Functional interactions within 23S rRNA involving the peptidyltransferase center

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

The Molecular Basis of Antibiotic Action

1981 • 1,237 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

Construction and fine mapping of recombinant plasmids containing the rrnB ribosomal RNA operon of E. coli

1981 • 476 citations

Inhibitors of protein synthesis

1974 • 411 citations

A Compilation of large subunit RNA sequences presented in a structural format

1988 • 377 citations

Sequence of the intron and flanking exons of the mitochondrial 21S rRNA gene of yeast strains having different alleles at the ω and rib-1 loci

1980 • 373 citations

Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA

1987 • 337 citations

[46] Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli

1988 • 187 citations

Altered ribosomal RNA genes in mitochondria from mammalian cells with chloramphenicol resistance

1981 • 154 citations

Chloramphenicol-erythromycin resistance mutations in a 23S rRNA gene of Escherichia coli

1985 • 149 citations

Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes

1982 • 148 citations

Feedback regulation of rRNA and tRNA synthesis and accumulation of free ribosomes after conditional expression of rRNA genes.

1985 • 148 citations

Sites of interaction of the CCA end of peptidyl-tRNA with 23S rRNA.

1991 • 144 citations

Characterization of the binding sites of protein L11 and the L10.(L12)4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli

1990 • 127 citations

The importance of highly conserved nucleotides in the binding region of chloramphenicol at the peptidyl transfer centre of Escherichia coli 23S ribosomal RNA.

1988 • 118 citations

Identification of two erythromycin resistance mutations in the mitochondrial gene coding for the large ribosomal RNA in yeast

1982 • 118 citations

Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA.

1981 • 106 citations

Defining the Structural Requirements for a Helix in 23 S Ribosomal RNA that Confers Erythromycin Resistance

1989 • 87 citations

A plasmid-coded and site-directed mutation in Escherichia coli 23S RNA that confers resistance to erythromycin: implications for the mechanism of action of erythromycin

1987 • 83 citations

Mutants of Escherichia coli lacking ribosomal protein L11.

1980 • 82 citations

Erythromycin and spiramycin resistance mutations of yeast mitochondria: nature of therib2locus in the large ribosomal RNA gene

1984 • 80 citations

Different nucleotide changes in the large rRNA gene of the mitochondrial DNA confer chloramphenicol resistance on two human cell lines

1981 • 79 citations

Chloramphenicol resistance mutations in the single 23S rRNA gene of the archaeon Halobacterium halobium

1991 • 72 citations

23S Ribosomal RNA mutations in halobacteria conferring resistance to the anti-80S ribosome targeted antibiotic anisomycin

1987 • 63 citations

Mapping of chloroplast mutations conferring resistance to antibiotics in Chlamydomonas: Evidence for a novel site of streptomycin resistance in the small subunit rRNA

1988 • 62 citations

Evidence for functional interaction between domains II and V of 23S ribosomal RNA from an erythromycin-resistant mutant.

1985 • 56 citations

Point mutations in the 23 S rRNA genes of four lincomycin resistant Nicotiana plumbaginifolia mutants could provide new selectable markers for chloroplast transformation

1988 • 49 citations

Sequence analysis of mitochondrial DNA in a mouse cell line resistant to chloramphenicol and oligomycin.

1983 • 44 citations

The three-dimensional folding of ribosomal RNA; localization of a series of intra-RNA cross-links in 23S RNA induced by treatment ofEscherichia coli50S ribosomal subunits withbis-(2-chloroethyl)-methylamine

1991 • 40 citations

A mutation in the large subunit ribosomal RNA gene of Tetrahymena confers anisomycin resistance and cold sensitivity.

1991 • 23 citations

Sequence Analysis of Mitochondrial DNA in a Mouse Cell Line Resistant to Chloramphenicol and Oligomycin

1983 • 17 citations

Deleted Work

1955 • 0 citations