A retrovirus expressing the 12S adenoviral E1A gene product can immortalize epithelial cells from a broad range of rat tissues.

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Monoclonal antibodies provide specific intramolecular markers for the study of epithelial tonofilament organization.

1982 • 477 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses

1979 • 395 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site

1982 • 353 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

Expression of human class II major histocompatibility complex antigens using retrovirus vectors.

1987 • 257 citations

Complete transformation by adenovirus 2 requires both E1A proteins

1984 • 243 citations

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides

1985 • 227 citations

Growth of Cells in Hormonally Defined Media

1983 • 187 citations

Cell Culture Methods for Molecular and Cell Biology

1985 • 184 citations

Purification of kidney epithelial cell growth inhibitors.

1980 • 174 citations

Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides

1986 • 166 citations

8 Pathogenesis of Retrovirus-induced Disease

1982 • 161 citations

Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products.

1984 • 153 citations

Dissection of overlapping functions within the adenovirus type 5 E1A gene.

1984 • 146 citations

Lytic and transforming functions of individual products of the adenovirus E1A gene

1986 • 136 citations

Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection

1984 • 121 citations

An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested human cells

1985 • 112 citations

Structure and Function of the Transforming Genes of Human Adenoviruses and SV40

1980 • 108 citations

Tumorigenicity of fibroblast lines expressing the adenovirus E1a, cellular p53, or normal c-myc genes.

1986 • 85 citations

Purification and properties of a rat liver protein that specifically inhibits the proliferation of nonmalignant epithelial cells from rat liver.

1982 • 78 citations

Malignant transformation of human embryo retinoblasts by cloned adenovirus 12 DNA

1982 • 75 citations

Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression

1985 • 69 citations

Retinal Tumor Induced in the Baboon by Human Adenovirus 12

1980 • 66 citations

Adenovirus E1A 12S protein induces DNA synthesis and proliferation in primary epithelial cells in both the presence and absence of serum

1987 • 59 citations

Inhibitors of glycosylation reverse retroviral interference

1982 • 57 citations

Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation.

1985 • 57 citations

In vitro neoplastic transformation of uveal and retinal tissue by oncogenic DNA viruses.

1968 • 40 citations

Properties of rat cells transformed by DNA plasmids containing adenovirus type 12 E1 DNA or specific fragments of the E1 region: comparison of transforming frequencies.

1985 • 30 citations

Tumorigenicity and in vitro characteristics of rat liver epithelial cells and their adenovirus‐transformed derivatives

1980 • 28 citations