Tissue inhibitor of metalloproteinases (timp) regulates extracellular type i collagen degradation by chondrocytes and endothelial cells

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators.

1982 • 362 citations

Purification of rabbit bone inhibitor of collagenase

1981 • 352 citations

Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components

1983 • 222 citations

Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.

1985 • 220 citations

Isolation of a nonmitogenic angiogenesis factor from wound fluid.

1982 • 219 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. I. Production of procollagenase and prostromelysin exceeds expression of proteolytic activity.

1986 • 215 citations

Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen

1985 • 195 citations

An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases

1981 • 171 citations

Neutral metallo-proteinases of rabbit bone. Separation in latent forms of distinct enzymes that when activated degrade collagen, gelatin and proteoglycans

1978 • 149 citations

Purification of an endogenous activator of procollagenase from rabbit synovial fibroblast culture medium.

1983 • 134 citations

Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator

1980 • 134 citations

Immunolocalization of tissue inhibitor of metalloproteinases (timp) in human cells characterization and use of a specific antiserum

1985 • 116 citations

Characterization of a specific antiserum for mammalian collagenase from several species: immunolocalization of collagenase in rabbit chondrocytes and uterus

1986 • 103 citations

Identification and partial characterization of an inhibitor of collagenase from rabbit bone

1977 • 90 citations

Metalloproteinase inhibitors from bovine cartilage and body fluids

1984 • 62 citations

Effects of products from macrophages, blood mononuclear cells and of retinol on collagenase secretion and collagen synthesis in chondrocyte culture

1982 • 54 citations

Inhibition of type I collagen film degradation by tumour cells using a specific antibody to collagenase and the specific tissue inhibitor of metalloproteinases (TIMP)

1985 • 38 citations

The effects of razoxane (ICRF 159) on the production of collagenase and inhibitor (TIMP) by stimulated rabbit articular chondrocytes

1983 • 13 citations