EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1992 • 1,787 citations

The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts

1994 • 1,069 citations

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment]

1996 • 739 citations

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS–family transcription factor, ERG

1994 • 727 citations

SYT–SSXGene Fusion as a Determinant of Morphology and Prognosis in Synovial Sarcoma

1998 • 646 citations

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

1993 • 560 citations

Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

1993 • 537 citations

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.

1993 • 501 citations

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

1995 • 466 citations

A new member of the ETS family fused to EWS in Ewing tumors

1997 • 386 citations

DNA-Binding and Transcriptional Activation Properties of the EWS-FLI-1 Fusion Protein Resulting from the t(l1;22) Translocation in Ewing Sarcoma

1994 • 304 citations

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

1997 • 274 citations

Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing's sarcoma of the extremities.

1997 • 254 citations

Fusion of anETS-family gene,EIAF, toEWS by t(17;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy

1996 • 229 citations

Molecular Assays for Chromosomal Translocations in the Diagnosis of Pediatric Soft Tissue Sarcomas

1995 • 215 citations

Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma.

1997 • 203 citations

The Emerging Molecular Genetics of Sarcoma Translocations

1995 • 181 citations

EWS/Fli-1 chimeric protein is a transcriptional activator.

1993 • 171 citations

A Novel Chimera Gene betweenEWSandE1A-F, Encoding the Adenovirus E1A Enhancer-Binding Protein, in Extraosseous Ewing's Sarcoma

1996 • 170 citations

Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing's sarcoma, in children and young adults.

1995 • 168 citations

EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.

1994 • 161 citations

Reverse Transcriptase PCR Amplification of EWS/FLI-1 Fusion Transcripts as a Diagnostic Test for Peripheral Primitive Neuroectodermal Tumors of Childhood

1993 • 148 citations

EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro.

1996 • 144 citations

Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. A specific diagnostic assay.

1995 • 142 citations

Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts.

1995 • 134 citations

The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities.

1994 • 132 citations

Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation

1993 • 105 citations

Gene fusions encoding chimaeric transcription factors in solid tumours

1996 • 97 citations

Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein.

1993 • 89 citations

Small round blue cell tumors in bone: prognostic factors correlated to Ewing's sarcoma and neuroectodermal tumors.

1996 • 77 citations

Is neuro-ectodermal differentiation of Ewing's sarcoma of bone associated with an unfavourable prognosis?

1995 • 74 citations

Ewingʼs sarcoma and extracranial primitive neuroectodermal tumors

1992 • 64 citations

Structure and expression of human Fli-1 gene.

1992 • 64 citations

SRE elements are binding sites for the fusion protein EWS-FLI-1

1996 • 49 citations

Comparison of Soft Tissue Ewing's Sarcoma and Peripheral Neuroectodermal Tumor

1996 • 39 citations

Treatment of femoral Ewing's sarcoma

1996 • 21 citations

Ewingʼs sarcoma and extracranial peripheral neuroectodermal tumors

1995 • 11 citations