Cancer as an overhealing wound: an old hypothesis revisited

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

2008 • 8,256 citations

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Myofibroblasts and mechano-regulation of connective tissue remodelling

2002 • 3,938 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Epigenetics in Cancer

2008 • 3,424 citations

Regulation of Wound Healing by Growth Factors and Cytokines

2003 • 3,383 citations

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 • 2,597 citations

Transplacental Carcinogenesis by Stilbestrol

1971 • 2,595 citations

Angiogenesis as a therapeutic target

2005 • 2,543 citations

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

2004 • 2,534 citations

Paradoxical roles of the immune system during cancer development

2006 • 2,213 citations

Inflammation in Wound Repair: Molecular and Cellular Mechanisms

2007 • 2,077 citations

The Transcriptional Program in the Response of Human Fibroblasts to Serum

1999 • 1,994 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

2001 • 1,640 citations

Radical causes of cancer

2003 • 1,611 citations

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

2007 • 1,446 citations

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

1975 • 1,445 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

Inflammatory cells during wound repair: the good, the bad and the ugly

2005 • 1,279 citations

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

2005 • 1,225 citations

Neutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring

1995 • 1,166 citations

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

2007 • 1,079 citations

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

2004 • 931 citations

Mechanisms of adverse effects of anti-VEGF therapy for cancer

2007 • 914 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

TGF-β signaling: positive and negative effects on tumorigenesis

2002 • 830 citations

The tumour microenvironment as a target for chemoprevention

2007 • 790 citations

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

2002 • 693 citations

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis

2005 • 678 citations

Cyclooxygenase 2: a molecular target for cancer prevention and treatment

2003 • 651 citations

Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications

2002 • 636 citations

The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance

2008 • 617 citations

The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds

1994 • 597 citations

Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells

2008 • 597 citations

Impaired wound healing in mice with a disrupted plasminogen gene

1996 • 568 citations

Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness

2004 • 557 citations

Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications

2002 • 535 citations

Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts

2004 • 515 citations

VEGF-C–induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

2006 • 506 citations

Accelerated wound closure in neutrophil-depleted mice

2003 • 504 citations

Wound Healing in the PU.1 Null Mouse—Tissue Repair Is Not Dependent on Inflammatory Cells

2003 • 480 citations

Adult vasculogenesis occurs through in situ recruitment, proliferation, and tubulization of circulating bone marrow–derived cells

2004 • 436 citations

Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

2004 • 402 citations

Vascular Endothelial Growth Factor Receptor-3 in Lymphangiogenesis in Wound Healing

2000 • 397 citations

Nrf2 Transcription Factor, a Novel Target of Keratinocyte Growth Factor Action Which Regulates Gene Expression and Inflammation in the Healing Skin Wound

2002 • 392 citations

Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation

2004 • 386 citations

Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis

2006 • 384 citations

Mechanisms of metastasis: Epithelial‐to‐mesenchymal transition and contribution of tumor microenvironment

2007 • 371 citations

Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases.

1996 • 358 citations

Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

2001 • 353 citations

Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?

2007 • 330 citations

The epidermal growth factor receptor: from development to tumorigenesis

2007 • 329 citations

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma

2004 • 320 citations

Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors).

1997 • 320 citations

VEGF‐A promotes tissue repair‐associated lymphatic vessel formation via VEGFR‐2 and the α1β1 and α2β1 integrins

2004 • 313 citations

β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

2002 • 304 citations

c-Met is essential for wound healing in the skin

2007 • 300 citations

Mast cells are required for normal healing of skin wounds in mice

2006 • 295 citations

A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice

2005 • 291 citations

Overexpression of Thrombospondin-1 Decreases Angiogenesis and Inhibits the Growth of Human Cutaneous Squamous Cell Carcinomas

1999 • 287 citations

Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring

2008 • 278 citations

Functional overlap between two classes of matrix-degrading proteases in wound healing

1999 • 273 citations

Extracellular heat shock protein-90α: linking hypoxia to skin cell motility and wound healing

2007 • 267 citations

A crucial role of β1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

2002 • 266 citations

The MET receptor tyrosine kinase in invasion and metastasis

2007 • 242 citations

Clinical Evaluation of Recombinant Human Platelet-Derived Growth Factor for the Treatment of Lower Extremity Ulcers

2006 • 238 citations

VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development

1998 • 232 citations

Wounding and Its Role in RSV-Mediated Tumor Formation

1985 • 225 citations

Vascular Endothelial Growth Factor-C Accelerates Diabetic Wound Healing

2006 • 221 citations

Beta‐catenin regulates wound size and mediates the effect of TGF‐beta in cutaneous healing

2006 • 208 citations

Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice

2000 • 206 citations

Nrf2 as a target for cancer chemoprevention

2005 • 192 citations

Wound-healing defects in mice lacking fibrinogen

2001 • 190 citations

Platelet-Derived Growth Factor-β Receptor Activation Is Essential for Fibroblast and Pericyte Recruitment during Cutaneous Wound Healing

2006 • 176 citations

Paracrine regulation of keratinocyte proliferation and differentiation

2001 • 175 citations

The regulation and role of osteopontin in malignant transformation and cancer

2006 • 174 citations

The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing

2000 • 170 citations

Accelerated Wound Closure in Mice Deficient for Interleukin-10

2007 • 168 citations

Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases

2007 • 163 citations

Cutaneous tissue repair: Practical implications of current knowledge. II

1985 • 155 citations

STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake.

2003 • 142 citations

Molecular Repair, Wound Healing, And Carcinogenesis: Tumor Production A Possible Overhealing?

1973 • 139 citations

Fibroblast differentiation of bone marrow‐derived cells during wound repair

2005 • 135 citations

A delicate balance: TGF‐β and the tumor microenvironment

2007 • 134 citations

Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice

2004 • 132 citations

Loss of Vascular Endothelial Growth Factor A Activity in Murine Epidermal Keratinocytes Delays Wound Healing and Inhibits Tumor Formation

2004 • 128 citations

Involvement of the CXCL12/CXCR4 Pathway in the Recovery of Skin Following Burns

2005 • 128 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

Cancers as Wounds that Do Not Heal: Differences and Similarities between Renal Regeneration/Repair and Renal Cell Carcinoma

2006 • 122 citations

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development

2007 • 120 citations

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus.

1994 • 117 citations

Placenta Growth Factor in Diabetic Wound Healing

2006 • 113 citations

Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice

1990 • 109 citations

Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts

2005 • 107 citations

Delayed wound healing and disorganized neovascularization in transgenic mice expressing the IP-10 chemokine.

1998 • 105 citations

Deletion of the PDGFR-β Gene Affects Key Fibroblast Functions Important for Wound Healing

2004 • 105 citations

Increased Melanoma Growth and Metastasis Spreading in Mice Overexpressing Placenta Growth Factor

2006 • 101 citations

Peroxiredoxin 6 is required for blood vessel integrity in wounded skin

2007 • 93 citations

Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

2003 • 81 citations

The Effects of Cyclooxygenase Isozyme Inhibition onIncisional Wound Healing in Mouse Skin

2002 • 70 citations

The Angiogenesis Inhibitor Vasostatin does not Impair Wound Healing at Tumor-Inhibiting Doses

2001 • 62 citations

Cancer in man at site of prior benign lesion of skin or mucous membrane: a review.

1972 • 52 citations

Transgenic Mice Reveal Novel Activities of Growth Hormone in Wound Repair, Angiogenesis, and Myofibroblast Differentiation

2004 • 47 citations

Lymphangiogenesis in development and disease

2007 • 36 citations