Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Amygdaloid projections to the mesencephalon, pons and medulla oblongata in the cat

1978 • 872 citations

Glutamate‐ and GABA‐containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique

1984 • 851 citations

A perceptual-defensive-recuperative model of fear and pain

1980 • 811 citations

Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray

1976 • 598 citations

Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon

1977 • 566 citations

Intrinsic Mechanisms of Pain Inhibition: Activation by Stress

1984 • 528 citations

Connections between the central nucleus of the amygdala and the midbrain periaqueductal gray: Topography and reciprocity

1991 • 490 citations

Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography.

1987 • 377 citations

Sites of morphine induced analgesia in the primate brain: relation to pain pathways

1974 • 332 citations

Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.

1991 • 330 citations

Peptide immunoreactive neurons in the amygdala and the bed nucleus of the stria terminalis project to the midbrain central gray in the rat

1992 • 259 citations

The amygdala is essential for the expression of conditional hypoalgesia.

1992 • 202 citations

The amygdala is essential for the expression of conditional hypoalgesia.

1992 • 175 citations

Antinociception following opioid stimulation of the basolateral amygdala is expressed through the periaqueductal gray and rostral ventromedial medulla

1998 • 156 citations

The nuclei of origin of brain stem enkephalin and substance P projections to the rodent nucleus raphe magnus

1982 • 147 citations

Possible excitatory amino acid afferents to nucleus raphe dorsalis of the rat investigated with retrograde wheat germ agglutinin and d-[3H]aspartate tracing

1985 • 146 citations

The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests

1994 • 135 citations

Lesions of the amygdala block conditional hypoalgesia on the tail flick test

1993 • 133 citations

III. Comparison of the antinociceptive action of Mu and delta opioid receptor ligands in the periaqueductal gray matter, medial and paramedial ventral medulla in the rat as studied by the microinjection technique

1986 • 133 citations

Role of μ1-opiate receptors in supraspinal opiate analgesia: a microinjection study

1988 • 119 citations

μ and δ opioid synergy between the periaqueductal gray and the rostro-ventral medulla

1994 • 117 citations

Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses

1994 • 106 citations

A mechanism for the analgesic effect of neurotensin as revealed by behavioral and electrophysiological techniques

1984 • 100 citations

Role of neurotensin in the nucleus raphe magnus in opioid-induced antinociception from the periaqueductal gray.

1993 • 93 citations

An electrophysiological characterization of the projection from the central nucleus of the amygdala to the periaqueductal gray of the rat: the role of opioid receptors

1995 • 85 citations

Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.

1996 • 84 citations

Conditional hypoalgesia is attenuated by Naltrexone applied to the periaqueductal gray

1990 • 83 citations

Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstem

1991 • 82 citations

Inhibition of the tail flick reflex following microinjection of morphine into the amygdala

1993 • 78 citations

Glutamate-induced analgesia: Blockade and potentiation by naloxone

1980 • 76 citations

Opioid antagonists in the periaqueductal gray inhibit morphine and β-endorphin analgesia elicited from the amygdala of rats

1996 • 76 citations

Heterogeneous distribution of neurotensin-like immunoreactive neurons and fibers in the midbrain periaqueductal gray of the rat

1987 • 67 citations

Microinfusion of mu but not delta or kappa opioid agonists into the basolateral amygdala results in inhibition of the tail flick reflex in pentobarbital-anesthetized rats.

1995 • 67 citations

The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis

1992 • 65 citations

The μ opiate receptor is responsible for descending pain inhibition originating in the periaqueductal gray region of the rat brain

1988 • 64 citations

Conditioned analgesia in the rat

1980 • 64 citations

The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia

1998 • 63 citations

Elevation of aversive threshold in rats by intra-amygdaloid injection of morphine sulphate

1977 • 62 citations

Role of mu and kappa opioid receptors in conditional fear-induced analgesia: the antagonistic actions of nor-binaltorphimine and the cyclic somatostatin octapeptide, Cys2Tyr3Orn5Pen7-amide.

1989 • 61 citations

Fear is not critical to classically conditioned analgesia: The effects of periaqueductal gray lesions and administration of chlordiazepoxide

1984 • 47 citations

Heterogeneous distribution and upregulation of μ, δ and κ opioid receptors in the amygdala

1987 • 34 citations

Opioid receptors mediating antinociception from β-endorphin and morphine in the periaqueductal gray

1992 • 33 citations

Physiological Mechanisms of the Analgesic Effect of Neurotensin

1992 • 27 citations

Strain differences in reversal of conditional analgesia by opioid antagonists.

1987 • 27 citations

Strain differences in reversal of conditional analgesia by opioid antagonists.

1987 • 23 citations