRIALS

1988 • 392 citations

Survival in medically treated coronary artery disease.

1979 • 388 citations

Myocardial Infarction and Mortality in the Coronary Artery Surgery Study (CASS) Randomized Trial

1984 • 365 citations

Estimating the likelihood of significant coronary artery disease

1983 • 360 citations

Immediate vs Delayed Catheterization and Angioplasty Following Thrombolytic Therapy for Acute Myocardial Infarction

1988 • 358 citations

The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: A review of randomized controlled trials

1986 • 342 citations

Secondary prevention after myocardial infarction: A review of long-term trials

1982 • 334 citations

The Effect of Treatment on Mortality in Mild Hypertension

1982 • 331 citations

Biostatistics in Clinical Medicine.

1988 • 329 citations

Unstable angina pectoris: National cooperative study group to compare surgical and medical therapy

1978 • 329 citations

Prognostic value of angiographic indices of coronary artery disease from the Coronary Artery Surgery Study (CASS).

1983 • 318 citations

Effects of Prophylactic Lidocaine in Suspected Acute Myocardial Infarction

1988 • 315 citations

The Evolution of Medical and Surgical Therapy for Coronary Artery Disease

1989 • 300 citations

Sex differences in early and long-term results of coronary angioplasty in the NHLBI PTCA Registry.

1985 • 283 citations

Survival in medically treated coronary artery disease.

1979 • 267 citations

Overview of results of randomized clinical trials in heart disease. II. Unstable angina, heart failure, primary prevention with aspirin, and risk factor modification

1988 • 267 citations

The prognostic spectrum of left main stenosis.

1978 • 266 citations

Artificial Intelligence in Medical Diagnosis

1988 • 252 citations

Meta-analysis. A quantitative approach to research integration

1988 • 242 citations

DOUBLE-BLIND RANDOMISED TRIAL OF INTRAVENOUS TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS PLACEBO IN ACUTE MYOCARDIAL INFARCTION

1985 • 242 citations

Treatment of mild hypertension: results of a ten-year intervention trial.

1977 • 242 citations

THE AUSTRALIAN THERAPEUTIC TRIAL IN MILD HYPERTENSION

1980 • 234 citations

Clinical Trials: Design, Conduct, and Analysis

1987 • 229 citations

Prognostic indicators from radionuclide angiography in medically treated patients with coronary artery disease

1984 • 227 citations

Five-Year Findings of the Hypertension Detection and Follow-up Program

1982 • 212 citations

Six- and twelve-month follow-up of the phase I thrombolysis in myocardial infarction (TIMI) trial

1988 • 209 citations

Effect of Intravenous Streptokinase on Acute Myocardial Infarction

1982 • 206 citations

Catheter ablation of the atrioventricular junction: a report of the percutaneous mapping and ablation registry.

1984 • 206 citations

Comparison of predictions based on observational data with the results of randomized controlled clinical trials of coronary artery bypass surgery

1988 • 185 citations

Overview of Results of Randomized Clinical Trials in Heart Disease

1988 • 182 citations

Comparison of Coronary Artery Bypass Surgery and Medical Therapy in Patients 65 Years of Age or Older

1985 • 172 citations

Importance of clinical measures of ischemia in the prognosis of patients with documented coronary artery disease

1988 • 166 citations

Outcome in medically treated coronary artery disease. Ischemic events: nonfatal infarction and death.

1980 • 159 citations

Predicting outcome in coronary disease statistical models versus expert clinicians

1986 • 142 citations

Meta-analysis

1988 • 141 citations

Effect of propranolol in postinfarction patients with mechanical or electrical complications.

1984 • 140 citations

Treatment of mild hypertension: results of a ten-year intervention trial.

1977 • 137 citations

Unstable angina pectoris: National cooperative study group to compare medical and surgical therapy

1981 • 137 citations

Anticoagulants and Myocardial Infarction

1979 • 128 citations

Disturbed by Meta-Analysis?

1988 • 124 citations

A Randomized Trial of Propranolol in Patients With Acute Myocardial Infarction

1983 • 122 citations

The Veterans Administration Cooperative Study of stable angina: current status.

1982 • 118 citations

Prediction of risk of anterior myocardial infarction by lesion severity and measurement method of stenoses in the left anterior descending coronary distribution: A CASS registry study

1988 • 114 citations

Doctors' Decisions and the Cost of Medical Care: The Reasons for Doctors' Practice Patterns and Ways to Change Them

1986 • 111 citations

How Decisions are Reached: Physician and Patient

1982 • 109 citations

Outcome in one-vessel coronary artery disease.

1983 • 104 citations

Unstable angina pectoris: National cooperative study group to compare medical and surgical therapy

1976 • 103 citations

Assessing data quality: A computerized approach

1989 • 96 citations

Resolving conflicting clinical trials: Guidelines for meta-analysis

1988 • 93 citations

Survival following coronary artery bypass grafting in patients with severe angina pectoris (CASS)

1985 • 91 citations

Clinical Data Bases

1985 • 87 citations

Long-term (5 year) results of coronary bypass surgery in patients 65 years old or older: a report from the Coronary Artery Surgery Study.

1983 • 79 citations

Prospective randomized study of coronary artery bypass surgery in stable angina pectoris: a progress report on survival.

1982 • 76 citations

National health expenditures, 1986-2000.

1987 • 74 citations

Degree of revascularization in patients with multivessel coronary disease: a report from the National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry.

1988 • 74 citations

Beyond randomized clinical trials: applying clinical experience in the treatment of patients with coronary artery disease.

1986 • 72 citations

Tying clinical research to patient care by use of an observational database

1984 • 65 citations

Baseline characteristics of patients in the national heart, lung, and blood institute percutaneous transluminal coronary angioplasty registry

1984 • 61 citations

Biostatistics in Clinical Medicine.

1988 • 60 citations

Clinical Experience and Predicting Survival in Coronary Disease

1989 • 56 citations

The changing survival benefits of coronary revascularization over time.

1987 • 52 citations

Effect of drug therapy on survival in chronic congestive heart failure

1988 • 51 citations

A life table and Cox regression analysis of patients with combined proximal left anterior descending and proximal left circumflex coronary artery disease: non-left main equivalent lesions (CASS).

1983 • 50 citations

Determinants of successful percutaneous transluminal coronary angioplasty: Report from the National Heart, Lung, and Blood Institute Registry

1984 • 50 citations

Causes of the decrease in cardiovascular mortality

1984 • 49 citations

Comparison of survival of medically and surgically treated coronary disease patients in Seattle Heart Watch: a nonrandomized study.

1982 • 49 citations

Medical Decision Making

1986 • 42 citations

Relative Efficacy of Vasodilator Therapy in Chronic Congestive Heart Failure

1988 • 40 citations

National health expenditures, 1987.

1988 • 37 citations

Natural history of patients with single-vessel disease suitable for percutaneous transluminal coronary angioplasty

1983 • 37 citations

What's wrong with decision analysis? Can the left brain influence the right?

1987 • 35 citations

UNTREATED MILD HYPERTENSION

1982 • 34 citations

Drug treatment trials in hypertension: A review

1985 • 31 citations

Changing efficacy of coronary revascularization. Implications for patient selection.

1988 • 29 citations

Nonfatal myocardial infarction in medically treated patients with coronary artery disease

1980 • 28 citations

The effect of coronary bypass surgery on survival

1983 • 26 citations

Historical background of the national heart, lung, and blood institute registry for percutaneous transluminal coronary angioplasty

1984 • 25 citations

An improving prognosis over time in medically treated patients with coronary artery disease

1983 • 24 citations

“Left main equivalent” coronary artery disease: Its clinical presentation and prognostic significance with nonsurgical therapy

1984 • 24 citations

Computer-Aided Diagnosis of Lower Gastrointestinal Tract Disorders

1975 • 23 citations

Implications of findings in the coronary drug project for secondary prevention trials in coronary heart disease. The coronary; drug project research group.

1981 • 20 citations

Thrombolysis with intravenous human recombinant tissue-type plasminogen activator in acute myocardial infarction: The European experience

1987 • 9 citations

Observations in Particle Physics from Two Neutrinos to the Standard Model

1989 • 8 citations

Socioeconomics of Surgery

1990 • 5 citations

From the Food and Drug Administration

1989 • 2 citations

Deleted Work

1955 • 0 citations