COBAS AMPLICOR: fully automated RNA and DNA amplification and detection system for routine diagnostic PCR

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase.

1991 • 2,688 citations

Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization.

1995 • 1,619 citations

The "megaprimer" method of site-directed mutagenesis.

1990 • 1,174 citations

Simultaneous Amplification and Detection of Specific DNA Sequences

1992 • 1,108 citations

Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes.

1989 • 1,025 citations

Use of uracil DNA glycosylase to control carry-over contamination in polymerase chain reactions

1990 • 953 citations

Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells

1995 • 692 citations

Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection

1994 • 576 citations

An improved technique for the in situ detection of DNA after polymerase chain reaction amplification.

1991 • 186 citations

Post-PCR sterilization: a method to control carryover contamination for the polymerase chain reaction

1991 • 159 citations

Quantitation of HIV-1 proviral DNA relative to cellular DNA by the polymerase chain reaction

1990 • 131 citations

Validation and population studies of the loci LDLR, GYPA, HBGG, D7S8, and Gc (PM loci), and HLA-DQ alpha using a multiplex amplification and typing procedure.

1995 • 128 citations

Detection of Legionella species in sewage and ocean water by polymerase chain reaction, direct fluorescent-antibody, and plate culture methods

1993 • 127 citations

A method for typing polymorphism at the HLA‐A locus using PCR amplification and immobilized oligonucleotide probes

1994 • 108 citations

Specificity of expression of the muscle and brain dystrophin gene promoters in muscle and brain cells

1990 • 65 citations

Detection of Legionella species in reclaimed water and air with the EnviroAmp Legionella PCR kit and direct fluorescent antibody staining

1995 • 63 citations

Applications of PCR to the Analysis of Biological Evidence

1989 • 60 citations

Cloning of PCR products after defined cohesive termini are created with T4 DNA polymerase

1990 • 36 citations

HLA typing for bone marrow transplantation. New polymerase chain reaction-based methods.

1995 • 29 citations

A high-performance system for automation of the polymerase chain reaction.

1991 • 27 citations

The use of europium (Eu3+) labelled primers in PCR amplification of specific target DNA

1991 • 26 citations

A DNA sequence for the discrimination of Neisseria gonorrhoeae from other Neisseria species

1991 • 19 citations

Thermostable DNA Polymerases

1995 • 14 citations

Nucleic acid amplification mediated microbial identification.

1993 • 11 citations

Polymerase Chain Reaction in Infectious Disease Diagnosis

1994 • 9 citations

NONISOTOPIC DETECTION OF PCR PRODUCTS

1990 • 6 citations

Preimplantation Diagnosis of Genetic Disease

1995 • 4 citations

DNA Diagnosis in Monogenic Diseases

1994 • 3 citations