Modulation of clinical drug resistance in a B cell lymphoma patient by the protein kinase inhibitor 7-hydroxystaurosporine: presentation of a novel therapeutic paradigm.

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

An evolutionary perspective on apoptosis

1994 • 758 citations

Apoptosis of Malignant Human B Cells by Ligation of CD20 With Monoclonal Antibodies

1998 • 576 citations

Induction of a Common Pathway of Apoptosis by Staurosporine

1994 • 491 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

1996 • 451 citations

Control of programmed cell death in normal and leukemic cells: new implications for therapy

1993 • 297 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

1990 • 262 citations

A simplified method of detection of clonal rearrangements of the T-cell receptor-gamma chain gene.

1992 • 261 citations

EPOCH chemotherapy: toxicity and efficacy in relapsed and refractory non-Hodgkin's lymphoma.

1993 • 247 citations

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.

1997 • 241 citations

Relationship of p53, bcl-2, and Tumor Proliferation to Clinical Drug Resistance in Non-Hodgkin's Lymphomas

1997 • 230 citations

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.

1996 • 221 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.

1994 • 161 citations

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.

1995 • 137 citations

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

1993 • 133 citations

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1993 • 119 citations

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation.

1989 • 107 citations

Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.

1995 • 92 citations

Analysis of the anticancer drugs VP 16-213 and VM 26 and their metabolites by high-performance liquid chromatography

1980 • 90 citations

Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.

1991 • 76 citations

Pharmacokinetics of vincristine infusion.

1981 • 41 citations

Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells.

1994 • 34 citations