Estimation of apurinic/apyrimidinic sites and phosphotriesters in deoxyribonucleic acid treated with electrophilic carcinogens and mutagens

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

1975 • 3,362 citations

Distribution-Free Statistical Tests

1970 • 1,755 citations

Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.

1975 • 1,030 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES

1963 • 801 citations

Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid

1972 • 586 citations

The reaction of mono- and di-functional alkylating agents with nucleic acids

1961 • 580 citations

DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

1979 • 562 citations

The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis

1975 • 446 citations

Electrophoresis of DNA in agarose gels. Optimizing separations of conformational isomers of double- and single-stranded DNAs

1977 • 304 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

The properties of in templates for RNA polymerase

1973 • 264 citations

DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by

1979 • 247 citations

Alkaline elution analysis, a new approach to the study of DNA single-strand interruptions in cells.

1973 • 197 citations

Carcinogenesis by aromatic amines

1974 • 196 citations

Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N-methyl-N-nitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels

1972 • 185 citations

Hepatocarcinogenicity of Estragole (1-Allyl-4-methoxybenzene) and 1′-Hydroxyestragole in the Mouse and Mutagenicity of 1′-Acetoxyestragole in Bacteria 2

1976 • 181 citations

Reaction of esters of aromatic -hydroxy amines and amides with methionine : A model for binding of amine carcinogens to protein

1966 • 125 citations

Covalent intercalative binding to DNA in relation to the mutagenicity of hydrocarbon epoxides and N-acetoxy-2-acetylaminofluorene.

1978 • 109 citations

Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3′-5′)thymidine

1978 • 98 citations

N-Benzoyloxy-N-methyl-4-aminoazobenzene: its carcinogenic activity in the rat and its reactions with proteins and nucleic acids and their constituents in vitro.

1967 • 98 citations

Removal of minor methylation products 7-methyl adenine and 3-methylguanine from DNA ofescherichia coli treated with dimethyl sulphate

1976 • 84 citations

Sites in nucleic acids reacting with alkylating agents of differing carcinogenicity or mutagenicity

1977 • 77 citations

Effects of depurination on the fidelity of DNA synthesis

1979 • 76 citations

DNA Strand Scission by Benzo[ a ]pyrene Diol Epoxides

1977 • 75 citations

O²- and O⁴-Alkyl pyrimidine nucleosides: stability of the glycosyl bond and of the alkyl group as a function of pH

1978 • 74 citations

CARCINOGENESIS AND INHIBITION OF THE WALKER 256 TUMOR IN THE RAT BY TRANS-4-ACETYLAMINOSTILBENE, ITS N-HYDROXY METABOLITE, AND RELATED COMPOUNDS.

1964 • 73 citations

The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-position of guanine moieties

1978 • 72 citations

The kinetics of the alkaline hydrolysis of phosphotriesters in DNA

1976 • 63 citations

The in vitro and in vivo reaction at the N7-position of guanine of the ultimate carcinogen derived from benzo[a]pyrene

1979 • 59 citations

Structures of hepatic nucleic acid-bound dyes in rats given the carcinogen N-methyl-4-aminoazobenzene.

1975 • 55 citations

The lethal action of ethyl methanesulfonate, nitrogen mustard and myleran on the T7 coliphage

1970 • 47 citations

Adducts from the reaction of N-benzoyloxy-N-methyl-4-aminoazobenzene with deoxyguanosine or DNA in vitro and from hepatic DNA of mice treated with N-methyl- or N,N-dimethyl-4-aminoazobenzene.

1980 • 46 citations

Methylation of rat liver mitochondrial deoxyribonucleic acid by chemical carcinogens and associated alterations in physical properties

1975 • 42 citations

Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

1978 • 41 citations

Crosslinking of methylated DNA by moderate heating at neutral pH

1972 • 31 citations

Dection of strand breaks in ?X 174 RFI and PM2 DNA reacted with ultimate and proximate carcinogens

1977 • 23 citations

Characterization of DNA damages by filtration through nitrocellulose filters: A simple probe for DNA-modifying agents

1979 • 22 citations

Alkali-labile colicinogenic factor E1 DNA molecules formed in the presence of N-methyl-N′-nitro-N-nitrosoguanidine

1977 • 11 citations

The carcinogenic and electrophilic activities of N-benzoyloxy derivatives of N-methyl-4-aminoazobenzene and related dyes.

1975 • 11 citations

Near-ultraviolet light-induced strand breaks in DNA pretreated with the carcinogen, N-acetoxy-2-acetylaminofluorene

1975 • 8 citations