Antigen Presentation by B Cells and Its Significance in T-B Interactions

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 1,046 citations

Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice.

1978 • 791 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Proteinases in mammalian cells and tissues

1978 • 701 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 611 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

1978 • 488 citations

THE INTERACTION OF SOLUBLE HORSERADISH PEROXIDASE WITH MOUSE PERITONEAL MACROPHAGES IN VITRO

1972 • 431 citations

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

1984 • 422 citations

THE REQUIREMENT OF MORE THAN ONE ANTIGENIC DETERMINANT FOR IMMUNOGENICITY

1969 • 412 citations

Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.

1981 • 391 citations

Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.

1962 • 386 citations

Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen.

1984 • 351 citations

Studies on the capacity of B cells to serve as antigen-presenting cells.

1981 • 349 citations

Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release.

1984 • 346 citations

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.

1983 • 312 citations

Interaction Between Antigen‐Presenting Cells and Primed T Lymphocytes

1978 • 303 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

Opinion

1978 • 283 citations

Antigen presentation by supported planar membranes containing affinity-purified I-Ad.

1984 • 281 citations

Cellular Sites of Immunologic Unresponsiveness

1970 • 202 citations

Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells.

1982 • 202 citations

Requirements for the processing of antigens by antigen-presenting B cells. I. Functional comparison of B cell tumors and macrophages.

1982 • 201 citations

Antigen presentation by normal B cells, B cell tumors, and macrophages: functional and biochemical comparison.

1982 • 199 citations

Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation.

1984 • 182 citations

Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin.

1981 • 176 citations

Studies on hypersensitivity. II. Delayed hypersensitivity to denatured proteins in guinea pigs.

1959 • 163 citations

Major histocompatibility complex-restricted, polyclonal B cell responses resulting from helper T cell recognition of antiimmunoglobulin presented by small B lymphocytes.

1985 • 154 citations

Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells.

1981 • 153 citations

THE IMMUNOGENICITY OF ANTIGEN BOUND TO THE PLASMA MEMBRANE OF MACROPHAGES

1970 • 149 citations

B cells as antigen-presenting cells: the requirement for B cell activation.

1983 • 147 citations

Antigen presentation by splenic B cells: resting B cells are ineffective, whereas activated B cells are effective accessory cells for T cell responses.

1985 • 145 citations

Production of interleukin 1 activity by normal human peripheral blood B lymphocytes.

1985 • 138 citations

T-lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation.

1976 • 120 citations

The carrier effect in the secondary response to hapten-protein conjugates. V. Use of antilymphocyte serum to deplete animals of helper cells

1971 • 104 citations

Separation of T and B lymphocytes and their role in the mixed lymphocyte reaction.

1974 • 100 citations

T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2− andI-A restricted

1980 • 99 citations

Constraints in T‐B cooperation related to epitope topology on E. coli β‐galactosidase. I. The fine specificity of T cells dictates the fine specificity of antibodies directed to conformation‐ dependent determinants

1985 • 97 citations

Expression of M locus differences by B cells but not T cells

1974 • 97 citations

Antigen-specific. I region-restricted interactions in vitro between tumor cell lines and T cell hybridomas.

1982 • 96 citations

Requirements for the processing of antigen by antigen-presenting B cells. II. Biochemical comparison of the fate of antigen in B cell tumors and macrophages.

1982 • 93 citations

Macrophage Activation of Allogeneic Lymphocyte Proliferation in the Guinea Pig Mixed Leukocyte Culture

1975 • 92 citations

Immunogenic properties of modified antigen E. II. Ability of urea-denatured antigen and alpha-polypeptide chain to prime T cells specific for antigen E.

1975 • 92 citations

“B”-cell Stimulation of Allogeneic T-cell Proliferation in Mixed Lymphocyte Cultures

1973 • 90 citations

Persistence of Antigen on the Surface of Macrophages

1969 • 89 citations

Antigen presentation by hapten-specific B lymphocytes. II. Specificity and properties of antigen-presenting B lymphocytes, and function of immunoglobulin receptors.

1985 • 87 citations

T cells discriminate between Ia antigens expressed on allogeneic accessory cells and B cells: a potential function for carbohydrate side chains on Ia molecules.

1983 • 86 citations

Separation of T and B Lymphocytes and Their Role in the Mixed Lymphocyte Reaction

1974 • 84 citations

Conditions required for expression of membrane IL 1 on B cells.

1985 • 84 citations

Antigen Handling by Guinea Pig Macrophages: Further Evidence for the Sequestration of Antigen Relevant for Activation of Primed T Lymphocytes

1977 • 83 citations

Antigen recognition by T cells and B cells: Recognition of cross-reactivity between native and denatured forms of globular antigens

1980 • 83 citations

An Ia-restricted epitope-specific circuit regulating T cell-B cell interaction and antibody specificity

1983 • 81 citations

Presentation of antigen by B cells: functional dependence on radiation dose, interleukins, cellular activation, and differential glycosylation.

1985 • 78 citations

Characterization of the stimulator cells in the murine primary mixed leukocyte response.

1980 • 78 citations

Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle.

1983 • 75 citations

Accessory cell stimulation of T cell proliferation requires active antigen processing, Ia-restricted antigen presentation, and a separate nonspecific 2nd signal.

1981 • 75 citations

Differential glycosylation of murine B cell and spleen adherent cell Ia antigens.

1981 • 74 citations

IMMUNE RESPONSES AGAINST NATIVE AND CHEMICALLY MODIFIED ALBUMINS IN MICE

1972 • 74 citations

Activation of mouse lymphocytes inhibits induction of rapid cell death by x-irradiation.

1985 • 71 citations

Immunogenic Properties of Modified Antigen E

1975 • 68 citations

Specific lymphocyte-activating determinants expressed on mouse macrophages

1975 • 67 citations

The Fate of Anti-Ig-Surface Ig Complexes on B Lymphocytes

1973 • 65 citations

B-Cell Alloantigens Determined by the H-2 Linked Ir Region Are Associated with Mixed Lymphocyte Culture Stimulation

1974 • 60 citations

T cell clones with dual specificity for M1s and various major histocompatibility complex determinants.

1981 • 60 citations

Absence of H-2 restriction in primary and secondary mixed-lymphocyte reactions to strong M1s determinants.

1980 • 57 citations

EVIDENCE FOR A ROLE OF Ir-ASSOCIATED ALLOANTIGENS IN MIXED LYMPHOCYTE CULTURE STIMULATION

1974 • 54 citations

Repertoires of T cells directed against a large protein antigen, beta-galactosidase. I. Helper cells have a more restricted specificity repertoire than proliferative cells.

1982 • 53 citations

Accessory cell-dependent selection of specific T-cell functions

1983 • 52 citations

Capacity of small B cell‐enriched populations to stimulate mixed lymphocyte reactions: marked differences between irradiated vs. mitomycin C‐treated stimulators

1985 • 51 citations

T cell recognition in the mixed lymphocyte response. I. Non-T, radiation-resistant splenic adherent cells are the predominant stimulators in the murine mixed lymphocyte reaction.

1979 • 50 citations

Accessory cell requirement in the proliferative response of T lymphocytes to hemocyanin

1980 • 44 citations

Denaturation of Lysozyme by Freund's Complete Adjuvant

1973 • 39 citations

Studies on the Distribution of Surface Immunoglobulins on Human B-Lymphocytes

1973 • 39 citations

T cell recognition in the mixed lymphocyte response. II. Ia-positive splenic adherent cells are required for non-I region-induced stimulation.

1981 • 36 citations

Macrophage/T‐Lymphocyte Interaction in the Immune Response to PPD in Humans

1979 • 31 citations

Murine B Lymphocyte Heterogeneity: Distribution of Complement Receptor-Bearing and Minor Lymphocyte-Stimulating B Lymphocytes among Cells with Different Densities of Total Surface Ig and IgM

1977 • 31 citations

T Cell Recognition in the Mixed Lymphocyte Response

1979 • 27 citations

Alloantigen presentation by B cells: two types of alloreactive T cell hybridomas, B cell-reactive and B cell-nonreactive.

1985 • 24 citations

Studies on non-H-2-linked lymphocyte-activating determinants

1977 • 21 citations

HLA‐D‐restricted Antigen Activation of Sensitized T Lymphocytes: Studies on the Ability of HLA‐D/DR‐expressing B Lymphocytes to Substitute for Macrophages in Antigen Activation

1979 • 18 citations

Immunologic effects of whole-body ultraviolet (uv) irradiation

1981 • 15 citations

Transfer of antigen-presenting capacity to Ia-negative cells upon fusion with Ia-bearing liposomes

1985 • 15 citations

Interaction of T Cells with Allogeneic Macrophages in Mixed Leukocyte Cultures in Rats

1977 • 13 citations

Evaluation of accessory cell heterogeneity. I. Differential accessory cell requirement for T helper cell activation and for T‐B cooperation

1985 • 13 citations

Synthesis and immunological properties of the oligolysyl-N^iε-dinitrophenyllysine and oligolysylalanylalanylalanyl-N^iε-dinitrophenyllysine peptide series

1974 • 13 citations

Antigen degradation by macrophages as an obligatory step in the presentation of antigen to T lymphocytes

1979 • 12 citations

Transfer of antigen-presenting capacity to Ia-negative cells upon fusion with Ia-bearing liposomes.

1985 • 11 citations

Augmentation of Guinea Pig T Lymphocyte Proliferative Response to Antigens in the Presence of Purified B Cells

1980 • 11 citations

B cell activation potential of insulin‐reactive T cells in H‐2^b mice

1984 • 7 citations

Antigen-specific T helper clones in a nonresponder strain require augmentation for expression of helper activity. Evidence for a possible antigen presentation defect in B cells.

1984 • 7 citations

Peptide map comparisons of epidermal and spleen H-2 molecules

1981 • 5 citations