pH Dependence of chymotrypsin catalysis. Appendix. Substrate binding to dimeric α-chymotrypsin studied by x-ray diffraction and the equilibrium method

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

The effect of pH on the affinities of enzymes for substrates and inhibitors

1953 • 478 citations

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor

1973 • 449 citations

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1972 • 376 citations

Conformational equilibria in α- and δ-chymotrypsin

1972 • 250 citations

Demonstration of the acyl-enzyme mechanism for the hydrolysis of peptides and anilides by chymotrypsin

1973 • 191 citations

Microenvironmental effects on enzyme catalysis. Kinetic study of polyanionic and polycationic derivatives of chymotrypsin

1972 • 153 citations

Equilibrium and rate constants for the interconversion of two conformations of α-chymotrypsin

1971 • 150 citations

On the interpretation of the pH variation of the maximum initial velocity of an enzyme-catalyzed reaction

1954 • 139 citations

On the interaction of the active site of α-chymotrypsin with chromophores: Proflavin binding and enzyme conformation during catalysis

1966 • 139 citations

Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. Stereochemical interpretation

1973 • 125 citations

The charge relay system in chymotrypsin and chymotrypsinogen

1973 • 104 citations

Investigations of the Chymotrypsin-catalyzed Hydrolysis of Specific Substrates

1967 • 95 citations

Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relations

1973 • 80 citations

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of amides. pH dependence of kc and km. kinetic detection of an intermediate

1971 • 68 citations

The Observation of Acyl-Enzyme Intermediates in the α-Chymotrypsin-Catalyzed Reactions of N-Acetyl-L-tryptophan Derivatives at Low pH

1964 • 65 citations

Specificity of α‐chymotrypsin. Dipeptide substrates

1970 • 56 citations

Calorimetric investigations of the binding of inhibitors to α-chymotrypsin. I. Enthalpy of dilution of α-chymotrypsin and of proflavine, and the enthalpy of binding of indole, N-acetyl-D-tryptophan, and proflavine to α-chymotrypsin

1969 • 52 citations

Anomalous pH dependence of K_cat/K_m in enzyme reactions. Rate constants for the association of chymotrypsin with substrates

1973 • 48 citations

Free energies of hydrolysis of amides and peptides in aqueous solution at 25.deg.

1971 • 45 citations

Chymotrypsin catalysis. Evidence for a new intermediate, III

1973 • 44 citations

Nitrogen isotope effects on the chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophanamide

1972 • 39 citations

A continuous, automatic method for the study of rate of hydrolysis of peptides and amides

1965 • 37 citations

Preferential binding of competitive inhibitors to the monomeric form of α-chymotrypsin

1972 • 32 citations

Mechanism of the .alpha.-chymotrypsin-catalyzed hydrolysis of specific amide substrates

1972 • 25 citations

Binding properties of oligomeric α-chymotrypsin

1971 • 24 citations

Concerning a reported change in rate-determining step in chymotrypsin catalysis

1973 • 7 citations