A Randomized, Placebo-Controlled Trial of Certolizumab Pegol (CDP870) for Treatment of Crohn’s Disease

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

2002 • 4,076 citations

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.

1976 • 3,140 citations

Development of a Crohn's Disease Activity Index

1976 • 3,024 citations

Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease

1999 • 2,656 citations

Infliximab Maintenance Therapy for Fistulizing Crohn's Disease

2004 • 2,133 citations

Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

2003 • 1,990 citations

Management of Crohn's Disease in Adults

2009 • 1,162 citations

Efficacy and safety of retreatment with anti–tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease

1999 • 1,107 citations

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

1993 • 848 citations

Quality of life: A valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease

1994 • 703 citations

Tumour necrosis factor alpha in stool as a marker of intestinal inflammation

1992 • 700 citations

Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed

2004 • 617 citations

Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: A randomized controlled trial

2003 • 561 citations

Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.

1993 • 532 citations

Tumour necrosis factor and Crohn's disease.

1997 • 504 citations

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.

1991 • 491 citations

Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease

1997 • 400 citations

Serum levels of C‐reactive protein in Crohn's disease and ulcerative colitis

1982 • 311 citations

Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

1999 • 255 citations

Management of Crohn's disease in adults

2001 • 254 citations

Efficacy of a novel PEGylated humanized anti-TNF fragment (CDP870) in patients with rheumatoid arthritis: a phase II double-blinded, randomized, dose-escalating trial

2002 • 210 citations

A meta-analysis of the placebo rates of remission and response in clinical trials of active crohn’s disease

2004 • 210 citations

A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease

1986 • 164 citations

Mechanisms in failure of infliximab for Crohn's disease

2000 • 135 citations

Inflammatory mediators and acute phase proteins in patients with Crohn's disease and ulcerative colitis.

1997 • 132 citations

A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders

2002 • 119 citations

Statistical Considerations for Multiplicity in Confirmatory Protocols

1996 • 108 citations

Treatment of active Crohn's disease with onercept (recombinant human soluble p55 tumour necrosis factor receptor): results of a randomized, open‐label, pilot study

2003 • 99 citations

Preventing antibodies to infliximab in patients with Crohn's disease: Optimize not immunize

2003 • 88 citations

Use of anti-tumour necrosis factor agents in inflammatory bowel disease

2001 • 49 citations

Serbia and Montenegro

2004 • 48 citations

Evaluation of Different Laboratory Tests and Activity Indices Reflecting the Inflammatory Activity of Crohn's Disease

1992 • 45 citations

Maintenance infliximab for Crohn's disease

2002 • 43 citations

Placebo response in the therapy of Crohnʼs disease: A comprehensive analysis of primary data from 733 patients from 13 randomized, controlled trials

2008 • 10 citations

Placebo Response in the Therapy of Crohn's Disease

2006 • 4 citations