Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2).

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Structure of ubiquitin refined at 1.8 Å resolution

1987 • 1,682 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

Traitement statistique des erreurs dans la determination des structures cristallines

1952 • 1,284 citations

Stereochemically restrained refinement of macromolecular structures

1985 • 614 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Ribbon models of macromolecules

1987 • 519 citations

The use of an imaging proportional counter in macromolecular crystallography

1987 • 494 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

The Yeast Cell Cycle Gene CDC34 Encodes a Ubiquitin-Conjugating Enzyme

1988 • 435 citations

A 25-kilodalton ubiquitin carrier protein (E2) catalyzes multi-ubiquitin chain synthesis via lysine 48 of ubiquitin.

1990 • 212 citations

A uniform isopeptide-linked multiubiquitin chain is sufficient to target substrate for degradation in ubiquitin-mediated proteolysis.

1990 • 136 citations

Cloning of a 16-kDa ubiquitin carrier protein from wheat and Arabidopsis thaliana. Identification of functional domains by in vitro mutagenesis.

1991 • 94 citations

Three-dimensional structure of a ubiquitin-conjugating enzyme (E2).

1992 • 94 citations

Ubiquitin conjugation by the yeast RAD6 and CDC34 gene products. Comparison to their putative rabbit homologs, E2(20K) AND E2(32K).

1991 • 89 citations

Isolation of a cDNA encoding a mammalian multiubiquitinating enzyme (E225K) and overexpression of the functional enzyme in Escherichia coli

1991 • 69 citations

Cloning and characterization of a 20-kDa ubiquitin carrier protein from wheat that catalyzes multiubiquitin chain formation in vitro.

1991 • 47 citations