Improved circulating half-life and efficacy of an antibody-interleukin 2 immunocytokine based on reduced intracellular proteolysis.

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.

1996 • 671 citations

A Theoretical Model of γ-Globulin Catabolism

1964 • 440 citations

Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth.

1987 • 242 citations

Antibody-targeted interleukin 2 stimulates T-cell killing of autologous tumor cells.

1992 • 179 citations

Targeted Interleukin-2 Therapy for Spontaneous Neuroblastoma Metastases to Bone Marrow

1997 • 176 citations

T cell-mediated eradication of murine metastatic melanoma induced by targeted interleukin 2 therapy.

1996 • 152 citations

Antigens associated with a human lung adenocarcinoma defined by monoclonal antibodies.

1984 • 142 citations

A recombinant antibody-interleukin 2 fusion protein suppresses growth of hepatic human neuroblastoma metastases in severe combined immunodeficiency mice.

1994 • 103 citations

Biological activity and in vivo clearance of anti-tumor antibody/cytokine fusion proteins

1993 • 95 citations

Antibody-IL-12 Fusion Proteins Are Effective in SCID Mouse Models of Prostate and Colon Carcinoma Metastases

1998 • 93 citations

High level expression and secretion of Fc-X fusion proteins in mammalian cells

1998 • 80 citations

Improving the efficacy of antibody-interleukin 2 fusion proteins by reducing their interaction with Fc receptors.

1999 • 42 citations

Induction of persistent tumor-protective immunity in mice cured of established colon carcinoma metastases.

1998 • 33 citations