Effects of Drugs and Metals on Heme Degradation by the Heme Oxygenase System

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.

1970 • 396 citations

Metals as Regulators of Heme Metabolism

1977 • 338 citations

Dose-response effects of various metal ions on rat liver metallothionein, glutathione, heme oxygenase, and cytochrome P-450

1980 • 241 citations

Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450

1975 • 223 citations

Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions

1976 • 202 citations

Purification and properties of heme oxygenase from pig spleen microsomes.

1978 • 189 citations

Inducible heme oxygenase in the kidney: a model for the homeostatic control of hemoglobin catabolism

1971 • 131 citations

THE ENZYMATIC DEGRADATION OF HEMOGLOBIN TO BILE PIGMENTS BY MACROPHAGES

1971 • 130 citations

Induction of heme oxygenase by hemin in cultured pig alveolar macrophages

1978 • 90 citations

Mechanism of increase of heme oxygenase activity induced by hemin in cultured pig alveolar macrophages

1979 • 61 citations

Incorporation of exogenous heme into hepatic cytochrome P-450 in vivo.

1979 • 58 citations

Reaction of the microsomal heme oxygenase with cobaltic protoporphyrin IX, and extremely poor substrate.

1978 • 52 citations

Induction of hepatic heme oxygenase activity by bromobenzene

1979 • 52 citations

Regulation of synthesis and intracellular translocation of δ-aminolevulinate synthase by heme and its relation to the heme saturation of tryptophan pyrrolase in rat liver

1981 • 50 citations

Tryptophan pyrrolase in haem regulation. Experiments with administered haematin and the relationship between the haem saturation of tryptophan pyrrolase and the activity of 5-aminolaevulinate synthase in rat liver

1980 • 40 citations

Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.

1976 • 36 citations

Effects of Administration of Cobalt Chloride and Cobalt Protoporphyrin on δ-Aminolevulinate Synthase in Rat Liver1

1978 • 36 citations

Cell‐free synthesis of rat liver δ‐aminolevulinate synthase and possible occurrence of processing of the enzyme protein in the course of its translocation from the cytosol into the mitochondrial matrix

1980 • 35 citations

Loss of Liver Cytochrome P-450 Caused by Chemicals

1978 • 28 citations

Heme degradation by the microsomal heme oxygenase system

1980 • 26 citations

Accelerated conversion of heme to bile pigments caused in the liver by carbon disulfide and other sulfur-containing chemicals.

1978 • 21 citations

Effect of 3,5-Diethoxycarbonyl-l,4-dihydrocollidine on Degradation of Liver Haem

1973 • 19 citations

Cadmium-induced alterations in the activities of hepatic .DELTA.-aminolevulinic acid synthetase and heme oxygenase in mice.

1979 • 10 citations