The Human Leukocyte Test System

A simple technique for demonstrating centromeric heterochromatin

1972 • 4,206 citations

Amino Acid Metabolism in Mammalian Cell Cultures

1959 • 4,025 citations

New Giemsa method for the differential staining of sister chromatids

1974 • 3,198 citations

Cytological detection of mutagen–carcinogen exposure by sister chromatid exchange

1975 • 1,333 citations

Nutrition of Animal Cells in Tissue Culture. I. Initial Studies on a Synthetic Medium.,

1950 • 1,066 citations

Handbook of molecular cytology

1969 • 1,011 citations

Localization of heterochromatin in human chromosomes

1971 • 965 citations

An improved nutrient solution for diploid Chinese hamster and human cell lines

1963 • 890 citations

Microfluorometric Detection of Deoxyribonucleic Acid Replication in Human Metaphase Chromosomes

1973 • 838 citations

THE ORGANIZATION AND DUPLICATION OF CHROMOSOMES AS REVEALED BY AUTORADIOGRAPHIC STUDIES USING TRITIUM-LABELED THYMIDINEE

1957 • 824 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 796 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

The biology of the cell cycle

1971 • 730 citations

Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei

1970 • 699 citations

Molecular Mechanisms for Repair of DNA

1975 • 676 citations

The fetal hydantoin syndrome

1975 • 602 citations

Differential giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiography

1974 • 598 citations

Progress in Genetic Toxicology

1978 • 581 citations

Identifying Environmental Chemicals Causing Mutations and Cancer

1979 • 575 citations

Living Blood Cells and their Ultrastructure

1972 • 561 citations

Living Blood Cells and Their Ultrastructure

1974 • 556 citations

Sister Chromatid Exchanges, Indices of Human Chromosome Damage and Repair: Detection by Fluorescence and Induction by Mitomycin C

1974 • 491 citations

Chromosomes and Cancer.

1975 • 437 citations

Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests

1975 • 425 citations

MATERNAL EPILEPSY AND ABNORMALITIES OF THE FETUS AND NEWBORN

1972 • 412 citations

Giemsa technique for the detection of sister chromatid exchanges

1974 • 363 citations

Mechanisms of chromosomal aberration production III. Chemicals and ionizing radiation

1974 • 363 citations

Microtechnique for Culturing Leukocytes from Whole Blood

1963 • 341 citations

Sister chromatid exchanges induced in chinese hamster cells by UV irradiation of different stages of the cell cycle: The necessity for cells to pass through S

1974 • 312 citations

Spontaneous sister chromatid exchanges detected by a BUdR-labelling method

1974 • 309 citations

Zur Frage der Entstehung maligner Tumoren

1914 • 294 citations

Molecular mechanisms involved in the production of cromosomal aberrations II. Utilization of neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle

1980 • 280 citations

DNA synthesis and mitosis in cultures of human peripheral leukocytes

1962 • 266 citations

A quantitative cytochemical investigation of the relationship between cell mass and initiation of DNA synthesis in mouse fibroblasts in vitro

1965 • 251 citations

Quantitative cytochemical studies on interphase growth

1965 • 244 citations

Reproduction of Eukaryotic Cells

1976 • 235 citations

Handbook of mutagenicity test procedures

1978 • 229 citations

Anticonvulsant Drugs and Congenital Abnormalities

1968 • 218 citations

The utilization of bromodeoxyuridine incorporation into DNA for the analysis of cellular kinetics

1976 • 216 citations

The relation between reaction kinetics and mutagenic action of mono-functional alkylating agents in higher eukaryotic systems

1979 • 211 citations

Lymphocyte stimulation

1975 • 210 citations

Radiation-induced chromosome aberrations in nuclear-dockyard workers

1979 • 208 citations

Localization of Sister Chromatid Exchanges in Human Chromosomes

1974 • 205 citations

Mutagen-induced Chromosome Damage in Man

1979 • 205 citations

Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomes

1975 • 204 citations

Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair

1974 • 197 citations

Sister chromatid exchanges induced by light flashes to 5-bromodeoxyuridine- and 5-iododeoxyuridine substituted Chinese hamster chromosomes

1974 • 195 citations

'BACTERURITEST' STRIPS

1976 • 194 citations

Lymphocyte Stimulation

1968 • 180 citations

Induction of sister chromatid exchanges by UV light and its inhibition by caffeine

1973 • 180 citations

Human Radiation Cytogenetics

1968 • 179 citations

Lymphocyte activation. II. discriminating stimulation of lymphocyte subpopulations by phytomitogens and heterologous antilymphocyte sera.

1972 • 178 citations

The fetal trimethadione syndrome

1975 • 178 citations

Cancer: Science and Society.

1979 • 173 citations

Lithium and Pregnancy--I, Report from the Register of Lithium Babies

1973 • 170 citations

Mutagenic, cancerogenic and teratogenic effects of alcohol

1979 • 170 citations

Analysis of human lymphocyte cell cycle time in culture measured by sister chromatid differential staining

1977 • 169 citations

Chromatin Structure and the Cell Cycle

1972 • 166 citations

Caffeine and chromosomes

1978 • 165 citations

Persons at High Risk of Cancer. An Approach to Cancer Etiology and Control

1976 • 164 citations

Differential inhibition of the products of the human alkaline phosphatase loci

1978 • 163 citations

Chromosome aberrations and radiation-induced cell death

1973 • 156 citations

The fate of chromosome aberrations

1973 • 155 citations

Chromosome aberrations and radiation-induced cell death

1973 • 153 citations

Lithium and Pregnancy--III, Lithium Ingestion by Children Breast-Fed by Women on Lithium Treatment

1973 • 153 citations

Proliferation of Human Lymphocytes in Culture

1966 • 152 citations

Molecular mechanisms involved in the production of chromosomal aberrations

1978 • 152 citations

Initial changes of deoxyribonucleoprotein and synthesis of nucleic acid in phytohemagglutinine-stimulated human leucocytes

1965 • 151 citations

Advances in radiation biology

1975 • 149 citations

Advances in cell and molecular biology

1973 • 148 citations

LSD and Genetic Damage

1971 • 144 citations

Transplanted Nuclei and Cell Differentiation

1968 • 140 citations

Epilepsy. The eighth international symposium

1978 • 138 citations

CONGENITAL MALFORMATIONS AMONG INFANTS BORN TO EPILEPTIC WOMEN

1973 • 138 citations

Effect of Bursectomy and Thymectomy on the Responses of Chicken Peripheral Blood Lymphocytes to Phytohaemagglutinin

1968 • 137 citations

Evidence for Transformation of Human B Lymphocytes by PHA

1973 • 131 citations

Factors influencing chromosome aberration yields in the human peripheral leukocyte system

1969 • 126 citations

Analysis of Interphase Chromosome Damage by Means of Premature Chromosome Condensation after X- and Ultraviolet-Irradiation

1974 • 125 citations

THE FREQUENCY OF SISTER CHROMATID EXCHANGES FOLLOWING EXPOSURE TO VARYING DOSES OF H3-THYMIDINE OR X-RAYS

1964 • 116 citations

SPATIAL RELATIONSHIPS IN THE REPLICATION OF CHROMOSOMAL DNA

1965 • 110 citations

The phenomenon of premature chromosome condensation: its relevance to basic and applied research

1974 • 109 citations

Biological Damage from Intranuclear Tritium: DNA Strand Breaks and Their Repair

1972 • 108 citations

Homogeneous sensitivity of human peripheral blood lymphocytes to radiation-induced chromosome damage

1979 • 107 citations

Research Advances in Alcohol and Drug Problems

1981 • 106 citations

Mechanisms of chromosomal aberration production I. Aberration induction by ultraviolet light

1973 • 105 citations

Synthetic activities leading to mitosis

1963 • 104 citations

Chemical Mutagens Environmental Effects on Biological Systems

1970 • 102 citations

Mutationstheorie der Geschwulst-Entstehung

1928 • 102 citations

Sind antiepileptische Medikamente während der Schwangerschaft schädlich?

1964 • 100 citations

CHROMOSOME DUPLICATION AND STRUCTURE AS DETERMINED BY AUTORADIOGRAPHY

1963 • 99 citations

Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence.

1973 • 99 citations

The repair of X-ray-induced chromosome aberrations in stimulated and unstimulated human lymphocytes

1972 • 96 citations

Comparative aspects of the effects of radiation during oogenesis

1971 • 94 citations

Sister chromatid exchanges induced by mitomycin C: a new method of detecting DNA damage at chromosomal level

1975 • 93 citations

Chromosome Pulverization in Human Cells With Micronuclei<xref ref-type="fn" rid="FN2">2</xref>

1968 • 93 citations

Congenital Abnormalities and Anticonvulsant Drugs

1970 • 92 citations

TERATOGENIC EFFECT OF ANTICONVULSANTS

1972 • 92 citations

Evidence derived from sister chromatid exchanges of restricted rejoining of chromatid subunits

1975 • 91 citations

Effects of six carcinogens on SCE frequency and cell kinetics in cultured human lymphocytes

1977 • 91 citations

Activation of deoxyribonucleoprotein in human leucocytes stimulated by phytohemagglutinin

1969 • 91 citations

Chromosome Investigations on Lymphocytes from Irradiated Patients: Effect of Time in Culture

1964 • 88 citations

The role of non-disjunction in aneuploidy in man an overview

1979 • 88 citations

Induction of sister chromatid exchanges in chromosomes of rat kangaroo cells by tritium incorporated into DNA

1972 • 88 citations

Synchronization of mammalian cells in vitro by inhibition of the DNA synthesis

1966 • 87 citations

Premature chromosome condensation

1976 • 87 citations

Lymphocyte chromosome studies in humans exposed to chemical mutagens

1976 • 85 citations

Mutagenicity studies with X-ray-contrast media, analgesics, antipyretics, antirheumatics and some other pharmaceutical drugs in bacterial, Drosophila and mammalian test systems

1979 • 85 citations

The effect of triated thymidine on sister chromatid exchange in a ring chromosome

1969 • 81 citations

SCE in B and T lymphocytes. Possible implications for Bloom's syndrome

1979 • 76 citations

Chromosomal aberrations in peripheral lymphocytes of alcoholics

1980 • 75 citations

Chromatidaustausch und Heterochromatinver�nderungen menschlicher Chromosomen nach BUdR-Markierung

1974 • 71 citations

Activation of deoxyribonucleoprotein in human leucocytes stimulated by phytohemagglutinin

1969 • 70 citations

Photoreactivation of sister chromatid exchanges induced by ultraviolet irradiation

1974 • 70 citations

Cigarette smoke condensates damage DNA in human lymphocytes

1979 • 69 citations

Cell-cycle duration and sister-chromatid exchange frequency in cultured human lymphocytes

1979 • 68 citations

The Teratological Effects of Anticonvulsants and the Effects on Pregnancy and Birth

1973 • 67 citations

Comparisons of Tritiated Thymidine, Tritiated Water, and Colbalt-60 Gamma Rays in Inducing Chromosomal Aberrations

1965 • 66 citations

The replication and organization of DNA in chromosomes

1962 • 66 citations

Absence of Significant Chromosome Damage in Males Occupationally Exposed to Lead

1974 • 66 citations

Survival of Human T and B Lymphocytes after X-irradiation

1976 • 66 citations

The human leukocyte test system. III. Premature chromosome condensation from chemically and x-ray induced micronuclei.

1975 • 64 citations

Radiosensitivity of Human Lymphocytes and Thymocytes

1977 • 64 citations

The human leukocyte test system

1975 • 63 citations

Synthesis and accumulation of nuclear and cytoplasmic proteins during interphase in mouse fibroblasts in vitro

1966 • 63 citations

Sister chromatid exchanges in human leukocyte chromosomes: Spontaneous and induced frequencies in early- and late-proliferating cells in vitro

1979 • 63 citations

Cell cycle analysis in asynchronous cultures using the BUdR-Hoechst technique

1976 • 62 citations

Chromosomenschäden bei beruflicher Bleibelastung

1970 • 62 citations

Die cytogenetische wirkung von blei in menschlichen peripheren lymphocyten in vitro und in vivo

1972 • 61 citations

Time-course of DNA synthesis in human leukocyte cultures

1963 • 61 citations

Variability of the time at which PHA-stimulated lymphocytes initiate DNA synthesis

1973 • 57 citations

Aberrations Induced in Human Leukocyte Chromosomes by <sup>3</sup>H-Labeled Nucleosides

1962 • 55 citations

DNA REPAIR AND MUTAGENESIS IN MAMMALIAN CELLS*^,†

1978 • 55 citations

Mechanisms of chromosomal aberration production II. Aberrations induced by 5-bromodeoxyuridine and visible light

1973 • 55 citations

Ultrastructure and Function of Heterochromatin and Euchromatin

1974 • 55 citations

Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis

1969 • 54 citations

The human leukocyte test system

1974 • 52 citations

The human leukocyte test system

1975 • 52 citations

Heterogenous chromosomal radiosensitivity of phytohaemagglutinin-stimulated human blood lymphocytes in culture

1973 • 51 citations

The effect of X-rays on labelling pattern of M1 and M2 chromosomes in Chinese hamster cells

1973 • 51 citations

The Dose-Effect Relationship of Chromosome Aberrations to α and γ Irradiation in a Population Subjected to an Increased Burden of Natural Radioactivity

1979 • 50 citations

Premature chromosome condensation, structural chromosome aberrations, and micronuclei in early mouse embryos after treatment of paternal postmeiotic germ cells with triethylenemelamine possible mechanisms for chemically induced dominant-lethal mutations

1975 • 49 citations

Chromosomenanalyse bei Verkehrspolizisten mit Erhöhter Bleilast

1972 • 49 citations

EARLY EVENTS IN LYMPHOCYTE TRANSFORMATION BY PHYTOHEMAGGLUTININ

1972 • 48 citations

In vitro response of lymphocytes to phytohemagglutinin (PHA) as studied with antiserum to PHA

1972 • 48 citations

SYNTHETIC CAPACITIES OF CHROMOSOME FRAGMENTS CORRELATED WITH THEIR ABILITY TO MAINTAIN NUCLEOLAR MATERIAL

1962 • 48 citations

Chromosome damage in chinese hamster cells sensitized to near-ultraviolet light by psoralen and angelicin

1977 • 48 citations

Chromosome Aberrations and T-Cell Survival in Human Lymphocytes

1974 • 47 citations

Kinetics of human lymphocyte division and chromosomal radiosensitivity

1979 • 47 citations

Studies on in vitro lymphocyte proliferation in cultures synchronized by the inhibition of DNA synthesis

1970 • 46 citations

Repair of Gamma-ray and Neutron-induced Lesions in Germinating Barley Seeds

1971 • 46 citations

Chromosome and chromatid exchanges in chinese hamster cells

1973 • 45 citations

Human B and T lymphocytes differ in UV-induced repair capacity

1978 • 42 citations

Die Mutationstheorie der Geschwulstentstehung

1963 • 42 citations

Chromosome Aberrations among the Yanomama Indians

1970 • 41 citations

The human leukocyte test system

1975 • 41 citations

The effect of sodium fluoride on DNA synthesis, mitotic indices and chromosomal aberrations in human leukocytes treated with trenimon in vitro

1976 • 40 citations

Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin

1976 • 40 citations

The Influence of Temperature at Irradiationin Vitroon the Yield of Chromosomal Aberrations in Peripheral Blood Lymphocytes

1969 • 40 citations

RNA SYNTHESIS IN HELA CELLS

1970 • 38 citations

Chromosomal Damage by Alcohol In Vitro and In Vivo

1977 • 38 citations

Effect of lead acetate of human leukocyte chromosomes in vitro

1974 • 38 citations

Chromosomal breakage in leukocytes of South American Indians

1973 • 37 citations

The human leukocyte test system

1975 • 37 citations

Cell-cycle and Radiosensitivity of the Chromosomes of Human Leukocytes

1965 • 37 citations

The nucleoli of cultured human lymphocytes

1976 • 36 citations

Protein synthesis and ribosome activation during the early stages of phytohemagglutinin lymphocyte stimulation

1975 • 36 citations

Increase of UV-induced DNA repair synthesis during blast transformation of human lymphocytes

1979 • 35 citations

Mitogenic Factors Produced by Lymphocyte Activation: Effect on T- and B-Cells

1972 • 35 citations

Premature chromosome condensation in the bone marrow of Chinese hamsters after application of bleomycin in vivo

1975 • 35 citations

Analyse des changes de chromatides dans les cellules somatiques humaines: Traitement au BUDR (5 bromodoxyuridine) et fluorescence bicolore par l'acridine orange

1974 • 34 citations

Trenimon: Biochemical, physiological and genetic effects on cells and organisms

1979 • 33 citations

CHROMOSOME PULVERIZATION IN MICRONUCLEI INDUCED BY TRITIATED THYMIDINE

1972 • 32 citations

Fate of Chromatin of Interphase Nuclei Subjected to “Prophasing” in Virus-Fused Cells2

1972 • 30 citations

The human leukocyte test system

1974 • 29 citations

SAMPLING TIME AND THE COMPLEXITY OF THE HUMAN LEUKOCYTE CULTURE SYSTEM.

1968 • 29 citations

Chemical Mutagens: Principles and Methods for their Detection

1974 • 29 citations

Proliferation of PHA-stimulated lymphocytes measured by combined autoradiography and sister chromatid differential staining

1979 • 28 citations

The human leukocyte test system

1976 • 27 citations

Banbury Report. 1. Assessing Chemical Mutagens: The Risk to Humans

1981 • 26 citations

Spontaneous chromosomal aberration levels in human peripheral lymphocytes

1978 • 26 citations

Sister chromatid exchanges in down syndromes and normal human beings

1977 • 26 citations

Human lymphocyte cell cycle: Studies with the use of BrUdR

1979 • 25 citations

The frequency and distribution of isolabelling in Chinese hamster chromosomes after exposure to X-rays

1974 • 25 citations

CHROMOSOME PULVERIZATION IN CHINESE HAMSTER MULTINUCLEATE CELLS INDUCED BY BLEOMYCIN AND CYTOCHALASIN B

1973 • 24 citations

The Kinetics of Chromatid Aberrations Induced in Chinese Hamster Cells by Tritium-Labeled Thymidine

1966 • 23 citations

Early in vitro division of PHA stimulated cord blood lymphocytes: implications for study of chromosome breakage.

1976 • 23 citations

Virus-Induced Chromosomal Alterations in Mammals and Man

1970 • 23 citations

Das lymphatische Zellsystem: Struktur, allgemeine Physiologie und allgemeine Pathophysiologie

1976 • 22 citations

H<sup>3</sup>-Uridine Autoradiography of Human Chromosomes

1966 • 20 citations

Quantitative studies on RNA accumulation in human PHA-stimulated lymphocytes during blast transformation

1973 • 20 citations

Differential chromosomal radiosensitivity within the first G1-phase of the cell cycle of early-dividing human leukocytes in vitro after stimulation with PHA

1977 • 20 citations

Occurrence of 1st division metaphases in human lymphocyte cultures

1978 • 20 citations

Is Lithium Mutagenic in Man?

2008 • 20 citations

Lack of synergistic effect between X-ray and UV irradiation on the frequency of chromosome aberrations in PHA-stimulated human lymphocytes in the G1 stage

1976 • 19 citations

Chromosomal Damage in Chronical Users of Cannabis In Vivo Investigation with Two-day Leukocyte Cultures

1974 • 19 citations

Lymphozyt und klinische Immunologie

1975 • 19 citations

Trenimon-induced SCEs and structural chromosomal aberrations in early- and late-dividing lymphocytes

1980 • 18 citations

Nuclear and cytoplasmic nucleic acid content and cytoplasmic protein synthesis during interphase in mouse fibroblasts in vitro

1966 • 18 citations

Effects of inhibitors of DNA, RNA and protein synthesis on frequencies and types of premature chromosome condensation from X-ray induced micronuclei

1976 • 18 citations

In vitro response of lymphocytes to phytohemagglutinin (PHA) as studied with antiserum to PHA

1975 • 18 citations

Gene Expression, Volume 2: Eucaryotic Chromosomes

1974 • 17 citations

Sister chromatid exchanges in isolabeling

1974 • 17 citations

The in vivo and in vitro effects of lithium on human chromosomes and cell replication

1976 • 17 citations

The human leukocyte test system

1975 • 17 citations

Differences in Chromatin proteins of resting and growing human lymphocytes

1976 • 17 citations

Chromosomal breaks in T and B lymphocytes in Fanconi's anemia

1976 • 16 citations

The Chromosome Cycle

1970 • 16 citations

History of Research on Chemical Mutagenesis

1973 • 16 citations

Chromosome pulverization and RNA synthesis.

1971 • 15 citations

Viruses and Chromosomes

1974 • 14 citations

Chromatidaustausch und Heterochromatinvernderungen menschlicher Chromosomen nach BUdR-Markierung: Nachweis mit Benzimidazolfluorochrom und Giemsafarbstoff

1974 • 14 citations

Premature chromosome condensation in a case of Fanconi's anemia

1975 • 14 citations

Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro

1980 • 12 citations

Premature Chromosome Condensation Following X Irradiation of Mammalian Cells: Expression Time and Dose-Response

1979 • 12 citations

The Response of Human Peripheral Lymphocytes to Various Mitogenic Agents in vitro

1968 • 11 citations

Premature chromosome condensation in the bone marrow of Chinese hamsters after whole body irradiation with Co60 γ raysin vivo

1975 • 11 citations

Human Peripheral Blood Leukocyte Cultures

1974 • 11 citations

No elevation of exchange type aberrations in lymphocytes of children with alcohol embryopathy

1978 • 10 citations

Chromosome Variations in Human Evolution.

1976 • 10 citations

Aberrations of holokinetic chromosomes and associated lethality after x-irradiation of meiotic stages in Tetranychus urticae Koch (acari, tetranychidae)

1979 • 10 citations

The human leukocyte test system

1976 • 10 citations

Studies on the influence of liquid holding in Con-A stimulated human peripheral blood lymphocytes on mitosis and X-ray induced chromosome aberrations

1980 • 10 citations

Fate of fragments and properties of translocations of holokinetic chromosomes after X-irradiation of mature sperm of Tetranychus urticae koch (acari, tetranychidae)

1979 • 9 citations

Demonstration of a very short post-mitotic G1 period in proliferating PHA-stimulated lymphocytes

1973 • 8 citations

Differential chromosomal sensitivities of aneusomic cell clones to UV light

1974 • 7 citations

Kinetics of lymphocyte division in blood cultures studied with the BrdU-giemsa technique

1976 • 7 citations

DNA synthesis and distribution of first and second divisions in 72-h-cultures of human leukocytes

1972 • 7 citations

The human leukocyte test system

1976 • 7 citations

Premature chromosome condensation in irradiated man

1976 • 6 citations

Epilepsy: Problems of Marriage, Pregnancy, Genetic Counseling

1983 • 5 citations

CONGENITAL MALFORMATIONS AND ANTICONVULSANT DRUGS

1973 • 5 citations

The Chromosome Cycle

1969 • 4 citations

Teratologische Wirkungen von Antiepileptika

2015 • 4 citations

Zum Problem pr�nataler Sch�digungen bei antiepileptischer Therapie

2015 • 3 citations

DNA Repair in Human Cells: Enzymes and Mutants

1978 • 3 citations

Enzymes Involved in the Repair of Damaged DNA

1978 • 2 citations