MICROCARRIERS AND THE PROBLEM OF HIGH DENSITY CELL CULTURE

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

1967 • 1,821 citations

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

1979 • 1,228 citations

Serum-free cell culture: a unifying approach

1980 • 964 citations

Growth of Cell-strains and Primary Cells on Micro-carriers in Homogeneous Culture

1967 • 688 citations

Tissue culture, methods and applications

1974 • 634 citations

[5] Media and growth requirements

1979 • 331 citations

Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium.

1979 • 306 citations

Muscle and splanchnic glutamine and glutamate metabolism in postabsorptive and starved man

1971 • 280 citations

THE SPECIFIC AMINO ACID REQUIREMENTS OF A MAMMALIAN CELL (STRAIN L) IN TISSUE CULTURE

1955 • 279 citations

Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts

1978 • 274 citations

The metabolic fates of amino acids and the formation of glutamine in skeletal muscle.

1978 • 242 citations

Influence of Oxygen and Culture Media on Plating Efficiency of Some Mammalian Tissue Cells

1972 • 228 citations

The role of glutamine in the oxidative metabolism of malignant cells.

1972 • 224 citations

Fatty Acid and 3-β-Hydroxysterol Synthesis in the Perfused Rat Liver

1973 • 213 citations

Alanine and glutamine synthesis and release from skeletal muscle. I. Glycolysis and amino acid release.

1976 • 207 citations

The Utilization of Carbohydrates by Human Cell Cultures

1958 • 206 citations

Spin Filter Culture: The Propagation of Mammalian Cells in Suspension

1969 • 177 citations

Purification of kidney epithelial cell growth inhibitors.

1980 • 174 citations

Oxygen demand and supply in cell culture

1981 • 161 citations

Growth of functional primary cultures of kidney epithelial cells in defined medium

1980 • 159 citations

Energy metabolism in respiration‐deficient and wild type chinese hamster fibroblasts in culture

1976 • 152 citations

Optimization of growth surface parameters in microcarrier cell culture

1979 • 151 citations

The effect of oxygen tension on the growth and metabolism of WI‐38 cells

1976 • 151 citations

Rapid clonal growth and serial passage of human diploid fibroblasts in a lipid-enriched synthetic medium supplemented with epidermal growth factor, insulin, and dexamethasone.

1981 • 139 citations

Glucose Metabolism in Rat Skeletal Muscle at Rest: Effect of Starvation, Diabetes, Ketone Bodies and Free Fatty Acids

1974 • 129 citations

Lactate: A major product of glutamine metabolism by human diploid fibroblasts

1980 • 119 citations

Why do tumor cells have a high aerobic glycolysis?

1976 • 114 citations

Density-dependent regulation of growth of BSC-1 cells in cell culture: growth inhibitors formed by the cells.

1978 • 111 citations

Microcarrier cell culture: New methods for research-scale application

1977 • 108 citations

THE ROLE OF GLUTAMINE IN PROTEIN BIOSYNTHESIS IN TISSUE CULTURE

1957 • 91 citations

Kinetics of gas diffusion in mammalian cell culture systems. II. Theory

1968 • 90 citations

Glucose metabolism by adult hepatocytes in primary culture and by cell lines from rat liver

1978 • 86 citations

The uptake of amino acids by mouse cells (strain LS) during growth in batch culture and chemostat culture: the influence of cell growth rate

1967 • 79 citations

Homogeneous cultivation of animal cells for the production of virus and virus products

1969 • 78 citations

Microcarrier Cultures of Animal Cells

1973 • 78 citations

Oxygen microenvironment and respiratory oscillations in cultured mammalian cells

1974 • 75 citations

Growth of cultured mammalian cells on secondary glucose sources

1974 • 72 citations

Evidence for the Release of Individual Amino-acids from the Resting Human Forearm

1965 • 68 citations

Glutamine and the regulation of DNA replication and cell multiplication in fibroblasts

1981 • 61 citations

The production of foot‐and‐mouth disease virus from BHK 21 C 13 cells grown on the surface of DEAE sephadex A50 beads

1976 • 60 citations

Primary culture of human diploid cells and its long-term transfer in a serum-free medium

1981 • 56 citations

Amino acid utilization by L-M strain mouse cells in a chemically defined medium

1972 • 55 citations

Evidence that Glutamine Is a Precursor of Asparagine in a Human Cell in Tissue Culture

1957 • 54 citations

Primary suspension culture of calf anterior pituitary cells on a microcarrier surface

1975 • 50 citations

Glutamate Oxidation in 6C3HED Lymphoma: Effects of L-Asparaginase on Sensitive and Resistant Lines

1974 • 48 citations

Ammonia effects in cultures of normal and transformed 3T3 cells

1972 • 48 citations

Amino-acid metabolism of tissue cells in vitro

1948 • 47 citations

Kinetics of gas diffusion in mammalian cell culture systems. I. Experimental

1968 • 47 citations

Altered glucose transport kinetics in murine sarcoma virus‐transformed BALB/3T3 clones

1970 • 42 citations

Role of glutamine in purine synthesis and in guanine nucleotide formation in normal fibroblasts and in fibroblasts deficient in hypoxanthine phosphoribosyltransferase activity

1973 • 39 citations

Selective utilization of amino acids by mammalian cell cultures

1962 • 33 citations

Differences in oxygen‐dependent regulation of enzymes between tumor and normal cell systems in culture

1981 • 33 citations

THE PARTICIPATION OF BLOOD PROTEINS IN THE METABOLISM OF TISSUE CELLS

1947 • 24 citations

Glucose and amino acid metabolism in an established line of skeletal muscle cells

1978 • 24 citations

Pyruvate carboxylase and phosphoenolpyruvate carboxykinase in cultured human fibroblasts

1977 • 23 citations

Amino Acid Utilization by 929-L Fibroblasts in Chemically Defined Media<xref ref-type="fn" rid="FN2">2</xref>

1963 • 23 citations

The quantitative requirements of human diploid cells (strain MRC-5) for amino acids, vitamins and serum

1975 • 23 citations

Increase in Glutaminase Activity during the Growth Cycle of Cultured Human Diploid Fibroblasts

1980 • 21 citations

Microcarrier culture: Applications in biological production and cell biology

1981 • 18 citations

Growth of cells in hormonally defined media : abstracts of papers presented at the Ninth Cold Spring Harbor Conference on Cell Proliferation, September 1-September 6, 1981

1981 • 18 citations

The amino acid metabolism of differentiating skeletal myoblasts in vitro

1959 • 17 citations

Ketone bodies, glucose and glutamine as lipogenic precursors in human diploid fibroblasts

1981 • 16 citations

On the Protein Metabolism of Tissue Cells <italic>in Vitro</italic><xref ref-type="fn" rid="fn1"><sup>2</sup></xref>

1953 • 13 citations

Selection of mitotic Chinese hamster ovary cells from microcarriers

1980 • 12 citations

Induction of mitochondrial phosphoenolpyruvate carboxykinase in cultured human fibroblasts

1978 • 11 citations

Glucose and amino acid metabolism in neonatal rat skeletal muscle in tissue culture

1980 • 10 citations

The Snakes of Australia: an Illustrated and Descriptive Catalogue of all the known Species

1870 • 7 citations

Activities of Enzymes Required for the Conversion of 4-Carbon TCA Cycle Compounds to 3-Carbon Glycolytic Compounds in Human Diploid Fibroblasts

1981 • 7 citations