Interaction of complement with Neisseria meningitidis and Neisseria gonorrhoeae

HUMAN IMMUNITY TO THE MENINGOCOCCUS

1969 • 1,290 citations

Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency.

1984 • 636 citations

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

1975 • 474 citations

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

1978 • 415 citations

Neisseria meningitidis and Neisseria gonorrhoeae Bacteremia Associated with C6, C7, or C8 Deficiency

1979 • 259 citations

Inherited deficiency of the second component of complement. Rheumatic disease associations.

1976 • 238 citations

Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human sera.

1976 • 231 citations

Importance of complement source in bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide

1983 • 199 citations

Immunoglobulin G antibodies directed against protein III block killing of serum-resistant Neisseria gonorrhoeae by immune serum.

1986 • 189 citations

Capsular Polysaccharides as Human Vaccines

1983 • 187 citations

Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation

1987 • 186 citations

Pathogenic neisseriae

1990 • 175 citations

Prevalence of Congenital or Acquired Complement Deficiency in Patients with Sporadic Meningococcal Disease

1983 • 173 citations

Separation of self from non-self in the complement system

1987 • 159 citations

The meningococcus and mechanisms of pathogenicity

1982 • 159 citations

Bactericidal activity of meningococcal antisera. Blocking by IgA of lytic antibody in human convalescent sera.

1975 • 148 citations

Killing of Neisseria meningitidis by Human Neutrophils: Implications for Normal and Complement-Deficient Individuals

1987 • 138 citations

Properdin deficiency in a family with fulminant meningococcal infections.

1982 • 135 citations

Familial Properdin Deficiency and Fatal Meningococcemia

1987 • 133 citations

Studies on the mechanism of bacterial resistance to complement-mediated killing. IV. C5b-9 forms high molecular weight complexes with bacterial outer membrane constituents on serum-resistant but not on serum-sensitive Neisseria gonorrhoeae.

1983 • 115 citations

Localization of complement component 3 on Streptococcus pneumoniae: anti-capsular antibody causes complement deposition on the pneumococcal capsule

1983 • 114 citations

IgA blocks IgM and IgG-initiated immune lysis by separate molecular mechanisms.

1983 • 109 citations

Mechanism of action of blocking immunoglobulin G for Neisseria gonorrhoeae.

1985 • 107 citations

The role of antibody in the activation of the alternative complement pathway

1983 • 95 citations

Host Defense Against Neisseria meningitidis Requires a Complement-Dependent Bactericidal Activity

1979 • 94 citations

The Function of Antibody and Complement in the Lysis of Bacteria

1987 • 88 citations

Characterization of Serum Resistance of Neisseria gonorrhoeae that Disseminate

1982 • 82 citations

The meningococcus and mechanisms of pathogenicity.

1982 • 75 citations

Group-Specific Polysaccharide Antigen and Humoral Antibody Response in Disease due to Neisseria meningitidis

1972 • 72 citations

Gonococci and Meningococci

1988 • 65 citations

The role of C9 in complement-mediated killing of Neisseria.

1981 • 65 citations

The Biochemistry of Opsonization: Central Role of the Reactive Thiolester of the Third Component of Complement

1984 • 62 citations

Activation of complement by serum-resistant Neisseria gonorrhoeae. Assembly of the membrane attack complex without subsequent cell death.

1982 • 60 citations

Monoclonal antibodies directed against gonococcal protein I vary in bactericidal activity.

1985 • 55 citations

Complement and meningococcal infection.

1976 • 53 citations

Dissemination of gonococcal infection is associated with delayed stimulation of complement-dependent neutrophil chemotaxis in vitro

1982 • 51 citations

Prevalence of Deficits of Complement Components in Patients with Recurrent Meningococcal Infections

1983 • 47 citations

Bactericidal but not nonbactericidal C5b-9 is associated with distinctive outer membrane proteins in Neisseria gonorrhoeae.

1985 • 42 citations

Serum bactericidal action and activation of the classic and alternate complement pathways by Neisseria gonorrhoeae.

1978 • 41 citations

Opsonophagocytosis of Neisseria gonorrhoeae: Interaction of Local and Disseminated Isolates with Complement and Neutrophils

1985 • 41 citations

Specificity of antibodies against Neisseria gonorrhoeae that stimulate neutrophil chemotaxis. Role of antibodies directed against lipooligosaccharides.

1987 • 36 citations

Screening for complement deficiencies in unselected patients with meningitis.

1987 • 33 citations

THE SERUM BACTERICIDAL SYSTEM: ULTRASTRUCTURAL CHANGES IN NEISSERIA MENINGITIDIS EXPOSED TO NORMAL RAT SERUM

1969 • 33 citations

Complement abnormalities during an epidemic of group B meningococcal infection in children.

1986 • 26 citations

The multifunctional role of C3: Structural analysis of its interactions with physiological ligands

1986 • 26 citations

Bactericidal Activity for Neisseria meningitidis in Properdin-Deficient Sera

1987 • 24 citations

STUDIES OF GONOCOCCAL INFECTION. II. THE BACTERIOLYTIC POWER OF THE WHOLE DEFIBRINATED BLOOD OF PATIENTS WITH GONOCOCCAL ARTHRITIS 1

1937 • 23 citations

Natural Serum Bactericidal Activity Against Neisseria meningitidis Isolates from Disseminated Infections in Normal and Complement-Deficient Hosts

1985 • 21 citations

Magnitude of bacteremia and complement activation duringNeisseria meningitidis infection: Study of two co-primary cases with different clinical presentations

1984 • 17 citations

Complement

1983 • 16 citations

Activation of complement byNeisseria meningitidis

1981 • 16 citations

Assembly of the membrane attack complex promotes decay of the alternative pathway C3 convertase on Neisseria gonorrhoeae.

1988 • 11 citations

Strain-specific direct binding of properdin accounts for variable lysis of Neisseria gonorrhoeae

1988 • 5 citations

The contribution of the alternative and classical complement pathways to gonococcal killing and C3 fixation

1988 • 4 citations

Activation of complement by Neisseria meningitidis

1981 • 1 citations