The β-Adrenergic Blocking Agents Pharmacology and Structure-Activity Relationships

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

The Pharmacological Basis of Therapeutics

1941 • 2,217 citations

FRACTIONATION AND CHARACTERIZATION OF A CYCLIC ADENINE RIBONUCLEOTIDE FORMED BY TISSUE PARTICLES

1958 • 1,055 citations

On some physiological actions of ergot

1906 • 980 citations

THE RELATION OF ADENOSINE-3', 5'-PHOSPHATE AND PHOSPHORYLASE TO THE ACTIONS OF CATECHOLAMINES AND OTHER HORMONES

1960 • 852 citations

FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE BY TISSUE PARTICLES

1958 • 802 citations

The Pharmacological Basis of Therapeutics

1941 • 778 citations

UNESTERIFIED FATTY ACID IN HUMAN BLOOD PLASMA 1

1956 • 707 citations

On the reaction of cells and of nerve‐endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari

1905 • 581 citations

Adenyl Cyclase

1962 • 555 citations

Enzymes: Units of Biological Structure and Function

1956 • 526 citations

PHARMACOLOGY OF A NEW ADRENERGIC BETA-RECEPTOR-BLOCKING COMPOUND (NETHALIDE)

1962 • 508 citations

A NEW ADRENERGIC

1964 • 485 citations

Use of Propranolol (Inderal) in Treatment of Hypertension

1964 • 407 citations

Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol.

1958 • 373 citations

The role of the sympathetic nervous system in the metabolism of free fatty acids

1959 • 362 citations

EFFECT OF A β-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS

1964 • 309 citations

Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase

1963 • 305 citations

EFFECT OF HYPERGLYCEMIC-GLYCOGENOLYTIC FACTOR AND EPINEPHRINE ON LIVER PHOSPHORYLASE

1951 • 247 citations

Actions of Hormones on Molecular Processes

1965 • 223 citations

Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol.

1958 • 218 citations

Pharmacological and toxicological properties of two new beta-adrenergic receptor antagonists.

1965 • 208 citations

Currents in Biochemical Research

1947 • 196 citations

The receptors for epinephrine and norepinephrine (adrenergic receptors).

1959 • 180 citations

The effect of adrenergic blocking agents on some metabolic actions of catecholamines.

1961 • 178 citations

Hypotensive Action of Pronethalol

1964 • 178 citations

Beta-adrenergic Receptor Blockade in Cardiac Arrhythmias

1963 • 169 citations

Use of Propranolol in Angina Pectoris

1965 • 165 citations

CLINICAL PHARMACOLOGY OF A BETA-ADRENERGIC-BLOCKING AGENT (NETHALIDE)

1962 • 163 citations

Phosphorus Metabolism

1951 • 159 citations

EFFECT OF ADRENERGIC BLOCKADE ON GLUCOSE AND FATTY-ACID MOBILISATION IN MAN

1962 • 153 citations

Andrenergic receptive mechanism of canine ileum.

1959 • 150 citations

On the Physiology of the Salivary Secretion

1878 • 145 citations

THE ANTIARRHYTHMIC ACTIONS OF BETA ADRENERGIC BLOCKING AGENTS.

1965 • 143 citations

The effect of epinephrine and other glycogenolytic agents on the phosphorylase A content of muscle

1956 • 132 citations

Propranolol (Inderal) in Disturbances of Cardiac Rhythm

1965 • 129 citations

Factors Affecting Fat Mobilization from Adipose Tissue

1960 • 129 citations

Antifibrillatory action

1962 • 122 citations

THE EFFECTS OF PRONETHALOL AND ITS DEXTRO ISOMER UPON EXPERIMENTAL CARDIAC ARRHYTHMIAS.

1965 • 118 citations

Effect of Adrenergic Blocking Agents on Fatty Acid Mobilization during Fasting.

1959 • 114 citations

Effect of Pronethalol in Angina Pectoris

1963 • 113 citations

A Molecular Theory of Drug Action Based on Induced Conformational Perturbations of Receptors¹

1964 • 112 citations

BLOCKADE OF SOME METABOLIC EFFECTS OF CATECHOLAMINES BY N-ISOPROPYL METHOXAMINE (B.W. 61-43).

1964 • 110 citations

Effect of Propranolol (Inderal) in Angina Pectoris: Preliminary Report

1964 • 107 citations

Neue broncholytisch hochwirksame Körper der Adrenalinreihe

1940 • 103 citations

Double-blind Trail to Propranolol (Inderal) in Angina Pectoris

1965 • 103 citations

IPROVERATRIL: EXPERIMENTAL DATA ON CORONARY DILATATION AND ANTIARRHYTHMIC ACTION.

1964 • 101 citations

LIPOLYSIS IN ADIPOSE TISSUE: EFFECTS OF dl-3,4-DICHLOROISOPROTERENOL AND RELATED COMPOUNDS

1963 • 94 citations

Carcinogenic Action of Pronethalol

1963 • 91 citations

Effects of Beta-Adrenergic Blockade with Propranolol in Patients with Atrial Arrhythmias

1965 • 89 citations

Clinical experiences with propranolol

1965 • 82 citations

Effects of Dichloroisoproterenol on Blood Sugar and Plasma Free Fatty Acids.

1962 • 80 citations

ACTIONS OF AUTONOMIC DRUGS ON PHOSPHORYLASE ACTIVITY AND FUNCTION.

1965 • 80 citations

Currents in Biochemical Research, 1956

1956 • 79 citations

THE EFFECTS OF SYMPATHECTOMY ON THE ELECTROCARDIOGRAM AND EFFORT TOLERANCE IN ANGINA PECTORIS

1964 • 76 citations

The influence of dichloroiso-proterenol (DCI) and related compounds upon ouabain and acetylstrophanthidin induced cardiac arrhythmias.

1961 • 75 citations

A New Bio-isostere : Alkylsulphonamidophenethanolamines

1964 • 68 citations

Local Anæsthetic Activity of the β-Receptor Antagonist, Pronethalol

1964 • 64 citations

Dissociation of the augmentation of cardiac contractile force from the activation of myocardial phosphorylase by catecholamines.

1963 • 60 citations

THE ACTION OF NETHALIDE UPON EXPERIMENTALLY INDUCED CARDIAC ARRHYTHMIAS.

1964 • 60 citations

RELATION BETWEEN PHARMACOLOGIC AUGMENTATION OF CARDIAC CONTRACTILE FORCE AND THE ACTIVATION OF MYOCARDIAL GLYCOGEN PHOSPHORYLASE

1960 • 60 citations

An analysis of adrenergic blocking activity.

1961 • 57 citations

Antagonism of epinephrine-induced cardiac arrhythmias by 4-(2-isopropylamino-1-hydroxyethyl)-methanesulfonanilide (MJ 1999) .

1966 • 57 citations

THE HAeMODYNAMIC EFFECTS OF -SYMPATHETIC BLOCKADE

1964 • 56 citations

Effect of some new beta-adrenergic blocking agents on certain metabolic responses to catecholamines.

1965 • 52 citations

BLOCKADE OF SOME CARDIAC ACTIONS OF ADRENALINE BY DICHLOROISOPROTERENOL

1960 • 51 citations

Pronethalol in Treatment of Ventricular Arrhythmias During Anaesthesia

1964 • 51 citations

Adrenergic Mechanisms: A Ciba Foundation Symposium

1962 • 50 citations

Reversal of Digitalis Intoxication by Beta-Adrenergic Blockade with Pronethalol

1964 • 48 citations

The role of arterial pressure in the induction of idioventricular rhythms under cyclopropane anesthesia.

1948 • 47 citations

Cardiovascular pharmacology of two new beta-adrenergic receptor antagonists.

1965 • 46 citations

BETA-ADRE NERGIC BLOCKADE WITH PRONETHALOL DURING ANAESTHESIA

1964 • 44 citations

The effect of catecholamines on muscle glycogen and phosphorylase activity.

1963 • 43 citations

ALTERATIONS OF ADRENERGIC RESPONSES BY N-ISOPROPYLMETHOXAMINE.

1964 • 42 citations

EFFECTS OF β-SYMPATHETIC BLOCKADE ON NON-ESTERIFIED-FATTY-ACID AND CARBOHYDRATE METABOLISM AT REST AND DURING EXERCISE

1964 • 36 citations

CARDIOVASCULAR EFFECTS OF ANOXIA AND THE INFLUENCE OF A NEW BETA ADRENERGIC RECEPTOR BLOCKING DRUG.

1965 • 36 citations

The Relationship Between Chemical Structure and Pharmacological Activity

1962 • 34 citations

The pharmacological activity of epinephrine and related dihydroxyphenylalkylamines.

1949 • 34 citations

Use of Pronethalol in Phaeochrome Tumours

1963 • 34 citations

Propranolol and ventricular arrhythmias with halothane

1965 • 33 citations

A New Series of Substances which Block the Adrenergic β-Receptors

1963 • 29 citations

The Effects of Nicotinic Acid, Phentolamine and Nethalide on the Plasma Free Fatty Acids and the Blood Pressure in the Dog A Comparative Study

1963 • 29 citations

Influence of Sympathomimetic Pressor Drugs on Arrhythmias Caused by Multiple Stimuli

1959 • 27 citations

Effects of Alpha and Beta Adrenergic Blocking Agents on Cyclopropane-Catecholamine Cardiac Arrhythmias

1965 • 27 citations

PROPRANOLOL IN ATTEMPTED MAINTENANCE OF SINUS RHYTHM AFTER ELECTRICAL DEFIBRILLATION

1964 • 26 citations

Sensitization to ventricular fibrillation. I Sensitization by a substituted propiophenone, U-0882.

1960 • 26 citations

Antagonism of Hydrocarbon Anesthetic-Epinephrine Arrhythmias in Dogs by Nethalide, a Dichloroisoproterenol Analogue

1963 • 26 citations

Klinische Untersuchung über die Wirkung von Isoptin und Isoptin S bei Patienten mit Koronarinsuffizienz

1963 • 25 citations

Adrenergic blockade produced by the dichloro analogs of epinephrine, arterenol and isoproterenol.

1959 • 25 citations

Bronchodilators, N-Substituted Derivatives of 1-(3',4'-Dihydroxyphenyl)-2-aminoethanol (Arterenol)

1954 • 24 citations

THE EFFECT OF AN ADRENERGIC BETA-RECEPTOR ANTAGONIST ON THE CARDIOVASCULAR SYSTEM OF THE DOG.

1964 • 24 citations

Effect of Pronethalol on Some Inhibitory Actions of Catecholamines

1963 • 23 citations

The actions of dichloroisoproterenol in the dog heart-lung preparation and the isolated guinea-pig atrium.

1960 • 20 citations

COMPARISON OF THE PRESSOR ACTION OF SOME OPTICAL ISOMERS OF SYMPATHOMIMETIC AMINES

1943 • 18 citations

Competitive Antagonism Between Isoproterenol and a New Beta-Receptor Adrenergic Blocking Agent, Propranolol.

1965 • 18 citations

[Isoptin studies on normal subjects and patients with coronary disease].

1963 • 17 citations

CANINE BLOOD SUGAR AND LACTIC ACID RESPONSES TO ADRENERGIC AMINES AFTER ADRENERGIC BLOCK

1962 • 15 citations

Synthesis and Pharmacological Properties of Some Derivatives of p-Aminophenylethanolamine

1963 • 15 citations

Action of epinephrine and norepinephrine in broken cell preparations.

1959 • 15 citations

Blockade of the beta adrenergic receptors.

1960 • 14 citations

Selektive Sympathikolyse und Myokardfunktion¹

1964 • 14 citations

The Pharmacological Action of 1‐o‐Chlorophenyl‐2‐Isopropylaminoethanol (Isoprophenamine)11Generic name. A Bronchodilator**Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Ind.

1956 • 11 citations

THE EFFECTS OF A NEW BETA ADRENERGIC BLOCKING AGENT (NETHALIDE; ALDERLIN) UPON THE GENERAL AND CORONARY HAEMODYNAMICS OF THE INTACT ANIMAL

1963 • 11 citations

Some effects of dibenzyl-beta-chlorethylamine (dibenamine) on the mammalian heart.

1949 • 10 citations

Pre- and Post-Operative Care of Patients with Phaeochromocytomas

1965 • 10 citations

PREVENTION AND CORRECTION OF VENTRICULAR ARRHYTHMIAS BY DICHLOROISOPROTERENOL IN DOGS ANESTHETIZED WITH CYCLOPROPANE

1961 • 9 citations

INOTROPIC AND CHRONOTROPIC EFFECTS OF DICHLOROISOPROTERENOL ON RAT ATRIA.

1965 • 6 citations

An experimental investigation of the cholinolytic activity of some new synthetic esters of amino-alcohols.

1956 • 5 citations

Evaluation of Bronchodilator Preparations with Special Reference to Isoprophenamine, a New Oral Bronchodilator

1963 • 4 citations

Synthese des Sauerstoffisologen des Adrenalins und der isomeren Verbindung

1947 • 4 citations

CARDIOVASCULAR EFFECTS OF PRONETHALOL IN THE DOG

1965 • 3 citations

PRONETHALOL (“ALDERLIN”) A BETA ADRENERGIC INHIBITOR: PHARMACOLOGICAL OBSERVATIONS AND TRIAL IN ANGINA PECTORIS

1964 • 2 citations

[ISOPTIN (D-365), CLINICAL STUDIES ON THE TREATMENT OF CORONARY HEART DISEASE].

1965 • 2 citations