Aldehyde and ketone substrate analogs inhibit the collagenase of Clostridium histolyticum

On the active site of proteases. III. Mapping the active site of papain; specific peptide inhibitors of papain

1968 • 400 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

Transition State Analogues for Enzyme Catalysis

1969 • 381 citations

An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides

1984 • 249 citations

A continuous spectrophotometric assay for Clostridium histolyticum collagenase

1981 • 236 citations

A crystallographic study of the complex of phosphoramidon with thermolysin. A model for the presumed catalytic transition state and for the binding of extended substrates

1977 • 218 citations

Characterization of the individual collagenases from Clostridium histolyticum

1984 • 215 citations

Purification and characterization of a collagenase extracted from rabbit tumours

1975 • 169 citations

Purification and separation of individual collagenases of Clostridium histolyticum using red dye ligand chromatography

1984 • 157 citations

STUDIES ON COLLAGEN

1957 • 136 citations

Comparison of the structures of carboxypeptidase A and thermolysin.

1977 • 129 citations

Synthesis and biological activity of a ketomethylene analog of a tripeptide inhibitor of angiotensin converting enzyme

1980 • 93 citations

Thiohemiacetal formation by inhibitory aldehydes at the active site of papain

1977 • 83 citations

Inhibition of angiotensin converting enzyme: dependence of chloride

1984 • 71 citations

Antiproteolytic aldehydes and ketones: substituent and secondary deuterium isotope effects on equilibrium addition of water and other nucleophiles

1977 • 68 citations

Direct carbon-13 NMR evidence for a tetrahedral intermediate in the binding of a pepstatin analog to porcine pepsin

1982 • 66 citations

.alpha.-Aminoaldehydes: transition state analog inhibitors of leucine aminopeptidase

1982 • 61 citations

Collagenase enzymes from Clostridium: characterization of individual enzymes

1976 • 54 citations

Studying Enzyme Mechanism by ¹³ C Nuclear Magnetic Resonance

1984 • 45 citations

Inhibition of carboxypeptidase A by aldehyde and ketone substrate analogs

1984 • 42 citations

Derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: effect of changes at postions 2 and 5 of the hexanoic acid portion

1982 • 39 citations

Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogs: potent angiotensin converting enzyme inhibitors

1981 • 38 citations

Inhibition of angiotensin-converting enzyme by phosphoramidates and polyphosphates

1982 • 37 citations

Substrate specificity of beta-collagenase from Clostridium histolyticum.

1985 • 35 citations

Kinetic Studies on the Action of Collagenase

1965 • 32 citations

Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue.

1980 • 31 citations

Ketomethyldipeptides I. A new class of angiotensin converting enzyme inhibitors

1984 • 28 citations

Inhibition of the collagenase from Clostridium histolyticum by phosphoric and phosphonic amides

1983 • 25 citations

Purification and characterization of three forms of collagenase from Clostridium histolyticum

1984 • 22 citations

Ketomethyldipeptides II. Effect of modifications of the α-aminoketone portion on inhibition of angiotensin converting enzyme

1984 • 16 citations