The roles of folate and pteridine derivatives in neurotransmitter metabolism

Frontiers in Catecholamine Research

1973 • 1,252 citations

The Biochemistry of Folic Acid and Related Pteridines.

1970 • 1,033 citations

MALARIAL DIABETES

1948 • 829 citations

Biological Methylation: Selected Aspects

1975 • 551 citations

Schizophrenia: A New Approach

1952 • 469 citations

Partial Purification and Characterization of Tryptophan Hydroxylase from Rabbit Hindbrain

1972 • 445 citations

Brain Catechol Synthesis: Control by Brain Tyrosine Concentration

1974 • 367 citations

The glycine cleavage system: Composition, reaction mechanism, and physiological significance

1973 • 360 citations

Control of brain neurotransmitter synthesis by precursor availability and nutritional state

1976 • 271 citations

The Isolation and Characterization of Dihydropteridine Reductase from Sheep Liver

1972 • 256 citations

Regulatory Properties of Soluble and Particulate Rat Brain Tyrosine Hydroxylase

1972 • 230 citations

THE ENZYMATIC CONVERSION OF PHENYLALANINE TO TYROSINE

1957 • 216 citations

Psychotomimetic N -Methylated Tryptamines: Formation in Brain in vivo and in vitro

1972 • 181 citations

In vivo enhancement of tyrosine hydroxylation in rat striatum by tetrahydrobiopterin

1974 • 180 citations

Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds

1961 • 178 citations

Regulation of catecholamine synthesis in the rat brain in vitro by cyclic AMP

1974 • 161 citations

THE METABOLISM IN VIVO OF GLYCINE AND SERINE IN EIGHT AREAS OF THE RAT CENTRAL NERVOUS SYSTEM¹

1970 • 154 citations

The source of choline for acetylcholine synthesis in brain

1976 • 140 citations

Indole(ethyl)amine N-Methyltransferase in Human Brain

1971 • 126 citations

MENTAL EFFECTS OF ANTICONVULSANTS, AND FOLIC ACID METABOLISM

1968 • 126 citations

Anticonvulsant Therapy, Folic Acid and Vitamin B₁₂ Metabolism and Mental Symptoms

1966 • 117 citations

Nonketotic Hyperglycinemia

1995 • 108 citations

Methyltetrahydrofolic Acid Mediates N - and O -Methylation of Biogenic Amines

1973 • 100 citations

Folate deficiency in Crohn's disease: incidence, pathogenesis, and treatment.

1968 • 100 citations

Folate Transport by the Choroid Plexus in Vitro

1975 • 97 citations

7,8-Dihydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources

1974 • 95 citations

N-Methylation of Dopamine to Epinine in Brain Tissue using N-Methyltetrahydrofolic Acid as the Methyl Donor

1972 • 88 citations

5-Methyl-5,6,7,8-tetrahydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with methionine synthetase from bovine brain

1975 • 86 citations

5-Methyltetrahydrofolic Acid Is Not a Methyl Donor for Biogenic Amines: Enzymatic Formation of Formaldehyde

1975 • 85 citations

Inborn Errors of Folate Metabolism

1975 • 85 citations

5-Methyltetrahydrofolic Acid as a Mediator in the Formation of Pyridoindoles

1974 • 83 citations

SUBCELLULAR DISTRIBUTION OF ENZYMES OF TRANSMETHYLATION AND TRANSSULPHURATION IN RAT BRAIN¹

1975 • 80 citations

Methionine Adenosyltransferase Deficiency: New Enzymatic Defect Associated with Hypermethioninemia

1974 • 80 citations

Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase

1975 • 77 citations

Folie acid deficiency and methyl group metabolism in rat brain: Effects of l-dopa

1974 • 77 citations

REGULATION OF CATECHOLAMINE SYNTHESIS IN RAT BRAIN SYNAPTOSOMES¹

1974 • 71 citations

The Biosynthesis of Serine in Mouse Brain Extracts

1965 • 71 citations

Tryptoline Formation by a Preparation from Brain with 5-Methyltetrahydrofolic Acid and Tryptamine

1975 • 67 citations

Dopamine synthesis in rat brain striatal synaptosomes. II. Dibutyryl cyclic adenosine 3':5'-monophosphoric acid and 6-methyltetrahydropterine-induced synthesis increases without an increase in endogenous dopamine release.

1976 • 64 citations

ENZYMATIC FORMATION OF TETRAHYDRO-?-CARBOLINE FROM TRYPTAMINE AND 5-METHYLTETRAHYDROFOLIC ACID IN RAT BRAIN FRACTIONS: REGIONAL AND SUBCELLULAR DISTRIBUTION

1975 • 62 citations

Biochemical Aspects of Schizophrenia

1975 • 60 citations

DISTRIBUTION OF SERINE HYDROXYMETHYLTRANSFERASE AND GLYCINE TRANSAMINASE IN SEVERAL AREAS OF THE CENTRAL NERVOUS SYSTEM OF THE RAT

1974 • 59 citations

ENZYMATIC FORMATION OF TETRAHYDRO-?-CARBOLINE FROM TRYPTAMINE AND 5-METHYLTETRAHYDROFOLIC ACID IN RAT BRAIN FRACTIONS: REGIONAL AND SUBCELLULAR DISTRIBUTION

1975 • 54 citations

Lack of dihydrofolate reductase activity in brain tissue of mammalian species: possible implications¹

1973 • 54 citations

Multiple N-methytransferases for aromatic alkylamines in brain

1973 • 53 citations

Intramitochondrial localization and proposed metabolic significance of serine transhydroxymethylase

1976 • 52 citations

Effect of dibutyryl cyclic adenosine monophosphate on 14C-dopamine biosynthesis in rat brain striatal slices.

1974 • 52 citations

THE OXIDATION OF GLYCINE BY <scp>d</scp>‐AMINO ACID OXIDASE IN EXTRACTS OF MAMMALIAN CENTRAL NERVOUS TISSUE

1969 • 51 citations

Regional Distribution of 5-Methyltetrahydrofolic Acid in Brain

1973 • 47 citations

N-Methylation of biogenic amines—I

1974 • 45 citations

SCHIZOPHRENIA, EPILEPSY, CANCER, METHIONINE, AND FOLATE METABOLISM PATHOGENESIS OF SCHIZOPHRENIA

1975 • 45 citations

Characterization of an enzyme yielding formaldehyde from‐5‐methyltetrahydrofolic acid

1974 • 41 citations

The interconversion of serine and glycine: some further properties of the enzyme system

1957 • 39 citations

5-methyltetrahydrofolate aromatic alkylamine n-methyltransferase: An artefact of 5, 10-methylenetetrahydrofolate reductase activity

1975 • 38 citations

Biochemical Research in Schizophrenia

1971 • 32 citations

DISTRIBUTION OF FOLIC ACID COENZYMES AND FOLATE DEPENDENT ENZYMES IN MOUSE BRAIN

1975 • 32 citations

Methylenetetrahydrofolate reductase in the rat central nervous system: Intracellular and regional distribution

1975 • 31 citations

Synthesis of tetrahydro-β-carbolines from indoleamines via enzymatic formation of formaldehyde from 5-methyltetrahydrofolic acid

1975 • 26 citations

Serine hydroxymethyltransferase in the central nervous system: regional and subcellular distribution studies

1973 • 26 citations

DISTRIBUTION OF FOLIC ACID COENZYMES AND FOLATE DEPENDENT ENZYMES IN MOUSE BRAIN

1975 • 25 citations

Dihydropteridine reductase in rat brain: regional distribution and the effect of catecholamine-depleting drugs

1974 • 25 citations

Folate Metabolism and the Anticonvulsant Efficacy of Phenobarbital

1973 • 21 citations

FOLATE LEVELS IN DEVELOPING MOUSE BRAIN¹

1970 • 20 citations

N5, 10-methylenetetrahydrofolate reductase deficiency and schizophrenia: A working hypothesis

1974 • 19 citations

The role of tetrahydrofolate dehydrogenase in the hepatic supply of tetrahydrobiopterin in rats

1976 • 18 citations

Production of antibodies to sheep liver dihydropteridine reductase: Characterization and use to study the enzyme defect in a variant form of phenylketonuria

1975 • 14 citations

ENZYMATIC N‐METHYLATION OF INDOLEAMINES BY MAMMALIAN BRAIN: FACT OR ARTEFACT?

1976 • 13 citations

Mass spectrometric identification of N-monomethyltryptamine following incubation of tryptamine with brain protein and S-adenosylmethionine or 5-methytetrahydrofolic acid

1976 • 12 citations

Biosynthesis of catecholamines in organotypic cultures of the peripheral autonomic nervous system: Modifications by biopterin and other agents

1975 • 11 citations

Increased brain activity of methylene reductase during early development

1976 • 11 citations

Serum binding of methyltetrahydrofolic acid

1975 • 9 citations

A new hypothesis on the origin of schizophrenia

1974 • 8 citations

Epileptogenic Properties of Folic Acid and N⁵ Methyltetrahydrofolate in Cat

1975 • 8 citations

Increased conversion of a phenylalanine load to tyrosine in tetraiodoglucagon-treated rats

1974 • 6 citations

The effects of folate on neurotransmitter uptake into rat cerebral cortex slices

1976 • 5 citations