Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor.

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

1995 • 408 citations

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1995 • 285 citations

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

1990 • 277 citations

Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes.

1990 • 237 citations

Measurement of guanine nucleotide-binding protein activation by A1 adenosine receptor agonists in bovine brain membranes: stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding.

1993 • 154 citations

Adenosine receptor-mediated inhibition of rat cerebral cortical adenylate cyclase by a GTP-dependent process.

1980 • 141 citations

The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins

1995 • 51 citations

Adenosine A1 and A2b receptors coupled to distinct interactive signaling pathways in intestinal muscle cells.

1995 • 50 citations

Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine.

1994 • 43 citations

Cardiac functional responses to adenosine by PD 81,723, an allosteric enhancer of the adenosine A1 receptor

1993 • 36 citations

Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists.

1992 • 27 citations

Functional activity of the adenosine binding enhancer, PD 81,723, in the in vitro hippocampal slice

1991 • 25 citations

Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine.

1994 • 22 citations

Adenosine receptor‐induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon

1992 • 20 citations

Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine.

1994 • 18 citations

Irreversible inactivation of the beta-adrenoreceptor by a partial agonist. Evidence for selective loss of the agonist high affinity binding sites.

1985 • 10 citations