Prophylaxis and treatment of leukemia in the central nervous system and other sanctuaries.

The central nervous system in childhood leukemia.II. Subacute leukoencephalopathy

1975 • 484 citations

The increasing incidence of central nervous system leukemia in children.(Children's cancer study group a)

1970 • 310 citations

Neurologic sequelae of methotrexate and ionizing radiation: a new classification.

1981 • 271 citations

A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemia

1972 • 242 citations

The effects of prophylactic treatment of the central nervous system on the intellectual functioning of children with acute lymphocytic leukemia

1981 • 232 citations

Comparison of Intermediate-Dose Methotrexate with Cranial Irradiation for the Post-Induction Treatment of Acute Lymphocytic Leukemia in Children

1983 • 177 citations

Childhood acute lymphocytic leukemia. Study VIII

1978 • 173 citations

Treatment of meningeal neoplasms.

1977 • 160 citations

"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms

1978 • 149 citations

Equivalence of intrathecal chemotherapy and radiotherapy as central nervous system prophylaxis in children with acute lymphatic leukemia: a pediatric oncology group study

1982 • 135 citations

Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen.

1983 • 118 citations

Factors associated with IQ scores in long-term survivors of childhood acute lymphoblastic leukemia

1984 • 115 citations

Chronic neurologic disturbance in childhood leukemia

1976 • 115 citations

Extramedullary involvement of the testes in childhood leukemia

1975 • 109 citations

Clinical Investigations in the Treatment of Meningeal Leukemia: Radiation Therapy Regimens vs. Conventional Intrathecal Methotrexate

1969 • 108 citations

Leydig-Cell Function in Children after Direct Testicular Irradiation for Acute Lymphoblastic Leukemia

1983 • 104 citations

Testicular relapse in childhood acute lymphoblastic leukemia: Association with pretreatment patient characteristics and treatment. A report for childrens cancer study group

1980 • 102 citations

Remission induction of meningeal leukemia with high-dose intravenous methotrexate.

1985 • 101 citations

The effects of cancer therapy on the nervous system

1978 • 98 citations

Cessation of Therapy during Complete Remission of Childhood Acute Lymphocytic Leukemia

1974 • 86 citations

Intracranial calcifications in childhood leukemia

1977 • 86 citations

Pathology of leukemia in the brain and meninges: postmortem studies of patients with acute leukemia and of mice given inoculations of L1210 leukemia.

1965 • 80 citations

Sanctuary therapy: a randomized trial of 724 children with previously untreated acute lymphoblastic leukemia: A Report from Children's Cancer Study Group.

1982 • 79 citations

Abnormal computed tomography brain scans in children with acute lymphoblastic leukemia: serial long-term follow-up.

1985 • 72 citations

Testicular relapse in childhood acute lymphocytic leukemia during bone marrow remission

1976 • 70 citations

Serial cranial computed-tomography scans in children with leukemia given two different forms of central nervous system therapy.

1983 • 69 citations

Pathogenesis of central nervous system infiltration in acute leukemia.

1977 • 69 citations

COMPARISON OF THREE METHODS OF CENTRAL-NERVOUS-SYSTEM PROPHYLAXIS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKÆMIA

1980 • 65 citations

Combination intrathecal therapy for meningeal leukemia: two versus three drugs

1977 • 62 citations

EFFECT OF ISOLATED CENTRAL NERVOUS SYSTEM LEUKAEMIA ON BONE MARROW REMISSION AND SURVIVAL IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA

1981 • 57 citations

Central Nervous System Involvement by Leukemia in Children. II. Therapy with Intrathecal Methotrexate

1965 • 55 citations

Isolated testicular relapse in boys with acute lymphoblastic leukaemia: treatment and outcome.

1982 • 53 citations

Relapse rates following cessation of chemotherapy during complete remission of acute lymphocytic leukemia

1979 • 51 citations

CT abnormalities and altered methotrexate clearance in children with CNS leukemia

1984 • 50 citations

Methotrexate levels in the interstitial space and seminiferous tubule of rat testis.

1982 • 49 citations

CNS prophylaxis in acute lymphoblastic leukemia. Comparison of two methods a southwest oncology group study

1982 • 49 citations

Treatment of meningeal relapse in childhood acute lymphoblastic leukemia. I. Results of craniospinal irradiation.

1984 • 48 citations

Biochemical Markers of Central Nervous System Tumors Measured in Cerebrospinal Fluid and Their Potential Use in Diagnosis and Patient Management: A Review<xref ref-type="fn" rid="FN2">2</xref>

1979 • 45 citations

Studies on the Use of "Prophylactic" Intrathecal Amethopterin in Childhood Leukemia

1970 • 43 citations

A clinical perspective on cell markers in acute lymphocytic leukemia.

1981 • 42 citations

Superiority of conventional intrathecal methotrexate therapy with maintenance over intensive intrathecal methotrexate therapy, unmaintained, or radiotherapy (2000-2500 rads tumor dose) in treatment for meningeal leukemia

1975 • 42 citations

Remission Maintenance Therapy for Meningeal Leukemia: Intrathecal Methotrexate vs. Intravenous bis-Nitrosourea

1971 • 41 citations

Long-term control of central nervous system leukaemia.

1977 • 40 citations

Poor prognosis of children with acute lymphocytic leukemia and increased B cell markers

1976 • 37 citations

TESTICULAR INFILTRATION IN ACUTE LYMPHOBLASTIC LEUKAEMIA

1983 • 32 citations

The impact of isolated central nervous system relapse following initial complete remission in childhood acute lymphocytic leukemia

1980 • 32 citations

Nuclear terminal deoxynucleotidyl transferase in leukaemic infiltrates of testicular tissue

1982 • 31 citations

Isolated testicular relapse in acute lymphoblastic leukaemia of childhood: Report on behalf of the Medical Research Council's working party on leukaemia in childhood

1983 • 28 citations

Intensive Therapy and Prognostic Factors in Acute Lymphoblastic Leukemia of Childhood: CCG 141

1981 • 22 citations

IMFRA (Intermittent Intrathecal Methotrexate and Fractional Radiation) plus chemotherapy in childhood leukemia

1976 • 21 citations

Treatment of overt CNS leukemia.

1979 • 20 citations

Intrathecal Methotrexate Versus Central Nervous System Leukemia

1984 • 18 citations

RESERVOIRS FOR INTRAVENTRICULAR CHEMOTHERAPY

1973 • 18 citations

Remission Maintenance Therapy for Meningeal Leukaemia: Intrathecal Methotrexate and Dexamethasone versus Intrathecal Craniospinal Irradiation with a Radiocolloid

1976 • 18 citations

Therapy of acute lymphocytic leukemia in childhood with intermediate dose methotrexate and CNS irradiation

1983 • 17 citations

Treatment of Overt CNS Leukaemia

1983 • 14 citations

Radiation in the treatment of meningeal leukemia.

1979 • 11 citations

Intermittent Intrathecal Methotrexate and Fractional Radiation (M-Imfra) plus Chemotherapy in Childhood Leukemia

1978 • 6 citations