A Folate- and Methyl-Deficient Diet Alters the Expression of DNA Methyltransferases and Methyl CpG Binding Proteins Involved in Epigenetic Gene Silencing in Livers of F344 Rats

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

2005 • 1,995 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

2000 • 938 citations

The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

2003 • 720 citations

Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b

2003 • 705 citations

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

1999 • 624 citations

Dnmt3a and Dnmt3b Are Transcriptional Repressors That Exhibit Unique Localization Properties to Heterochromatin

2001 • 440 citations

5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal

2005 • 425 citations

Changes in DNA Methylation in Neoplasia: Pathophysiology and Therapeutic Implications

2001 • 414 citations

DNA Methylation, Cancer Susceptibility, and Nutrient Interactions

2004 • 392 citations

Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

2002 • 354 citations

Folate and DNA Methylation: A Mechanistic Link between Folate Deficiency and Colorectal Cancer?

2004 • 339 citations

The impact of metabolism on DNA methylation

2005 • 308 citations

Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis

2005 • 244 citations

Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis

2002 • 209 citations

Mechanisms of DNA Damage, DNA Hypomethylation, and Tumor Progression in the Folate/Methyl-Deficient Rat Model of Hepatocarcinogenesis

2003 • 193 citations

Role of Human Ribosomal RNA (rRNA) Promoter Methylation and of Methyl-CpG-binding Protein MBD2 in the Suppression of rRNA Gene Expression

2004 • 191 citations

Processive Methylation of Hemimethylated CpG Sites by Mouse Dnmt1 DNA Methyltransferase

2004 • 188 citations

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency

2005 • 180 citations

Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open Chromatin Structure

2002 • 157 citations

Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat

1997 • 156 citations

Gene-Nutrient Interactions in One-Carbon Metabolism

2005 • 142 citations

Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues

2004 • 126 citations

Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

2003 • 122 citations

RETRACTED: Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer

2004 • 120 citations

Nutrigenetics in Cancer Research—Folate Metabolism and Colorectal Cancer

2005 • 117 citations

DNA Methyltransferase 3b Regulates Nerve Growth Factor-Induced Differentiation of PC12 Cells by Recruiting Histone Deacetylase 2

2005 • 108 citations

DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma

2005 • 104 citations

The Thymine DNA Glycosylase MBD4 Represses Transcription and Is Associated with Methylated p16^INK4a and hMLH1 Genes

2005 • 102 citations

De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats

2002 • 94 citations

Suppression of Metallothionein Gene Expression in a Rat Hepatoma Because of Promoter-specific DNA Methylation

2000 • 90 citations

Folate, DNA stability and colo-rectal neoplasia

2004 • 80 citations

Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1

2003 • 75 citations

Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

2004 • 75 citations

Expression of DNA methyltransferases in multistep hepatocarcinogenesis

2003 • 72 citations

The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1

2005 • 55 citations

Role of de Novo DNA Methyltransferases and Methyl CpG-binding Proteins in Gene Silencing in a Rat Hepatoma

2002 • 53 citations

Epigenetic regulation of metallothionein‐i gene expression: Differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins

2005 • 44 citations

MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland

2002 • 42 citations

The Controversial Denouement of Vertebrate DNA Methylation Research

2005 • 32 citations

Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver

2003 • 30 citations

Analytical Procedure for Determination of S-Adenosylmethionine, S-Adenosyl-Homocysteine, and S-Adenosylethionine in Same Isocratic HPLC Run, with a Procedure for Preparation and Analysis of the Analog S-Adenosylhomocysteine Sulfoxide

1995 • 18 citations