Functions of the N-terminal Region of Cyclic Nucleotide Phosphodiesterase 3 (PDE 3) Isoforms

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)

1997 • 418 citations

Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)

1999 • 395 citations

Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt

1999 • 365 citations

Isolation and Characterization of PDE9A, a Novel Human cGMP-specific Phosphodiesterase

1998 • 332 citations

Identification and Characterization of a Novel Family of Cyclic Nucleotide Phosphodiesterases

1998 • 283 citations

An Effect of Insulin on Cyclic Adenosine 3′:5′-Monophosphate Phosphodiesterase Activity in Fat Cells

1973 • 245 citations

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

1998 • 242 citations

Insulin-sensitive phosphodiesterase. Its localization, hormonal stimulation, and oxidative stabilization.

1975 • 203 citations

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

1997 • 185 citations

Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases.

1995 • 164 citations

Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.

1992 • 158 citations

Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets.

1988 • 146 citations

Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.

1993 • 137 citations

Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.

1987 • 123 citations

Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase

1984 • 115 citations

Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain.

1992 • 113 citations

Expression of cyclic GMP‐inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: Differential subcellular localization and regulated expression by cyclic AMP

1998 • 113 citations

Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig.

1989 • 110 citations

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1995 • 93 citations

[43] Assay of cyclic nucleotide phosphodiesterase using radiolabeled and fluorescent substrates

1988 • 85 citations

LY195115: a potent, selective inhibitor of cyclic nucleotide phosphodiesterase located in the sarcoplasmic reticulum.

1986 • 83 citations

Alternative Splicing of cAMP-specific Phosphodiesterase mRNA Transcripts

1996 • 82 citations

Characterization of insulin-sensitive phosphodiesterase in fat cells. II. Comparison of enzyme activities stimulated by insulin and by isoproterenol.

1980 • 78 citations

Characterization of Two Recombinant PDE3 (cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase) Isoforms, RcGIP1 and HcGIP2, Expressed in NIH 3006 Murine Fibroblasts and Sf9 Insect Cells

1996 • 64 citations

Identification of the Site in the cGMP-inhibited Phosphodiesterase Phosphorylated in Adipocytes in Response to Insulin and Isoproterenol

1996 • 60 citations

The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity.

1995 • 53 citations

Recombinant Expression of a Type IV, cAMP-Specific Phosphodiesterase: Characterization and Structure−Function Studies of Deletion Mutants

1997 • 50 citations

Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase

1994 • 46 citations

Cytosolic and Sarcoplasmic Reticulum-Associated Low Km, cGMP-Inhibited cAMP Phosphodiesterase in Mammalian Myocardium

1993 • 45 citations

Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis

1996 • 45 citations

Detailed Characterization of a Purified Type 4 Phosphodiesterase, HSPDE4B2B: Differentiation of High- and Low-Affinity (R)-Rolipram Binding

1997 • 45 citations

Mutational mapping of kinetic and pharmacological properties of a human cardiac cAMP phosphodiesterase.

1994 • 42 citations

Inhibitors of cyclic AMP phosphodiesterase. 1. Analogs of cilostamide and anagrelide

1987 • 42 citations

Cytosolic and membrane-bound cyclic nucleotide phosphodiesterases from guinea pig cardiac ventricles

1992 • 38 citations

Expression and mutagenesis of the catalytic domain of cGMP-inhibited phosphodiesterase (PDE3) cloned from human platelets

1997 • 24 citations

Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3)

1998 • 22 citations

Photoaffinity labelling of cyclic GMP-binding proteins in human platelets

1993 • 16 citations

Cyclic nucleotide PDE-3

1998 • 12 citations