Influence of renal failure on the disposition of morphine, morphine-3-glucuronide and morphine-6-glucuronide in sheep during intravenous infusion with morphine.

Statistical principles in experimental design.

1962 • 27,228 citations

Limitations of creatinine as a filtration marker in glomerulopathic patients

1985 • 1,216 citations

Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide

1990 • 446 citations

The Disposition of Morphine and Its 3- and 6-Glucuronide Metabolites in Humans and Animals, and the Importance of the Metabolites to the Pharmacological Effects of Morphine

1996 • 215 citations

The pharmacokinetics of morphine and morphine glucuronides in kidney failure

1993 • 202 citations

Normal Metabolism of Morphine in a Cirrhosis

1981 • 164 citations

Glucuronidation of Drugs

1992 • 162 citations

Isolation and Identification of Morphine 3- and 6-Glucuronides, Morphine 3,6-Diglucuronide, Morphine 3-Ethereal Sulfate, Normorphine, and Normorphine 6-Glucuronide as Morphine Metabolites in Humans

1977 • 136 citations

Kinetics of morphine in patients with renal failure

1987 • 85 citations

High-performance liquid chromatographic determination of morphine and its 3- and 6-glucuronide metabolites: improvements to the method and application to stability studies

1991 • 84 citations

The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive‐care patients.

1992 • 83 citations

Morphine-6-Glucuronide might Mediate the Prolonged Opioid Effect of Morphine in Acute Renal Failure

1990 • 78 citations

Long lasting respiratory depression induced by morphine‐6‐glucuronide?

1989 • 60 citations

Biliary excretion and enterohepatic recirculation of morphine-3-glucuronide in rats.

1995 • 51 citations

Renal failure does not impair the metabolism of morphine.

1986 • 48 citations

PHARMACOKINETICS OF MORPHINE IN TWO CHILDREN BEFORE AND AFTER LIVER TRANSPLANTATION

1986 • 38 citations

Disposition of morphine and its 3- and 6-glucuronide metabolites during morphine infusion in the sheep.

1993 • 23 citations

Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the rat

1974 • 17 citations

Changes in renal function with reductions in renal mass.

1977 • 9 citations

Creatinine and inulin clearance at the different nitrogen and energy intake in sheep

1988 • 6 citations