Divergent Metabolism of Apolipoproteins E3 and E4 by Cells

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Apolipoprotein E polymorphism and Alzheimer's disease

1993 • 1,076 citations

Apolipoprotein E: Structure-Function Relationships

1994 • 801 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

1981 • 568 citations

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

1994 • 453 citations

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

1990 • 451 citations

The apolipoprotein ε4 allele in patients with Alzheimer's disease

1993 • 401 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Apolipoprotein E Affects the Rate of Alzheimer Disease Expression: β-Amyloid Burden Is a Secondary Consequence Dependent on APOE Genotype and Duration of Disease

1994 • 332 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

1995 • 277 citations

Rate and equilibrium constants for binding of apo-E HDL _c (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDL _c

1979 • 215 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid

1995 • 156 citations

Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls

1994 • 153 citations

Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease

1994 • 81 citations

Glycosylphosphatidylinositol-anchored and core protein-intercalated heparan sulfate proteoglycans in rat ovarian granulosa cells have distinct secretory, endocytotic, and intracellular degradative pathways.

1992 • 62 citations

ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

1995 • 56 citations

The intracellular fate of apolipoprotein E is tau dependent and apoe allelespecific

1996 • 35 citations