Ion channels and epilepsy in man and mouse

KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel

1998 • 1,283 citations

A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

1998 • 1,191 citations

A Potassium Channel Mutation in Neonatal Human Epilepsy

1998 • 1,078 citations

Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1B

1998 • 1,003 citations

Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2

2000 • 986 citations

A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

1998 • 937 citations

The mouse stargazer gene encodes a neuronal Ca2+-channel γ subunit

1998 • 580 citations

Deletion of the KV1.1 Potassium Channel Causes Epilepsy in Mice

1998 • 579 citations

Voltage-Gated Ion Channels and Hereditary Disease

1999 • 539 citations

Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy

1998 • 522 citations

Cloning and Expression of a Novel Member of the Low Voltage-Activated T-Type Calcium Channel Family

1999 • 470 citations

A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy

1999 • 367 citations

Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus

1999 • 364 citations

Single Tottering Mutations Responsible for the Neuropathic Phenotype of the P-type Calcium Channel

1998 • 234 citations

A Second Locus for Familial Generalized Epilepsy with Febrile Seizures Plus Maps to Chromosome 2q21-q33

1999 • 211 citations

Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy

1998 • 199 citations

Voltage‐gated potassium channels: from hyperexcitability to excitement

1999 • 189 citations

Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the α1A subunit of P/Q type calcium channels

1999 • 171 citations

A locus for febrile seizures (FEB3) maps to chromosome 2q23-24

1999 • 164 citations

Altered Calcium Channel Currents in Purkinje Cells of the Neurological Mutant Mouseleaner

1998 • 163 citations

Localization of a Gene for Benign Adult Familial Myoclonic Epilepsy to Chromosome 8q23.3-q24.1

1999 • 158 citations

Autosomal recessive Rolandic epilepsy with paroxysmal exercise-induced dystonia and writer's cramp: Delineation of the syndrome and gene mapping to chromosome 16p12-11.2

1999 • 155 citations

Ion channel genes and human neurological disease: Recent progress, prospects, and challenges

1999 • 146 citations

Whole-Cell and Single-Channel Analysis of P-Type Calcium Currents in Cerebellar Purkinje Cells of Leaner Mutant Mice

1998 • 143 citations

A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions

1999 • 138 citations

Identification of a New Locus for Generalized Epilepsy with Febrile Seizures Plus (GEFS+) on Chromosome 2q24-q33

1999 • 136 citations

Two Types of K⁺Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell

1999 • 130 citations

Excitatory But Not Inhibitory Synaptic Transmission Is Reduced in Lethargic (Cacnb4^lh) and Tottering (Cacna1a^tg) Mouse Thalami

1999 • 126 citations

Presynaptic Ca²⁺Influx at a Mouse Central Synapse with Ca²⁺Channel Subunit Mutations

2000 • 119 citations

Genetic localization of the familial adult myoclonic epilepsy ( FAME ) gene to chromosome 8q24

1999 • 115 citations

Developmental Seizure Susceptibility of Kv1.1 Potassium Channel Knockout Mice

1999 • 114 citations

β Subunit Reshuffling Modifies N- and P/Q-Type Ca2+Channel Subunit Compositions in Lethargic Mouse Brain

1999 • 89 citations

Single gene defects in mice: the role of voltage-dependent calcium channels in absence models

1999 • 88 citations

Specific Alteration of Spontaneous GABAergic Inhibition in Cerebellar Purkinje Cells in Mice Lacking the Potassium Channel Kv1.1

1999 • 81 citations

Mutations in the KCNA1 gene associated with episodic ataxia type‐1 syndrome impair heteromeric voltage‐gated K ⁺ channel function

1999 • 80 citations

Structural and mutational analysis of KCNQ2, the major gene locus for benign familial neonatal convulsions

1999 • 74 citations

Altered Expression and Assembly of N-type Calcium Channel α1B and β Subunits in Epileptic lethargic(lh/lh) Mouse

1998 • 69 citations

Identification of Three Novel Ca²⁺ Channel γ Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication

1999 • 64 citations

Synaptic plasticity in kindling.

1999 • 62 citations

Identification and Cloning of Putative Human Neuronal Voltage-Gated Calcium Channel γ-2 and γ-3 Subunits: Neurologic Implications

1999 • 58 citations

Separation of M‐like current and ERG current in NG108‐15 cells

1999 • 58 citations

Evidence for Linkage of Adolescent-Onset Idiopathic Generalized Epilepsies to Chromosome 8—and Genetic Heterogeneity

1999 • 57 citations

Voltage‐Dependent Calcium Channel Mutations in Neurological Disease

1999 • 53 citations

Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy

1999 • 40 citations

Functional Characterization of a Novel Mutation in KCNA1 in Episodic Ataxia Type 1 Associated with Epilepsy

1999 • 36 citations

Molecular Characterization of Two Members of the T‐Type Calcium Channel Family

1999 • 30 citations

Regulation of Calcium Channel α1A Subunit Splice Variant mRNAs in Kainate-Induced Temporal Lobe Epilepsy

1999 • 27 citations

The voltage gated potassium channel KCNQ2 and idiopathic generalized epilepsy

1999 • 26 citations

Mouse Models of Spike‐Wave Epilepsy

1999 • 23 citations

Ca²⁺-Dependent Inactivation of High-Threshold Ca²⁺ Currents in Hippocampal Granule Cells of Patients With Chronic Temporal Lobe Epilepsy

1999 • 23 citations

Genetic Localization of the Ca²⁺ Channel Gene CACNG2 Near SCA10 on Chromosome 22q13

2000 • 22 citations

Benign familial neonatal epilepsy with mutations in two potassium channel genes

1999 • 20 citations

Kindling induces an asymmetric enhancement of N-type Ca2+ channel density in the dendritic fields of the rat hippocampus

1999 • 12 citations