Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

1992 • 5,504 citations

Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

Cannabinoid receptor localization in brain.

1990 • 2,248 citations

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1994 • 1,743 citations

Pharmacology of cannabinoid CB1 and CB2 receptors

1997 • 1,448 citations

Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.

1995 • 838 citations

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

1993 • 695 citations

SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.

1998 • 679 citations

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1996 • 555 citations

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

1997 • 457 citations

The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.

1994 • 383 citations

Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells

1993 • 356 citations

Anandamide Amidohydrolase Activity in Rat Brain Microsomes

1995 • 331 citations

Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain

1995 • 234 citations

Regional Differences in Cannabinoid Receptor/G-protein Coupling in Rat Brain

1997 • 197 citations

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase

1995 • 186 citations

Effects of anandamide on cannabinoid receptors in rat brain membranes

1994 • 179 citations

Synthesis and Pharmacology of a Very Potent Cannabinoid Lacking a Phenolic Hydroxyl with High Affinity for the CB2 Receptor

1996 • 168 citations

Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain.

1998 • 162 citations

Head Group Analogs of Arachidonylethanolamide, the Endogenous Cannabinoid Ligand

1996 • 158 citations

Aminoalkylindole binding in rat cerebellum: selective displacement by natural and synthetic cannabinoids.

1993 • 157 citations

Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea‐pig small intestine

1992 • 157 citations

The biodisposition and metabolism of anandamide in mice.

1997 • 154 citations

Molecular Aspects of Cannabinoid Receptors

1997 • 137 citations

[1] Measurement of receptor-stimulated guanosine 5′-O-(γ-thio)triphosphate binding by G proteins

1994 • 136 citations

Human Platelets and Polymorphonuclear Leukocytes Synthesize Oxygenated Derivatives of Arachidonylethanolamide (Anandamide): Their Affinities for Cannabinoid Receptors and Pathways of Inactivation

1998 • 118 citations

Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid

1997 • 114 citations

Cross‐tolerance between delta‐9‐tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212‐2 and anandamide

1993 • 107 citations

Cannabinoid receptor stimulation of guanosine-5′-O-(3-[35S]thio)triphosphate binding in rat brain membranes

1996 • 107 citations

Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain

1997 • 91 citations

Characterization of Ligand Binding to the Cannabinoid Receptor of Rat Brain Membranes Using a Novel Method: Application to Anandamide

1995 • 81 citations

Purification and Reconstitution of the Ca2+-Pumping ATPase of Red Blood Cells

1994 • 64 citations